{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:11:35Z","timestamp":1791807095072,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This RCT evaluated and compared the clinical performance of zirconia and titanium dental implants placed in the maxillary premolar region. Outcomes were assessed 3\u2009years after prosthetic loading and included marginal bone level (MBL) changes, clinical parameters, aesthetic outcomes, and patient related outcome measures (PROMs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Fifty patients were randomly allocated to receive either a zirconia one\u2010piece (ZrO\n                      <jats:sub>2<\/jats:sub>\n                      ,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200925) implant or a titanium bone\u2010level (Ti,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200925) implant, restored with a lithium disilicate crown 3 months after implant placement. Primary outcome was change in MBL. Secondary outcomes included implant survival, peri\u2010implant tissue health, technical complications, aesthetic outcomes, and PROMs. Examinations were performed 3\u2009years after crown placement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 3\u2009years, mean MBL change was \u22120.02\u2009mm (SD\u2009=\u20090.78) for ZrO\n                      <jats:sub>2<\/jats:sub>\n                      and \u22120.04\u2009mm (SD\u2009=\u20090.36) for Ti; no statistically significant difference was found (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.635). One ZrO\n                      <jats:sub>2<\/jats:sub>\n                      implant failed to osseointegrate. Clinical parameters were favourable for both implant types, although slightly higher bleeding scores were observed for ZrO\n                      <jats:sub>2<\/jats:sub>\n                      . Differences in aesthetic outcomes and PROMs were found, favoring the ZrO\n                      <jats:sub>2<\/jats:sub>\n                      implant group. None of these differences reached statistical significance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Clinical Implications<\/jats:title>\n                    <jats:p>\n                      After 3\u2009years of function, the ZrO\n                      <jats:sub>2<\/jats:sub>\n                      and Ti implant as applied in this study showed comparable MBL changes. Survival, clinical and aesthetic parameters, and PROMs were generally favourable and largely comparable for both groups. These short\u2010term findings indicate that both implant types represent a viable option for clinical use in this application.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>CCMO registration: NL58957.042.16<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.70148","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:46:00Z","timestamp":1781757960000},"page":"1069-1080","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Randomised Controlled Trial Comparing a One\u2010Piece Zirconia Tissue\u2010Level Implant and Two\u2010Piece Titanium Bone\u2010Level Implant for Maxillary Single Tooth Replacement\u20143\u2009year Results"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2811-4427","authenticated-orcid":false,"given":"J. H. W.","family":"de Beus","sequence":"first","affiliation":[{"name":"Department of Dentistry Orthodontics, Section of Restorative Dentistry University of Groningen, University Medical Center Groningen  Groningen the Netherlands"},{"name":"Department of Oral Maxillofacial Surgery University of Groningen, University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. S.","family":"Cune","sequence":"additional","affiliation":[{"name":"Department of Dentistry Orthodontics, Section of Restorative Dentistry University of Groningen, University Medical Center Groningen  Groningen the Netherlands"},{"name":"Department of Oral Maxillofacial Surgery, Prosthodontics and Special Dental Care St. Antonius Hospital  Nieuwegein the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Muijselaar","sequence":"additional","affiliation":[{"name":"Department of Dentistry Orthodontics, Section of Restorative Dentistry University of Groningen, University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8318-4113","authenticated-orcid":false,"given":"J. W. A.","family":"Slot","sequence":"additional","affiliation":[{"name":"Department of Dentistry Orthodontics, Section of Restorative Dentistry University of Groningen, University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Jensen\u2010Louwerse","sequence":"additional","affiliation":[{"name":"Department of Dentistry Orthodontics, Section of Restorative Dentistry University of Groningen, University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"la Bastide\u2010van Gemert","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Groningen, University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1702-6031","authenticated-orcid":false,"given":"H. J. A.","family":"Meijer","sequence":"additional","affiliation":[{"name":"Department of Dentistry Orthodontics, Section of Restorative Dentistry University of Groningen, University Medical Center Groningen  Groningen the Netherlands"},{"name":"Department of Oral Maxillofacial Surgery University of Groningen, University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3578-7141","authenticated-orcid":false,"given":"G. M.","family":"Raghoebar","sequence":"additional","affiliation":[{"name":"Department of Oral Maxillofacial Surgery University of Groningen, University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5995-0735","authenticated-orcid":false,"given":"U.","family":"Schepke","sequence":"additional","affiliation":[{"name":"Department of Dentistry Orthodontics, Section of Restorative Dentistry University of Groningen, University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14135"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2016.01.004"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080435"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17\u20100739"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma13030562"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14258"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19113585"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.15010"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3758\/bf03193146"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12718"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100501.2005.01193.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12598"},{"issue":"3","key":"e_1_2_11_14_1","first-page":"247","article-title":"Single Crowns in the Resorbed Posterior Maxilla Supported by Either 6\u2010Mm Implants or by 11\u2010Mm Implants Combined With Sinus Floor Elevation Surgery: A 1\u2010Year Randomised Controlled Trial","volume":"7","author":"Gulj\u00e9 F. 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