{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T05:00:26Z","timestamp":1793250026819,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"S30","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007619","name":"Osteology Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016070","name":"ITI Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Rehabilitation of the edentulous maxilla poses major clinical and patient\u2010centered challenges. While implant survival and marginal bone level changes dominate the literature, patient\u2010reported outcomes (PROs) such as aesthetic satisfaction, comfort, and quality of life remain underrepresented. The Global Consensus for Clinical Guidelines (GCCG) aimed to develop an international, consensus\u2010based guideline for maxillary rehabilitation that integrates PROs and clinician\u2010reported outcomes (ClinROs) within a structured treatment workflow and to identify future research priorities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This S2k\u2010level guideline was developed through a multi\u2010phase process involving clinical experts, a methodologist, patients, and interdisciplinary contributors. Evidence synthesis included eight systematic reviews and six structured surveys. A Core Outcome Set (COS) of 34 critically important outcomes (10 PROs, 22 objective and 2 subjective ClinROs) was established via a three\u2010round Delphi process with 105 experts. Consensus recommendations were generated and voted upon by 105 delegates from 26 countries using nominal group technique and anonymous plenary voting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The guideline defines 36 consensus\u2010based recommendations mapped to 34 COS outcomes, covering all phases of care, patient selection, diagnostics, surgical and prosthetic treatment, complication management, and maintenance. It emphasizes shared decision\u2010making, prosthetically driven planning, immediate protocols when feasible, and risk\u2010based maintenance to prevent surgical, biological, and technical complications. A clinical workflow checklist and decision trees support practical implementation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is the first global guideline for edentulous maxilla rehabilitation integrating a COS across all treatment phases, fostering evidence\u2010based, outcome\u2010driven, and patient\u2010centered implant care worldwide.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.70084","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:22:24Z","timestamp":1772958144000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["First Global Consensus for Clinical Guidelines: Structured Recommendations (S2k\u2010Level Guideline Framework) for the Rehabilitation of the Edentulous Maxilla Based on Core Outcome Sets"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5873-9903","authenticated-orcid":false,"given":"Frank","family":"Schwarz","sequence":"first","affiliation":[{"name":"Department of Oral Surgery, Implantology and Oral Medicine Goethe University  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald E.","family":"Jung","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry, Center for Dental Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina","family":"Kopp","sequence":"additional","affiliation":[{"name":"AWMF\u2010Institute for Medical Knowledge Management, Philipps\u2010University Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5755-8265","authenticated-orcid":false,"given":"Lisa","family":"Heitz\u2010Mayfield","sequence":"additional","affiliation":[{"name":"The University of Western Australia, International Research Collaborative, Oral Health and Equity, School of Human Anatomy and Biology  Crawley West Australia Australia"},{"name":"The University of Sydney, School of Dentistry, Faculty of Medicine and Health  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4238-1799","authenticated-orcid":false,"given":"Hom\u2010Lay","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Periodontics &amp; Oral Medicine, University of Michigan School of Dentistry  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The participants of the First Global Consensus Conference Group for Implant Dentistry (GCCG)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"AWMF G. A. O. T. S. M. S. and Commission S. G.\u201cAWMF Guidance Manual and Rules for Guideline Development.\u201dhttp:\/\/www.awmf.org\/leitlinien\/awmf\u2010regelwerk.html."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.70075"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.70018"},{"key":"e_1_2_11_5_1","volume-title":"The SAC Classification in Implant Dentistry 2nd Edition","author":"Dawson A.","year":"2022"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.70063"},{"key":"e_1_2_11_7_1","unstructured":"Editors I. C. o. M. J.2012.\u201cICMJE Form for Disclosure of Potential Conflicts of Interest.\u201dhttps:\/\/www.icmje.org\/disclosure\u2010of\u2010interest\/."},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/498305"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.70079"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.70020"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13639"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.70023"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14446"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.70027"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta2030"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.70081"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14451"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14461"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14454"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14457"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.70060"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.70016"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14\u20101885"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.11607\/ijp.consensusreport"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.70069"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.70015"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14468"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13808"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063\u2010017\u20101978\u20104"}],"container-title":["Clinical Oral Implants Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.70084","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/clr.70084","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.70084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T03:54:59Z","timestamp":1773719699000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/clr.70084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":28,"journal-issue":{"issue":"S30","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/clr.70084"],"URL":"https:\/\/doi.org\/10.1111\/clr.70084","archive":["Portico"],"relation":{},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}