{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:53:20Z","timestamp":1781524400948,"version":"3.54.1"},"reference-count":63,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007619","name":"Osteology Foundation","doi-asserted-by":"publisher","award":["18\u2010117"],"award-info":[{"award-number":["18\u2010117"]}],"id":[{"id":"10.13039\/501100007619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate whether adding a connective tissue graft (CTG) to guided bone regeneration (GBR) improves clinical and radiographic outcomes in surgical peri\u2010implantitis treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Thirty\u2010two patients with peri\u2010implantitis were randomly assigned to receive GBR and CTG (test group, TG) or GBR alone (control group, CG). Clinical and radiographic parameters were recorded at baseline, 6, and 12\u2009months. The primary outcome was the change in clinical attachment level (CAL), while secondary outcomes included pocket probing depth (PPD), bleeding on probing (BoP), plaque index (PI), keratinized mucosa width (KMW), mucosal thickness (MT), recession (REC), suppuration (SUP), marginal bone levels (MBL), bone defect morphology, and disease resolution (DR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 12\u2009months, CAL gain was significantly higher in TG compared with CG (3.21\u2009\u00b1\u20091.57\u2009mm vs. 1.65\u2009\u00b1\u20091.28\u2009mm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022), and TG achieved significantly greater increase in KMW (2.25\u2009\u00b1\u20092.89\u2009mm vs. 0.26\u2009\u00b1\u20091.49\u2009mm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010). Both groups showed significant PPD reduction, with a greater, though not statistically significant, improvement comparing TG with CG (3.25\u2009\u00b1\u20091.59\u2009mm vs. 1.97\u2009\u00b1\u20091.23\u2009mm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.052). Additionally, MBL improved significantly in both groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with higher gains in TG (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). However, DR was comparable between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GBR effectively improves peri\u2010implant parameters after 1\u2009year. Adding a CTG enhances CAL and KMW gains and may promote more favorable bone levels, although the impact on DR remains inconclusive. Long\u2010term studies are warranted to confirm these findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      NCT04323540\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.70093","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T09:00:52Z","timestamp":1769850052000},"page":"478-495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Connective Tissue Graft as an Adjunct to Guided Bone Regeneration in the Surgical Treatment of Peri\u2010Implantitis: A Dual\u2010Center Randomized Controlled Trial"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1397-0984","authenticated-orcid":false,"given":"Lucrezia Paterno","family":"Holtzman","sequence":"first","affiliation":[{"name":"Periodontology and Prosthodontics, George Eastman Dental Hospital University Policlinic \u201cLa Sapienza\u201d  Rome Italy"},{"name":"Dipartimento di Scienze Orali e Maxillofaciali Universit\u00e0 \u201cLa Sapienza\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5664-7848","authenticated-orcid":false,"given":"Iva","family":"Milinkovic","sequence":"additional","affiliation":[{"name":"Implant Center, School of Dental Medicine University of Belgrade  Belgrade Republic of Serbia"},{"name":"Department of Periodontology and Oral Medicine, School of Dental Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1379-6717","authenticated-orcid":false,"given":"Marija","family":"Vuckovic","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Medicine, School of Dental Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6067-5151","authenticated-orcid":false,"given":"Chiara","family":"Malpassi","sequence":"additional","affiliation":[{"name":"Periodontology and Prosthodontics, George Eastman Dental Hospital University Policlinic \u201cLa Sapienza\u201d  Rome Italy"},{"name":"Department of Medical Biotechnologies, Unit of Periodontology, Endodontology and Restorative Dentistry University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8695-6518","authenticated-orcid":false,"given":"Marla","family":"Cuppini","sequence":"additional","affiliation":[{"name":"Periodontology and Prosthodontics, George Eastman Dental Hospital University Policlinic \u201cLa Sapienza\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8161-4738","authenticated-orcid":false,"given":"Alex","family":"Solderer","sequence":"additional","affiliation":[{"name":"Clinic of Conservative and Preventive Dentistry, Center for Dental Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0390-8789","authenticated-orcid":false,"given":"Zoran","family":"Aleksic","sequence":"additional","affiliation":[{"name":"Implant Center, School of Dental Medicine University of Belgrade  Belgrade Republic of 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