{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:00:48Z","timestamp":1787785248836,"version":"build-2784847793"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["202308330121"],"award-info":[{"award-number":["202308330121"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2023C03070"],"award-info":[{"award-number":["2023C03070"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2026C02A1139"],"award-info":[{"award-number":["2026C02A1139"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To screen decontamination efficacy of three combinatory protocols and to evaluate the regenerative efficacy of bone morphogenetic protein 2\u2010incorporated biomimetic calcium phosphate granules (BMP2\u2010inc. BioCaP) in treating implants with peri\u2010implantitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Peri\u2010implantitis model was established on 24 dental implants in 6 beagle dogs. The implants were decontaminated using mechanical curettage (MC) with either Chlorhexidine (CHX), photodynamic therapy (PDT), or both. The decontamination efficacy was assessed by measuring modified Sulcus Bleeding Index (mSBI), probing pocket depth (PPD), peri\u2010implant sulcular fluid (PISF), and inflammatory cytokines of crevicular fluid (IL\u20108, IL\u20101\u03b2). Thereafter, GBR surgery was performed either without (Control) or with deproteinized bovine bone mineral (DBBM) or with BMP2\u2010inc. BioCaP. Three fluoresceins were consequentially injected to assess bone growth rates. Eight weeks post\u2010surgery, samples were subjected to micro\u2010CT, confocal laser scanning microscopy and histomorphometric analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MC\u2009+\u2009CHX\u2009+\u2009PDT was associated with the lowest levels of mSBI, PPD, PISF, IL\u20101\u03b2, and IL\u20108 2\u2009weeks post decontamination. Eight weeks post GBR surgery, BMP2\u2010inc. BioCaP yielded significantly higher bone volume fraction, trabecular thickness, trabecular number, bone mineral density, and significantly lower trabecular separation than DBBM and Control. BMP2\u2010inc. BioCaP bore significantly higher total fluorescence intensities than DBBM and Control at 2, 4, and 6\u2009weeks, and was also associated with significantly higher bone\u2010to\u2010implant contact and new bone height than DBBM and Control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Within the limitations of this study, MC\u2009+\u2009CHX\u2009+\u2009PDT decontamination and BMP\u20102\u2010incorporated BioCaP showed an application potential in treating peri\u2010implantitis. Further studies with a long monitoring span are necessary before clinical application.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.70126","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T03:55:56Z","timestamp":1775706956000},"page":"821-834","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Efficacy of Three Combinatory Decontamination Protocols and\n                    <scp>BMP<\/scp>\n                    \u20102\u2010Incorporated\n                    <scp>BioCaP<\/scp>\n                    \u2010Based Regenerative Material in Treating Implants With Peri\u2010Implantitis In\u00a0Vivo"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8923-7742","authenticated-orcid":false,"given":"Ting","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Leiden University Medical Center (LUMC)  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Stomatology Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7942-8533","authenticated-orcid":false,"given":"Tymour","family":"Forouzanfar","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Leiden University Medical Center (LUMC)  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Stomatology Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zimu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Stomatology The Second Affiliated Hospital of Jiaxing University  Jiaxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1466-863X","authenticated-orcid":false,"given":"Ping","family":"Sun","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8941-2500","authenticated-orcid":false,"given":"Gang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Leiden University Medical Center (LUMC)  Leiden the Netherlands"},{"name":"Savid School of Stomatology Hangzhou Medical College  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4561-8731","authenticated-orcid":false,"given":"Haiyan","family":"Lin","sequence":"additional","affiliation":[{"name":"Savid School of Stomatology Hangzhou Medical College  Hangzhou China"},{"name":"Department of Implantology Hangzhou Stomatology Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"issue":"2","key":"e_1_2_11_2_1","first-page":"135","article-title":"Comparisons Between Bio\u2010Oss(\u00ae) Straumann(\u00ae) Bone Ceramic in Immediate and Staged Implant Placement in Dogs Mandible Bone Defects","volume":"24","author":"Antonio A.","year":"2011","journal-title":"Clinical Oral Implants Research"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2016.03.015"},{"issue":"4","key":"e_1_2_11_4_1","first-page":"533","article-title":"Experimentally 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