{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:16:41Z","timestamp":1791821801917,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011970","name":"International Team for Implantology","doi-asserted-by":"publisher","award":["1218_2017"],"award-info":[{"award-number":["1218_2017"]}],"id":[{"id":"10.13039\/501100011970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the clinical performance of two\u2010piece zirconia implants with screw\u2010retained abutments compared to titanium implants after 1 year of loading.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      In this multicenter, prospective, randomized clinical trial, 61 two\u2010piece zirconia and 61 titanium implants were placed and restored with single crowns. Evaluations were performed at implant placement, crown delivery, and 1\u2010year post\u2010loading. Peri\u2010implant Marginal Bone Loss (MBL), survival rate, early wound healing index, and soft tissue parameters were assessed. Intergroup comparisons of continuous outcomes were performed using Linear Mixed\u2010Effects Models accounting for center and potential confounders. Categorical variables were analyzed using the chi\u2010square or Fisher's exact test. Survival was analyzed using Kaplan\u2013Meier estimates. Significance was set at\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No significant differences were found between the two implant types. Mean MBL from implantation to crown insertion was 1.10\u2009\u00b1\u20090.78\u2009mm for titanium and 0.94\u2009\u00b1\u20090.67\u2009mm for zirconia implants. No significant additional bone loss occurred over the subsequent year, with changes of 0.07\u2009\u00b1\u20090.55\u2009mm and 0.08\u2009\u00b1\u20090.51\u2009mm for titanium and zirconia, respectively. After 1 year, zirconia implants showed a 100% survival rate, while titanium implants showed 96.5% with two failures. At 1 year, differences in probing depths, plaque accumulation, and Papilla Bleeding Index were not statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>After 1 year of loading, no statistically significant differences in MBL, implant survival, or peri\u2010implant health were found between zirconia and titanium implants, indicating no clinical superiority. Zirconia implants may therefore be considered a viable alternative in single\u2010tooth implant restorations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>The study is registered at the German Clinical Trial Register (No. DRKS 00013209) as well as at the Federal Office of Public Health's (FOPH) portal for human research in Switzerland (kofam.ch)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.70094","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T03:53:47Z","timestamp":1769140427000},"page":"496-508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["One\u2010Year Analysis of Clinical and Radiological Outcomes of Two\u2010Piece Zirconia Compared to Titanium Implants: A Multicenter Prospective Randomized Clinical Trial"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0637-8314","authenticated-orcid":false,"given":"Marc","family":"Balmer","sequence":"first","affiliation":[{"name":"Clinic of Reconstructive Dentistry, Center for Dental Medicine Zurich University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4469-8335","authenticated-orcid":false,"given":"Michael","family":"Payer","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Orthodontics, University Clinic for Dental Medicine &amp; Oral Health Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3738-0012","authenticated-orcid":false,"given":"Anke","family":"Steinwender","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Periodontology and Prosthodontics, University Clinic for Dental Medicine &amp; Oral Health Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8278-6857","authenticated-orcid":false,"given":"Valentin","family":"Herber","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, University Center for Dental Medicine in Basel University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2055-1320","authenticated-orcid":false,"given":"Ronald E.","family":"Jung","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry, Center for Dental Medicine Zurich University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3174-135X","authenticated-orcid":false,"given":"Sebastian","family":"K\u00fchl","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, University Center for Dental Medicine in Basel University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20103913(93)90289\u2010Z"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5592934"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100501.2009.01785.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13581"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12610"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/JCPE.12957"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13411"},{"issue":"1","key":"e_1_2_11_9_1","first-page":"69","article-title":"Soft and Hard Tissue Response to Zirconium Dioxide Dental Implants\u2014A Clinical Study in Man","volume":"27","author":"Blaschke C.","year":"2006","journal-title":"Neuroendocrinology Letters"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12704"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp\u2010journals\u201010024\u20101364"},{"issue":"2","key":"e_1_2_11_12_1","first-page":"95","article-title":"A Comparative Study of Results With Various Endosseous Implant Systems","volume":"4","author":"d'Hoedt B.","year":"1989","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"issue":"1","key":"e_1_2_11_13_1","first-page":"22","article-title":"Implant Failure due to Titanium Hypersensitivity\/Allergy?\u2014Report of a Case: Implantology Corner","volume":"62","author":"Preez L. 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