{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:13:10Z","timestamp":1788509590044,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007619","name":"Osteology Foundation","doi-asserted-by":"publisher","award":["10\u2010026"],"award-info":[{"award-number":["10\u2010026"]}],"id":[{"id":"10.13039\/501100007619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>To assess the 5\u2010year dimensional stability of buccal hard\u2010tissues following guided bone regeneration (GBR) of peri\u2010implant dehiscence defects using deproteinized bovine bone mineral (DBBM) blocks or particulate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients requiring single\u2010tooth implants and presenting a buccal dehiscence defect (\u2265\u20093\u2009mm) at implant placement were randomly allocated to GBR using either particulate DBBM or an individually shaped DBBM\u2010block, both covered with a resorbable collagen membrane. Buccal hard\u2010tissue thickness was assessed using cone\u2010beam computed tomography postoperatively, at 6\u2009months and at 5\u2009years. Buccal horizontal thickness at the implant shoulder and corono\u2010buccal thickness measured at 45\u00b0 were recorded. Secondary outcomes included marginal bone levels, clinical parameters and implant survival. Linear mixed\u2010effects models were used to compare the groups to account for within\u2010subject correlations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010two of 24 patients completed the 5\u2010year follow\u2010up. Buccal hard\u2010tissue thickness decreased over time in both groups, however, the block\u2010group showed significantly greater dimensional stability. At 5\u2009years, mean buccal horizontal hard\u2010tissue thickness was 1.36\u2009\u00b1\u20091.16\u2009mm in the block\u2010group and 0.07\u2009\u00b1\u20090.16\u2009mm in the particulate\u2010group (adjusted mean difference, \u22121.2\u2009mm; 95% CI, \u22121.9 to\u22120.6;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Corono\u2010buccal thickness at 45\u00b0 was also significantly greater in the block\u2010group (adjusted mean difference, \u22120.3\u2009mm; 95% CI, \u22120.5 to \u22120.1;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). Marginal bone levels and clinical parameters showed no clinically relevant differences. No implant loss or peri\u2010implantitis was observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>GBR using either DBBM blocks or particulate DBBM resulted in similar peri\u2010implant clinical outcomes and implant survival at 5\u2009years. However, DBBM blocks provided superior long\u2010term preservation of the buccal hard\u2010tissue contour.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Clinical Trial Registration Number, DRKS00005803<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.70150","type":"journal-article","created":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T15:17:21Z","timestamp":1782659841000},"page":"1096-1108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Block Versus Particulate Deproteinized Bovine Bone Mineral for Guided Bone Regeneration of Peri\u2010Implant Dehiscence Defects: A 5\u2010Year Randomized Controlled Trial"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9941-3491","authenticated-orcid":false,"given":"Anina N.","family":"Zuercher","sequence":"first","affiliation":[{"name":"Clinic of Reconstructive Dentistry, Center of Dental Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkan","family":"Evci","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry, Center of Dental Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6271-5325","authenticated-orcid":false,"given":"Riccardo D.","family":"Kraus","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry, Center of Dental Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2055-1320","authenticated-orcid":false,"given":"Ronald E.","family":"Jung","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry, Center of Dental Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5832-7327","authenticated-orcid":false,"given":"Franz J.","family":"Strauss","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry, Center of Dental Medicine University of Zurich  Zurich Switzerland"},{"name":"Universidad Autonoma de Chile  Santiago Chile"},{"name":"Faculty of Dentistry, Universidad Finis Terrae  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goran","family":"Benic","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry, Center of Dental Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13583"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2005.00726.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13515"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12616"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12039"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100501.2011.02253.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13011"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12625"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12957"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534\u2010198805000\u201000004"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13587"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12334"},{"issue":"4","key":"e_1_2_11_14_1","first-page":"429","article-title":"Horizontal Bone Augmentation: The Decision Tree","volume":"31","author":"Fu J. 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