{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:13:40Z","timestamp":1783455220207,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To develop and validate an interpretable machine learning (ML) model for early prediction of peri\u2010implant mucositis (PIM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>This retrospective study enrolled patients receiving dental implants between October 2011 to June 2023 in our cohort to develop a ML\u2010based model. External testing was subsequently performed utilizing datasets from two other hospitals. The least absolute shrinkage and selection operator (LASSO) was utilized for feature selection. Six ML algorithms were applied to analyze and identify the optimal model. Shapley Additive exPlanations (SHAP) interpretation was developed for model interpretation and personalized risk assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 341 patients with 605 implants were included in our cohort and 101 patients with 170 implants were included in the external testing cohort. The Area Under Curves (AUCs) and Brier scores of the Support Vector Machine (SVM) model with 10 features were 0.902 and 0.129 in the validation set, while 0.797 and 0.256 in the external testing cohort, demonstrating superior discrimination and calibration compared to other algorithms. The SHAP algorithm interpreted that inadequate keratinized mucosa width, poor oral hygiene, restoration type (splinted crown\/bridge), free\u2010end edentulism, gingivitis, smoking habit, thin gingival biotype, and cement\u2010retained restoration would elevate the occurrence of PIM. On the contrary, use of interproximal brushing\/flossing and use of oral irrigator served as protective factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study developed the first interpretable ML\u2010based tool for predicting PIM in patients with dental implant placement after 1\u2010year, with the SVM model showing high discriminative ability and clinical utility for risk stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.70125","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T04:01:19Z","timestamp":1775448079000},"page":"806-820","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and Validation of a Machine Learning\u2010Based Model to Predict Peri\u2010Implant Mucositis in Patients With Dental Implant Placement After 1\u2010Year"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4686-6307","authenticated-orcid":false,"given":"Lin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of General Dentistry The Affiliated Stomatological Hospital of Nanjing Medical University  Nanjing China"},{"name":"State Key Laboratory Cultivation Base of Research Prevention and Treatment for Oral Diseases (Nanjing Medical University)  Nanjing China"},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine (Nanjing Medical University)  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Stomatology The Second Affiliated Hospital of Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulei","family":"Qian","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Electromagnetic Effect and Security on Marine Equipment  Nanjing China"},{"name":"Nanjing Marine Radar Institute  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of General Dentistry The Affiliated Stomatological Hospital of Nanjing Medical University  Nanjing China"},{"name":"State Key Laboratory Cultivation Base of Research Prevention and Treatment for Oral Diseases (Nanjing Medical University)  Nanjing China"},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine (Nanjing Medical University)  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cultivation Base of Research Prevention and Treatment for Oral Diseases (Nanjing Medical University)  Nanjing China"},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine (Nanjing Medical University)  Nanjing China"},{"name":"Department of Stomatology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cultivation Base of Research Prevention and Treatment for Oral Diseases (Nanjing Medical University)  Nanjing China"},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine (Nanjing Medical University)  Nanjing China"},{"name":"Department of Dental Implantology The Affiliated Stomatological Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belal O. M.","family":"Muhaisen","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cultivation Base of Research Prevention and Treatment for Oral Diseases (Nanjing Medical University)  Nanjing China"},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine (Nanjing Medical University)  Nanjing China"},{"name":"Department of Dental Implantology The Affiliated Stomatological Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0286-004X","authenticated-orcid":false,"given":"Chunbo","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cultivation Base of Research Prevention and Treatment for Oral Diseases (Nanjing Medical University)  Nanjing China"},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine (Nanjing Medical University)  Nanjing China"},{"name":"Department of Dental Implantology The Affiliated Stomatological Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.13400"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.23-0355"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12957"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13638"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2023-078378"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpor.2016.03.004"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12290"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13896"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-02902-1"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.24-0154"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41405-025-00301-3"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-024-05138-0"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13585"},{"issue":"20","key":"e_1_2_11_15_1","first-page":"S237","article-title":"Peri\u2010Implant Mucositis","volume":"45","author":"Heitz\u2010Mayfield L. 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