{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T07:46:24Z","timestamp":1770882384807,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100030982","name":"Straumann Group","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030982","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare microbiological and immunological parameters of two sandblasted, large\u2010grit, acid\u2010etched implant surfaces during the first 8\u2009weeks of healing following implant placement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A dual\u2010center, split\u2010mouth, randomized controlled clinical trial was conducted on patients receiving one test (modified hydrophilic surface) and one control (conventional surface) implant in different quadrants. Peri\u2010implant crevicular fluid samples were collected at implant placement and at 1, 2, 4, and 8\u2009weeks to assess biomarkers of inflammation (Interleukin [IL]\u20101\u03b2, IL\u20106, Tumor Necrosis Factor\u2010\u03b1, IL\u20102), biomarkers of anti\u2010inflammation (IL\u20104, IL\u201010), and biomarkers of bone metabolism (osteocalcin, osteopontin [OPN], and vascular endothelial growth factor\u2010\u03b1 [VEGF\u2010\u03b1]). Additionally, submucosal samples were obtained at implant placement and at 1, 2, and 4\u2009weeks and analyzed using quantitative polymerase chain reaction (qPCR) and 16S rRNA sequencing. Biomarkers and qPCR data were analyzed with a general linear model using log10\u2010transformed values. Microbiome data were analyzed via Wilcoxon tests and PERMANOVA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty patients were included in the 8\u2010week analysis. VEGF\u2010\u03b1 levels were significantly higher at 1\u2009week for the conventional surface (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018). OPN and IL\u201010 significantly increased from baseline to 4\u2009weeks in both groups.\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                      <\/jats:styled-content>\n                      and\n                      <jats:italic>Fusobacterium species<\/jats:italic>\n                      were the most prevalent bacteria; however, no significant differences were found between the surfaces in bacterial load analysis by qPCR. Additionally, no significant differences were observed between groups for microbiome diversity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>No differences were detected between the conventional and the modified hydrophilic surfaces in the immunological and microbiological parameters assessed during early implant healing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.70058","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T15:04:52Z","timestamp":1761404692000},"page":"126-140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Early Microbiological and Immunological Parameters in Sandblasted, Large\u2010Grit Acid\u2010Etched Implant Surfaces: A Split Mouth Randomized Clinical 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