{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:13:10Z","timestamp":1788509590029,"version":"build-2803163510"},"reference-count":104,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:00:00Z","timestamp":1783209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:00:00Z","timestamp":1783209600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this scoping review was to evaluate the effect of systemic medications on dental implant outcomes in medically compromised patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Electronic and manual searches were conducted for this scoping review. Clinical studies reporting on systemic medication intake and implant outcomes were eligible. Studies reporting on the use of antiresorptive medications were not included in this scoping review. Qualitative evaluation was performed as meta\u2010analysis was not feasible due to study heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 51 studies met the inclusion criteria and were eligible for assessment. Six medications were identified to potentially impact the short\u2010 and long\u2010term implant outcomes. In total, 8 studies reported the intake of anti\u2010hypertensives (AHTNs), 9 studies reported the intake of anticoagulants (ACs), 12 studies reported the intake of immunosuppressants (IMNs), 11 studies reported the intake of nonsteroidal anti\u2010inflammatories (NSAIDs), 12 studies reported the intake of proton\u2010pump inhibitors (PPIs), and 12 studies reported the intake of selective serotonin reuptake inhibitors (SSRIs). Moreover, 1 study reported pooled data regarding the use of PPIs, SSRIs, AHTNs, and statins. From these, the following results were drawn: ACs, long\u2010term NSAID use, prolonged use of PPIs, and SSRIs are associated with increased risk of implant failure and\/or marginal bone loss. Additionally, AHTNs and IMNs have no effect on implant\u2010related outcomes. Medication\u2010related biological implant complications are underreported in the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Medication intake can significantly influence implant\u2010related outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.70151","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T03:57:03Z","timestamp":1783310223000},"page":"1033-1056","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Medication Intake on Dental Implant\u2010Related Outcomes\u2014A Scoping Review"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8292-1927","authenticated-orcid":false,"given":"Alberto","family":"Monje","sequence":"first","affiliation":[{"name":"Department of Periodontology Universitat Internacional de Catalunya  Barcelona Spain"},{"name":"Department of Periodontology University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Costanza","family":"Soldini","sequence":"additional","affiliation":[{"name":"Department of Periodontology Universitat Internacional de Catalunya  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9989-4483","authenticated-orcid":false,"given":"Emilio","family":"Couso\u2010Queiruga","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Stomatology University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1355-8700","authenticated-orcid":false,"given":"\u00c1lvaro","family":"Babiano","sequence":"additional","affiliation":[{"name":"Department of Periodontology Universitat Internacional de Catalunya  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivianne","family":"Chappuis","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Stomatology University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.04.031"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.31661\/gmj.v13iSP1.3666"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202111_27251"},{"issue":"3","key":"e_1_2_10_5_1","first-page":"185","article-title":"Influence of Ibuprofen on Bone Healing Around Dental Implants: A Randomised Double\u2010Blind Placebo\u2010Controlled Clinical Study","volume":"2","author":"Alissa R.","year":"2009","journal-title":"European Journal of Oral Implantology"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1563\/aaid\u2010joi\u2010D\u201017\u201000240"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.5125\/jkaoms.2019.45.3.135"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2018.02.003"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.081006"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.461"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100501.2010.01963.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.10199"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M411961200"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2025.02.005"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198\u2010006\u20100259\u2010y"},{"key":"e_1_2_10_16_1","first-page":"12","article-title":"Systemic Conditions and Treatments as Risks for Implant Therapy","volume":"24","author":"Bornstein M. 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