{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:42:39Z","timestamp":1784698959718,"version":"3.55.0"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016132","name":"Gouvernement Wallon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016132","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the use and osseointegration of dental implants in combination with 3D\u2010printed hydroxyapatite (3DHA) blocks featuring gyroid porosity for large mandibular bone augmentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Mandibular lateral bone augmentation with gyroid\u20103DHA blocks was performed bilaterally on four female G\u00f6ttingen minipigs. After 8 or 12\u2009weeks of healing, a dental implant was placed into each 3DHA block. Following an additional 12\u2010week healing period, the augmented sites (including 3DHA blocks and dental implants) were harvested for histological and histomorphometric analysis, assessing new bone formation, 3DHA integration, total bone gain, and bone\u2010to\u2010implant contact (BIC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Gyroid\u20103DHA blocks were easily fixated with screws. Dental implants were placed through the 3DHA blocks with a standard drilling procedure, and good primary stability was achieved. 3DHA blocks demonstrated good osseointegration with 39.17% of new bone and a significant bone gain of 4.73\u2009mm on average. Dental implants showed comparable BIC within the 3DHA and into the native bone (42.79% vs. 34.17%). No significant difference was found between the healing periods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is the first study to evaluate a 3D\u2010printed bone substitute in combination with a dental implant in an animal study. Gyroid\u20103DHA blocks and dental implants demonstrated good osseointegration, and the bone augmentation was significant, making it a promising material for large and complex alveolar ridge augmentations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.70056","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:30:32Z","timestamp":1760193032000},"page":"101-113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dental Implant Osseointegration Following Mandibular Augmentation Using\n                    <scp>3D<\/scp>\n                    Printed Hydroxyapatite Blocks. An\u00a0Experimental In\u00a0Vivo Study"],"prefix":"10.1111","volume":"37","author":[{"given":"Simon","family":"Systermans","sequence":"first","affiliation":[{"name":"Department of Plastic and Maxillofacial Surgery CHU Li\u00e8ge  Li\u00e8ge Belgium"},{"name":"Faculty of Medicine University of Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Ronsmans","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Li\u00e8ge  Li\u00e8ge Belgium"},{"name":"Department of Plastic, Esthetic and Reconstructive Surgery CHR Citadelle Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9gory","family":"Nolens","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Namur  Namur Belgium"},{"name":"Cerhum SA  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joeri","family":"Meyns","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery ZOL Genk  Genk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Gilon","sequence":"additional","affiliation":[{"name":"Department of Plastic and Maxillofacial Surgery CHU Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0834-8859","authenticated-orcid":false,"given":"Elisabeth","family":"Cobraiville","sequence":"additional","affiliation":[{"name":"Cerhum SA  Li\u00e8ge Belgium"},{"name":"GIGA\u2010In Silico Medicine, Biomechanics Research Unit University of Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JSAMD.2020.01.007"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13649"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.IJOM.2018.08.014"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100501.2011.02385.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/TEN.TEA.2010.0148\/FORMAT\/EPUB"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748\u20106041\/6\/1\/015007"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201017204\u20105"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9111538"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.08.041"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12394"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.11607\/JOMI.8265"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.2097"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ACTBIO.2020.03.016"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278\u20102391(98)90654\u20101"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/CID.13260"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678\u2010775720150597"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma16114117"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2015.10.008"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb13040187"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278\u20102391(88)90143\u20107"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1308\/Rcsfdj.2020.93"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13082408"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.4137\/btri.s36138"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12010006"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2018.12.001"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40824\u2010021\u201000245\u20103"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CERAMINT.2022.05.162"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5862586"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma17112533"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2023.0033"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2022.104323"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/941265"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/JBM.A.32381"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00784\u2010020\u201003206\u20107"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma15072621"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2017.04.009"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0264475"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.7171"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0901\u20105027(05)80131\u20106"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/PRD.12413"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40729\u2010024\u201000541\u20102"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2024.02.026"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/JBM.1222"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12471"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202105002"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2022.0012"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/FBIOE.2021.798393\/BIBTEX"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13102805"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2017.05.007"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13005"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0011\u20108532(22)02094\u20108"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbab077"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1098\/RSIF.2008.0425.FOCUS"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.IJOM.2011.01.007"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10351"}],"container-title":["Clinical Oral Implants Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.70056","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/clr.70056","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.70056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T15:16:52Z","timestamp":1770304612000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/clr.70056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,11]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/clr.70056"],"URL":"https:\/\/doi.org\/10.1111\/clr.70056","archive":["Portico"],"relation":{},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,11]]},"assertion":[{"value":"2025-05-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}