{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:53:31Z","timestamp":1791381211537,"version":"4.3.3"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007619","name":"Osteology Foundation","doi-asserted-by":"publisher","award":["21\u201004"],"award-info":[{"award-number":["21\u201004"]}],"id":[{"id":"10.13039\/501100007619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007619","name":"Osteology Foundation","doi-asserted-by":"publisher","award":["23\u2010038"],"award-info":[{"award-number":["23\u2010038"]}],"id":[{"id":"10.13039\/501100007619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007619","name":"Osteology Foundation","doi-asserted-by":"publisher","award":["IADR\u2010OF New Investigator Award 2022"],"award-info":[{"award-number":["IADR\u2010OF New Investigator Award 2022"]}],"id":[{"id":"10.13039\/501100007619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016190","name":"Trond Mohn stiftelse","doi-asserted-by":"publisher","award":["TMS2021TMT08"],"award-info":[{"award-number":["TMS2021TMT08"]}],"id":[{"id":"10.13039\/100016190","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004257","name":"Helse Vest","doi-asserted-by":"publisher","award":["F\u201012124"],"award-info":[{"award-number":["F\u201012124"]}],"id":[{"id":"10.13039\/501100004257","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the efficacy of mesenchymal stromal cells' (MSC) secretome delivered as conditioned media (CM) as an adjunct to a xenograft (XG) and collagen membrane (MEM) for guided bone regeneration (GBR) in chronic non\u2010contained mandibular defects in minipigs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Chronic bilateral mandibular defects were surgically created in seven minipigs. In a split\u2010mouth design, defects were treated with either CM\u2010functionalized (test) or native XG\u2009+\u2009MEM (control) and evaluated after 4 and 12\u2009weeks. New bone formation was assessed using in\u00a0vivo computed tomography (CT) and ex\u00a0vivo micro\u2010CT, histology and immunohistochemistry (IHC). Quantitative CT, micro\u2010CT and histomorphometric data were statistically analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No significant differences in new bone formation were observed between the test and control group at either timepoint. These findings could be partly explained by a high intrinsic healing capacity and continual growth of the animals. Minimal residual XG material was detected in both groups at 4 and 12\u2009weeks. When present, these remnants were associated with multinucleated Cathepsin K\u2010positive cells (IHC) with no observable differences between the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The adjunctive use of\n                      <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>\n                      secretome in combination with\n                      <jats:styled-content style=\"fixed-case\">XG<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">MEM<\/jats:styled-content>\n                      did not improve\n                      <jats:styled-content style=\"fixed-case\">GBR<\/jats:styled-content>\n                      outcomes in chronic non\u2010contained mandibular defects in the present minipig model. The suitability of this animal model for experimental\n                      <jats:styled-content style=\"fixed-case\">GBR<\/jats:styled-content>\n                      may be questionable.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.70164","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:48:20Z","timestamp":1785732500000},"page":"1217-1229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Adjunctive Use of MSC Secretome for Guided Bone Regeneration: An Experimental In\u00a0Vivo Investigation"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0056-8379","authenticated-orcid":false,"given":"Siddharth","family":"Shanbhag","sequence":"first","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry University of Oslo  Oslo Norway"},{"name":"Center for Translational Oral Research (TOR), Department of Clinical Dentistry, Faculty of Medicine University of Bergen  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0859-3149","authenticated-orcid":false,"given":"Javier","family":"Sanz\u2010Esporrin","sequence":"additional","affiliation":[{"name":"ETEP Research Group, University Complutense of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Nu\u00f1ez","sequence":"additional","affiliation":[{"name":"ETEP Research Group, University Complutense of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8106-6615","authenticated-orcid":false,"given":"Fernando","family":"Luengo","sequence":"additional","affiliation":[{"name":"ETEP Research Group, University Complutense of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Toledano\u2010Osorio","sequence":"additional","affiliation":[{"name":"ETEP Research Group, University Complutense of Madrid  Madrid Spain"},{"name":"Department of Stomatology, Faculty of Dentistry University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Kampleitner","sequence":"additional","affiliation":[{"name":"Karl Donath Laboratory for Hard Tissue and Biomaterial Research, Division of Oral Surgery University Clinic of Dentistry, Medical University of Vienna  Vienna Austria"},{"name":"Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, the Research Center in Cooperation With AUVA  Vienna Austria"},{"name":"Austrian Cluster for Tissue Regeneration  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Heimel","sequence":"additional","affiliation":[{"name":"Karl Donath Laboratory for Hard Tissue and Biomaterial Research, Division of Oral Surgery University Clinic of Dentistry, Medical University of Vienna  Vienna Austria"},{"name":"Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, the