{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:00:49Z","timestamp":1790312449978,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Implant survival in the esthetic zone is often reported as an overall outcome, although factors associated with failure may vary across different phases of treatment. This study evaluated real\u2010world implant survival in the anterior maxilla and examined whether risk patterns differ between early and late failure phases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This retrospective study used electronic health record data from a nationwide dental network. A total of 14,079 implants placed in 8234 patients between 2014 and 2023 were analyzed. Implant failure was defined as removal or spontaneous exfoliation. Survival was assessed using Kaplan\u2013Meier analysis and Cox proportional hazards models with patient\u2010level clustering. A 6\u2010month timing\u2010specific approach distinguished early from late failures, with restoration modeled as a time\u2010varying covariate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During a mean follow\u2010up of 6.0\u2009\u00b1\u20092.9\u2009years, 358 implants failed, yielding a failure rate of 2.5% and an incidence rate of 0.43 failures per 100 implant\u2010years. Early failures accounted for 43.6% of failures. Short implant length (\u2264\u20098\u2009mm) was associated with failure across all phases, based on a small subgroup (54 implants; overall HR 5.15, 95% CI 2.40\u201311.02;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Immediate restoration was associated with early failure (HR 1.91, 95% CI 1.28\u20132.85;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). Smoking was associated with late failure (HR 1.81, 95% CI 1.29\u20132.54;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Implant survival in the anterior maxilla was high, but failure risk differed by phase. Short implants (\u2264\u20098\u2009mm) were associated with failure across all phases, while immediate restoration was associated with early failure and smoking with late failure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.70183","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:44:41Z","timestamp":1790311481000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Implant Survival in the Esthetic Zone: Uncovering Timing\u2010Specific Risk Patterns in a Large Cohort"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9238-7940","authenticated-orcid":false,"given":"Doron","family":"Haim","sequence":"first","affiliation":[{"name":"Department of Health Systems Management, Faculty of Health Sciences Ariel University  Ariel Israel"},{"name":"Research and Innovation Department Maccabi\u2010Dent  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7493-5026","authenticated-orcid":false,"given":"Hadar","family":"Better","sequence":"additional","affiliation":[{"name":"Research and Innovation Department Maccabi\u2010Dent  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Meinster","sequence":"additional","affiliation":[{"name":"Research and Innovation Department Maccabi\u2010Dent  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9821-0560","authenticated-orcid":false,"given":"Shai","family":"Cahana","sequence":"additional","affiliation":[{"name":"Research and Innovation Department Maccabi\u2010Dent  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5611-4934","authenticated-orcid":false,"given":"Elazar","family":"Librush","sequence":"additional","affiliation":[{"name":"Research and Innovation Department Maccabi\u2010Dent  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8709-3112","authenticated-orcid":false,"given":"Anat","family":"Reiner\u2010Benaim","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Biostatistics and Community Health Sciences, School of Public Health, Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Be'er\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0540-5699","authenticated-orcid":false,"given":"Liat","family":"Barness\u2010Hadar","sequence":"additional","affiliation":[{"name":"Research and Innovation Department Maccabi\u2010Dent  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9176-4978","authenticated-orcid":false,"given":"Gavriel","family":"Chaushu","sequence":"additional","affiliation":[{"name":"Research and Innovation Department Maccabi\u2010Dent  Tel Aviv Israel"},{"name":"Department of Oral and Maxillofacial Surgery Rabin Medical Center  Petah Tiqwa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1875-7402","authenticated-orcid":false,"given":"Thabet","family":"Asbi","sequence":"additional","affiliation":[{"name":"Research and Innovation Department Maccabi\u2010Dent  Tel Aviv Israel"},{"name":"Department of Periodontology Rambam Health Care Campus  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.SDENTJ.2024.06.010"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/HEALTHCARE13121356"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.7759\/CUREUS.65506"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.70162"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.70173"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/CRE2.70096"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PROSDENT.2019.05.013"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/FDMED.2025.1563641\/FULL"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/152420"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/JOOR.12157;PAGE:STRING:ARTICLE\/CHAPTER"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2015.03.003"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/IJERPH17113931"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/NJMS.NJMS_75_16"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/J.0909\u20108836..T01\u20106\u2010.X"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/CID.12994"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.70142"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2019.03.008"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.7759\/CUREUS.55360"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.7759\/CUREUS.30455"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201090142\u20105"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12903\u2010019\u20100900\u20108"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/S12561\u2010016\u20109157\u20109"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/S40729\u2010020\u201000276\u2010W"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpor.2010.10.004"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/DIAGNOSTICS14151697"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.11607\/JOMI.9769"}],"container-title":["Clinical 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