{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:53:30Z","timestamp":1791381210015,"version":"4.3.3"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Given the proposed bioactive role of collagen membranes, we aimed to evaluate whether the perforation size of titanium\u2010reinforced dPTFE membranes, with or without an additional collagen membrane, influences outcomes of vertical alveolar ridge augmentation (VARA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      In 12 beagle dogs (24 sites), standardized bilateral chronic mandibular ridge defects (8\u2009\u00d7\u200930\u2009mm) were created and healed for 12\u2009weeks. Sites were randomized (1:1:1) to VARA using porcine xenograft covered with either: (i) non\u2010perforated titanium\u2010reinforced dPTFE (NON\u2010PERF), (ii) perforated titanium\u2010reinforced dPTFE (PERF), or (iii) perforated titanium\u2010reinforced dPTFE covered by a collagen membrane (PERF+CM). After 16\u2009weeks, specimens underwent micro\u2010CT, histology\/histomorphometry, vessel quantification, and immunohistochemistry (OCN, ALP, VEGF, TRAP). Continuous outcomes were summarized as medians and compared using the Kruskal\u2013Wallis test with Dunn's post hoc testing when applicable; inflammatory cell scores were analyzed using ordinal logistic regression (\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2009=\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 24 treated sites, four had complications and were excluded. All remaining sites achieved around 60% new bone area with no significant intergroup differences (new bone\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.5047; soft tissue\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.2994; residual graft\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.9689). Linear vertical gain was comparable (medians 2.33, 2.87, 2.74\u2009mm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.7119). Micro\u2010CT outcomes did not differ (e.g., BV\/TV,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.2739). Ordinal models did not show significant group differences in inflammatory scores; plasma cell scores in PERF+CM versus control were borderline (OR 15.61;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0587).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Perforated dPTFE membranes yielded comparable bone gain to unperforated dPTFE. Adding a collagen membrane over perforated dPTFE did not improve VARA outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.70157","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T05:54:54Z","timestamp":1784526894000},"page":"1158-1171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Membrane Perforations With and Without Collagen Membrane Coverage in Vertical Ridge Augmentation: An Experimental Pilot In\u00a0Vivo Study"],"prefix":"10.1111","volume":"37","author":[{"given":"Istvan A.","family":"Urban","sequence":"first","affiliation":[{"name":"Urban Regeneration Institute  Budapest Hungary"},{"name":"Department of Periodontics and Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e1ndor","family":"Farkasdi","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Faculty of Dentistry Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5067-7317","authenticated-orcid":false,"given":"Muhammad H. A.","family":"Saleh","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Lopez","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Universidad de De Santiago de Compostela  Lugo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4130-1526","authenticated-orcid":false,"given":"Fernando","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Universidad de De Santiago de Compostela  Lugo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor","family":"Varga","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"},{"name":"Department of Oral Biology Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio G.","family":"Araujo","sequence":"additional","affiliation":[{"name":"State University of Maring\u00e1  Maring\u00e1 Brazil"},{"name":"Private Practice in Dental Implants and Periodontics  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Vignoletti","sequence":"additional","affiliation":[{"name":"Department of Periodontology Complutense University of Madrid  Madrid Spain"},{"name":"Thinking Perio Research, Studio Dentistico Vignoletti  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2012.06.003"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100765.1997.tb01397.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.6373"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100714.1982.tb00172.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12364"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina61071269"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1364\/JOSAA.1.000612"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.70079"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2008.11.022"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13121"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100501.2012.02534.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.22203\/ecm.v015a08"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100501.1994.050202.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051x.1995.tb00142.x"},{"issue":"1","key":"e_1_2_11_16_1","first-page":"9","article-title":"Effect of Triiodothyronine Treatment, Thyroparathyroidectomy and Mercaptoiminazole Treatment on Enchondral Bone Growth. 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