{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:31:27Z","timestamp":1788543087861,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Evaluate the efficacy of adjunctive mechanical\/physical decontamination to non\u2010surgical submarginal instrumentation in patients with peri\u2010implantitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Patients with at least one implant diagnosed with peri\u2010implantitis were included in this 6\u2010month single\u2010masked randomized clinical trial with three parallel groups: non\u2010surgical submarginal instrumentation with titanium curettes (control); control plus erythritol air\u2010polishing (test 1) and control plus Er:YAG laser (test 2). Clinical variables were collected at baseline, 1, 3 and 6\u2009months. The primary outcome was probing pocket depth (PPD) reduction. Secondary outcomes included bleeding on probing (BoP) reduction and endpoint of therapy (implants with PPD \u2264\u20095\u2009mm, BoP \u2264\u20091 site, no suppuration). A multilevel logistic model was computed to evaluate the predictive value of implant\u2010 and patient\u2010level variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty\u2010seven patients (84 implants) were enrolled. PPD reductions were observed in all groups (mean: 1\u20131.4\u2009mm at 1\u2009month), remaining stable at 3\u2009months, with slight relapse at 6\u2009months. All treatments led to significant BoP reduction (24%\u201336%) at 1\u2009month, with no further significant changes at later follow\u2010ups and no intergroup differences. Therapeutic endpoint rates were 12%\u201318%. Multilevel analysis suggested an association between the presence of \u2265\u20092\u2009mm vestibular keratinized mucosa and the use of Er:YAG with higher odds of achieving treatment success. Healing was uneventful in all groups, except for one case of surgical emphysema associated with erythritol air\u2010polishing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Irrespective of the adjunctive treatment modality, achievement of peri\u2010implantitis therapeutic endpoint was limited across groups. Possible associations with treatment outcomes were observed; these findings require confirmation in larger studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT03451981\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.70153","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:21:16Z","timestamp":1782966076000},"page":"1118-1128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the Adjunctive Use of Er:\n                    <scp>YAG<\/scp>\n                    Laser or Erythritol Air\u2010Polishing in the Non\u2010Surgical Treatment of Peri\u2010Implantitis: A Pilot\n                    <scp>RCT<\/scp>"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1827-5200","authenticated-orcid":false,"given":"Marco","family":"Clementini","sequence":"first","affiliation":[{"name":"Department of Periodontology UniCamillus\u2010Saint Camillus International University of Health Sciences  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5299-1753","authenticated-orcid":false,"given":"Margherita","family":"Minoli","sequence":"additional","affiliation":[{"name":"Department of Periodontics Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1345-8744","authenticated-orcid":false,"given":"Simone","family":"Fabrizi","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies, Unit of Periodontics Universit\u00e0 Degli Studi di Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8704-5813","authenticated-orcid":false,"given":"Isabella","family":"De Rubertis","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies, Unit of Periodontics Universit\u00e0 Degli Studi di Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1805-2899","authenticated-orcid":false,"given":"Nicola","family":"Discepoli","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies, Unit of Periodontics Universit\u00e0 Degli Studi di Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5915-566X","authenticated-orcid":false,"given":"Massimo","family":"de Sanctis","sequence":"additional","affiliation":[{"name":"Department of Periodontology Vita\u2010Salute San Raffaele 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