{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:16:15Z","timestamp":1783350975043,"version":"3.54.6"},"reference-count":58,"publisher":"Wiley","issue":"S30","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify a core outcome set (COS) to standardize outcome measures for studies on the rehabilitation of the edentulous maxilla in implant dentistry. This work was conducted in preparation for the 1st Global Consensus for Clinical Guidelines (GCCG) for the Rehabilitation of the Edentulous Maxilla.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>The COS was developed using a standardized and validated methodology, following the Core Outcome Measures in Effectiveness Trials (COMET) initiative. Outcomes were first identified through eight systematic reviews covering surgical and prosthetic aspects of edentulous maxilla rehabilitation. This preliminary list was expanded by input from clinical and cross\u2010disciplinary experts as well as patient surveys to capture additional relevant outcomes that were not represented in the literature. A 3\u2010round Delphi survey was conducted. The first round was conducted prior to the meeting and the second and third round took place during the in\u2010person consensus meeting.\u00a0In the first round, participants could propose new outcomes and rated each item using a 9\u2010point Likert scale, from 1 (not important) to 9 (critical), with scores of 7\u20139 denoting critical importance, 4\u20136 importance, and 1\u20133 low importance for decision making. In the second round, participants re\u2010scored a revised outcome list incorporating written suggestions and consolidated overlapping items from the first round. Outcomes rated 7\u20139 by at least 75% of participants in the second round constituted the final COS selection. In the third round, these selected outcomes were evaluated for their relevance across the different stages of the GCCG workflow: patient selection, diagnostic tools, treatment planning, treatment procedure, management of complications during the treatment procedure, maintenance, and management of complications during maintenance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 105 experts invited, response rates for the three Delphi rounds were 87.6%, 95.2%, and 92.4%, respectively. An initial list of 119 outcomes was generated from systematic reviews and surveys and subsequently refined after the first round based on participant feedback. In the second round, 34 outcomes were rated as critical and included in the final COS. These comprised 10 patient\u2010reported outcomes (PROs): aesthetic satisfaction; chewing function\/comfort\/discomfort; complications during treatment\/maintenance; ease of cleaning\/oral hygiene efficacy; pain; patient overall satisfaction with treatment; patient\u2010reported complaints; prosthesis retention\/stability; quality of life; speech\/phonetics\/pronunciation function, 22 objective clinician\u2010reported outcomes (ClinROs): biological complications; history of patient compliance; implant failure; implant primary stability; implant success; implant survival; mechanical\/technical complications; peri\u2010implant health (implant level); peri\u2010implant health (patient level); peri\u2010implant mucositis; peri\u2010implant suppuration; peri\u2010implantitis; plaque index\/oral hygiene; postoperative complications; presence of keratinized mucosa; prosthesis failure; prosthesis success; prosthetic complications; radiographic marginal bone level; radiographic marginal bone loss; surgical\/intraoperative complications; width of keratinized mucosa and two subjective ClinROs (clinician's treatment success; prosthodontic maintenance events\/complications). Additional outcomes proposed during the second round were excluded since they represented general comments, process indicators, or alternative wording of outcomes already considered. In the third round, 21 COS outcomes were deemed relevant to the maintenance and\/or post\u2010treatment complication management phases, 3 were deemed relevant before treatment, and another 3 were deemed relevant only during treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The proposed COS for studies on the rehabilitation of the edentulous maxilla in implant dentistry was developed using the COMET methodology. Although patients' perspectives were incorporated during the preliminary survey phase, they did not participate directly in the Delphi, highlighting an opportunity for future research to further enhance patient involvement in COS development. The widespread implementation of this COS is expected to improve the consistency of outcome reporting and facilitate comparisons of the effectiveness of current and emerging interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.70075","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:22:24Z","timestamp":1772958144000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["1st Global Consensus for Clinical Guidelines: Identifying a Core Outcome Set for Implant Dentistry in Edentulous Maxilla Rehabilitation"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1436-0085","authenticated-orcid":false,"given":"Giulia","family":"Brunello","sequence":"first","affiliation":[{"name":"Department of Oral Surgery University Hospital of D\u00fcsseldorf  D\u00fcsseldorf Germany"},{"name":"Department of Orthodontics and Dentofacial Orthopaedics Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1290-9994","authenticated-orcid":false,"given":"Guo\u2010Hao","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Orofacial Sciences University of California San Francisco School of Dentistry  San Francisco California USA"},{"name":"Department of Periodontics &amp; Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina","family":"Kopp","sequence":"additional","affiliation":[{"name":"AWMF\u2010Institut f\u00fcr Medizinisches Wissensmanagement Philipps\u2010Universit\u00e4t Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3546-3526","authenticated-orcid":false,"given":"Alonso","family":"Carrasco\u2010Labra","sequence":"additional","affiliation":[{"name":"Department of Preventive and Restorative Sciences, School of Dental Medicine, Center for Integrative Global Oral Health University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald E.","family":"Jung","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry, Center of Dental Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4238-1799","authenticated-orcid":false,"given":"Hom\u2010Lay","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Periodontics &amp; Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Implantology and Oral Medicine Goethe University  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5832-7327","authenticated-orcid":false,"given":"Franz J.","family":"Strauss","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry, Center of Dental Medicine University of Zurich  Zurich Switzerland"},{"name":"Universidad Autonoma de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14065"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40729\u2010023\u201000489\u20109"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_1181_19"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102340"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.70018"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.21243"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.21022"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102020\u2010045105"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12162"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8081123"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2019.03.011"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.70063"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2024.105008"},{"key":"e_1_2_12_15_1","unstructured":"FDA\u2010NIH Biomarker Working Group.2016.\u201cBEST (Biomarkers Endpoints and Other Tools) Resource [Internet].\u201d"},{"key":"e_1_2_12_16_1","unstructured":"Fetters L. andJ.Tilson.2018.\u201cEvidence Based Physical Therapy: FA Davis.\u201d"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.70079"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.70020"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13526"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168403"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.09.012"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13823"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13342"},{"key":"e_1_2_12_24_1","unstructured":"Khodyakov D. S.Grant J.Kroger andM.Bauman.2023.\u201cRAND Methodological Guidance for Conducting and Critically Appraising Delphi Panels: Rand.\u201d"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.6869"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002447"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16324"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2011.01842.x"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.70023"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14446"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.70027"},{"key":"e_1_2_12_32_1","volume-title":"The GRADE Book version 1.0","author":"McCaul M.","year":"2025"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13931"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0294193"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.70081"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14451"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14461"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2016.11.005"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063\u2010016\u20101555\u20102"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14454"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.195"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14457"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.70060"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14080"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.70016"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.70084"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.70069"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.70015"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14468"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.14182"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.2023.5.e"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14074"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13061"},{"key":"e_1_2_12_54_1","unstructured":"U.S. Food and Drug Administration F.2021.\u201cGuidance for Industry: Patient\u2010Reported Outcome Measures: Use in Medical Product Development to Support Labeling Claims.\u201d"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063\u2010017\u20101978\u20104"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745\u20106215\u201013\u2010132"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13286"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2019.06.016"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2025.01.011"}],"container-title":["Clinical Oral Implants Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.70075","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/clr.70075","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.70075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T03:55:56Z","timestamp":1773719756000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/clr.70075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":58,"journal-issue":{"issue":"S30","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/clr.70075"],"URL":"https:\/\/doi.org\/10.1111\/clr.70075","archive":["Portico"],"relation":{},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-09-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}