{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T04:41:34Z","timestamp":1792557694984,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE023348"],"award-info":[{"award-number":["DE023348"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE033281"],"award-info":[{"award-number":["DE033281"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE030536"],"award-info":[{"award-number":["DE030536"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Medication\u2010related osteonecrosis of the jaw (MRONJ) is a debilitating condition associated with antiresorptive agents (ARAs) and can occur around well\u2010osseointegrated dental implants. Although implant presence\u2013triggered osteonecrosis (IPTO) has been primarily linked to bacteria\u2010related peri\u2010implantitis, whether occlusal trauma contributes to IPTO remains unclear. Therefore, this study developed a novel premature occlusal contact (POC) mouse implant model to evaluate the effect of occlusal trauma on MRONJ development around osseointegrated implants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      Eighteen mice underwent bilateral maxillary first molar extraction followed by immediate implant placement. After a 3\u2010week healing period to allow osseointegration, mice were randomized to receive intravenous zoledronic acid (ZOL, 125\u2009\u03bcg\/kg) or saline vehicle (Veh) twice weekly (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099 per group). One week later, POC was induced in a split\u2010mouth design by applying composite resin to one implant, whereas the contralateral implant served as a control. After 5\u2009weeks of occlusal loading, mice were euthanized for \u03bcCT and histological analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\u03bcCT analysis revealed that POC reduced radiographic bone\u2010to\u2010implant contact (rBIC) in both Veh\u2010 and ZOL\u2010treated mice. POC significantly increased empty lacunae around the implant neck in Veh\u2010treated mice, whereas in ZOL\u2010treated mice, POC induced extensive circumferential bone necrosis around the implant, accompanied by increased macrophage infiltration. No significant differences in peptidoglycan (PGN)\u2010positive signals were observed among the experimental groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that POC contributes to peri\u2010implant osteonecrosis under ZOL treatment, supporting occlusal trauma as an important local factor in MRONJ development around osseointegrated dental implants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.70191","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T04:22:08Z","timestamp":1792556528000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Premature Occlusal Contacts Induce\n                    <scp>MRONJ<\/scp>\n                    in Osseointegrated Dental Implants: An Experimental In\u00a0Vivo Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9524-3835","authenticated-orcid":false,"given":"Eun\u2010Bin","family":"Bae","sequence":"first","affiliation":[{"name":"The Shapiro Family Laboratory of Viral Oncology and Aging Research UCLA School of Dentistry  Los Angeles California USA"},{"name":"Section of Restorative Dentistry UCLA School of Dentistry  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9461-6950","authenticated-orcid":false,"given":"Ahana","family":"Goswami","sequence":"additional","affiliation":[{"name":"The Shapiro Family Laboratory of Viral Oncology and Aging Research UCLA School of Dentistry  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8160-3502","authenticated-orcid":false,"given":"Jun","family":"Yaung","sequence":"additional","affiliation":[{"name":"The Shapiro Family Laboratory of Viral Oncology and Aging Research UCLA School of Dentistry  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0244-1436","authenticated-orcid":false,"given":"Soo Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"The Shapiro Family Laboratory of Viral Oncology and Aging Research UCLA School of Dentistry  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9743-3643","authenticated-orcid":false,"given":"Sherry S.","family":"Baik","sequence":"additional","affiliation":[{"name":"The Shapiro Family Laboratory of Viral Oncology and Aging Research UCLA School of Dentistry  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4266-3306","authenticated-orcid":false,"given":"Kaylyn A.","family":"Yu","sequence":"additional","affiliation":[{"name":"The Shapiro Family Laboratory of Viral Oncology and Aging Research UCLA School of Dentistry  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5729-5127","authenticated-orcid":false,"given":"Chan","family":"Park","sequence":"additional","affiliation":[{"name":"The Shapiro Family Laboratory of Viral Oncology and Aging Research UCLA School of Dentistry  Los Angeles California USA"},{"name":"Department of Prosthodontics, School of Dentistry Chonnam National University  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7578-1989","authenticated-orcid":false,"given":"Jung\u2010Bo","family":"Huh","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Dental Research Institute, Dental and Life Sciences Institute, Education and Research Team for Life Science on Dentistry, School of Dentistry Pusan National University  Yangsan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9423-438X","authenticated-orcid":false,"given":"Jae\u2010Young","family":"Kim","sequence":"additional","affiliation":[{"name":"The Shapiro Family Laboratory of Viral Oncology and Aging Research UCLA School of Dentistry  Los Angeles California USA"},{"name":"Department of Oral and Maxillofacial Surgery Yonsei University Gangnam Severance Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9123-7737","authenticated-orcid":false,"given":"Christine Y.","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, School of Dentistry University of Washington  Seattle Washington 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