Research Center in Cooperation With AUVA  Vienna Austria"},{"name":"Austrian Cluster for Tissue Regeneration  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Sch\u00e6dl","sequence":"additional","affiliation":[{"name":"Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, the Research Center in Cooperation With AUVA  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Javier Vela","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Microsurgery Uniit, Jes\u00fas Us\u00f3n Minimally Invasive Surgery Centre  C\u00e1ceres Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samih","family":"Mohamed\u2010Ahmed","sequence":"additional","affiliation":[{"name":"Center for Translational Oral Research (TOR), Department of Clinical Dentistry, Faculty of Medicine University of Bergen  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7581-6413","authenticated-orcid":false,"given":"Cecilie","family":"Gjerde","sequence":"additional","affiliation":[{"name":"Center for Translational Oral Research (TOR), Department of Clinical Dentistry, Faculty of Medicine University of Bergen  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5400-9009","authenticated-orcid":false,"given":"Reinhard","family":"Gruber","sequence":"additional","affiliation":[{"name":"Austrian Cluster for Tissue Regeneration  Vienna Austria"},{"name":"Department of Oral Biology University Clinic of Dentistry, Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Center for Translational Oral Research (TOR), Department of Clinical Dentistry, Faculty of Medicine University of Bergen  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6293-5755","authenticated-orcid":false,"given":"Mariano","family":"Sanz","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry University of Oslo  Oslo Norway"},{"name":"ETEP Research Group, University Complutense of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,2]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cre2.414"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02198.x"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12539"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12361"},{"issue":"5","key":"e_1_2_13_6_1","article-title":"Intrapericardial Administration of Secretomes From Menstrual Blood\u2010Derived Mesenchymal Stromal Cells: Effects on Immune\u2010Related Genes in a Porcine Model of Myocardial Infarction","volume":"10","author":"Pedro M. A.","year":"2022","journal-title":"Biomedicine"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-023-05079-y"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/2041731418776819"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.70026"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2012.00445.x"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.24811"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.113961"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.01.010"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.10.034"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.66.599"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.11.074"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2005.01257.x"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.5051\/jpis.2204660233"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2019.00352"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105145"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.01939.x"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.70011"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP088870"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2017.0109"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2009.06.037"},{"issue":"1","key":"e_1_2_13_26_1","first-page":"43","article-title":"The Biodegradation of Hydroxyapatite Bone Graft Substitutes In\u00a0Vivo","volume":"65","author":"Rumpel E.","year":"2006","journal-title":"Folia Morphologica"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13014"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14205"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12050767"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14253"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.70007"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.2198"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13049"},{"key":"e_1_2_13_34_1","unstructured":"Siufui H. Q.Sandy K.Ronald Winardi K.Vera andL.David Victorious.2021.\u201cSevere COVID\u201019 Treatment Using Hypoxic\u2010Mesenchymal Stem Cell Secretome: A Case Report.\u201dPaper Presented at: Proceedings of the 1st Tarumanagara International Conference on Medicine and Health (TICMIH 2021)."},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12065"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13708"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2008.02.002"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2011.01.001"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12471"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-01937-8"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/03635465211068129"}],"container-title":["Clinical Oral Implants Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.70164","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/clr.70164","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.70164","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:09:27Z","timestamp":1791378567000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/clr.70164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,2]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/clr.70164"],"URL":"https:\/\/doi.org\/10.1111\/clr.70164","archive":["Portico"],"relation":{},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,2]]},"assertion":[{"value":"2026-04-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}