{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:00:53Z","timestamp":1790398853516,"version":"4.1.0"},"reference-count":94,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This retrospective cohort study evaluated patient\u2010, implant\u2010, site\u2010, procedural\u2010, biological\u2010, and prosthesis\/mechanics\u2010related factors associated with early and late implant failure and peri\u2010implantitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Electronic health record data from a university center were analyzed. Forty patient\u2010, implant\/site\u2010, biologic\u2010, and prosthesis\u2010related variables were evaluated in relation to early failure, late failure, and peri\u2010implantitis. Bivariate and survival analyses were performed, followed by mixed\u2010effects regression models appropriate to each outcome. Robustness was assessed via clustered bootstrap resampling, penalized regression, and sensitivity analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 264 patients and 554 implants were assessed. Cumulative implant failure was 6.8% (3.4% early; 3.4% late), and peri\u2010implantitis incidence was 7.6%. In multivariable analyses, self\u2010reported penicillin allergy (OR\u2009=\u20097.9; 95% CI: 2.7\u201323.7) and anterior implant location (OR\u2009=\u20095.4; 95% CI: 2.0\u201314.0) were associated with higher odds of early implant failure, whereas antihypertensive medication use (OR\u2009=\u20090.26; 95% CI:0.08\u20130.91) was associated with lower odds (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Late implant failure was associated with hypertension (HR\u2009=\u20092.1; 95% CI: 1.3\u20133.3), previously grafted sites (HR\u2009=\u20091.4; 95% CI:1.0\u20131.9), and bone\u2010level implants (HR\u2009=\u200910.4; 95% CI: 5.5\u201319.5). In cluster\u2010robust sensitivity analysis, the association between bone\u2010level implants and late implant failure was attenuated but remained significant (HR\u2009=\u20093.38; 95% CI: 1.96\u20135.84). Peri\u2010implantitis was associated with periodontitis (HR\u2009=\u20093.6; 95% CI: 1.89\u20136.97), excess cement (HR\u2009=\u20092.7; 95% CI: 1.25\u20135.88), and PLCBL (HR\u2009=\u20092.1; 95% CI: 1.09\u20134.13) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Robustness analyses generally supported the direction of the identified associations, although some effect estimates were attenuated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Implant failure and peri\u2010implantitis are associated with distinct, potentially modifiable patient\u2010 and treatment\u2010related factors. Recognition of these factors may help identify patients and implants at increased risk of adverse outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.70181","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:42:32Z","timestamp":1790397752000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk Factors for Implant Failure and Peri\u2010Implantitis: A Retrospective Cohort Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0111-2309","authenticated-orcid":false,"given":"Nathalia","family":"Vilela","sequence":"first","affiliation":[{"name":"Department of Periodontology, College of Dentistry University of Florida  Gainesville USA"},{"name":"Department of Stomatology, Division of Periodontology, School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5971-134X","authenticated-orcid":false,"given":"Bruno C. V.","family":"Gurgel","sequence":"additional","affiliation":[{"name":"Department of Dentistry Federal University of Rio Grande do Norte  Natal Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lio D. P.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Dental Research Division Guarulhos University  Guarulhos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4181-3975","authenticated-orcid":false,"given":"Claudio M.","family":"Pannuti","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Division of Periodontology, School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8872-5943","authenticated-orcid":false,"given":"Poliana M.","family":"Duarte","sequence":"additional","affiliation":[{"name":"Department of Periodontology, College of Dentistry University of Florida  Gainesville 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