{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T04:42:49Z","timestamp":1792557769491,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the diagnostic accuracy of host\u2010derived and microbiological biomarkers, alone and in combination with clinical parameters, for the detection of peri\u2010implant bone loss (BL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A university\u2010based cohort of subjects with dental implants was examined at baseline and after a mean follow\u2010up of 3.9\u2009years. Peri\u2010implant BL served as the reference standard, defined as &gt;\u20091\u2009mm between baseline and follow\u2010up radiographs; implants with &lt;\u20090.5\u2009mm BL served as controls. At follow\u2010up, peri\u2010implant crevicular fluid and submarginal\u2010microbiological samples were collected. Bone metabolism and inflammatory biomarkers were quantified using Luminex technology. Bacterial loads were quantified by qPCR. Associations of biomarkers with BL were evaluated using multilevel logistic regression models. Diagnostic accuracy was assessed using ROC curves, with AUC, sensitivity, specificity, and predictive values reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010one subjects with 273 implants were included. Twenty\u2010eight exhibited peri\u2010implant\u2010BL &gt;\u20091.0\u2009mm over the follow\u2010up period. Increased levels of IL\u20101\u03b2,\n                      <jats:italic>T. denticola, Fusobacterium<\/jats:italic>\n                      spp., and\n                      <jats:italic>T. forsythia<\/jats:italic>\n                      were associated with BL in unadjusted analyses. However, these associations were no longer statistically significant after adjustment for clinical parameters. Individual biomarkers demonstrated limited diagnostic accuracy (maximum AUC\u2009=\u20090.68). In contrast, biomarker combinations with clinical parameters exhibited excellent discriminative performance (AUC &gt;\u20090.95). The combination of IL\u20101\u03b2 and BoP\u2010or\u2010PPD achieved the highest accuracy (AUC\u2009=\u20090.97).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While individual biomarkers showed limited diagnostic utility, combining multiple predictors significantly improved the ability to detect peri\u2010implant BL. Combining IL\u20101\u03b2 with either BoP or PPD significantly outperformed individual clinical measures but did not outperform the combination of clinical parameters, highlighting the potential of integrated biomarker and clinical parameter approaches as screening tools for detecting BL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.70193","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T04:35:12Z","timestamp":1792557312000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combined Host\u2010Derived and Microbiological Biomarkers for the Detection of Peri\u2010Implant Bone Loss: A Diagnostic Accuracy Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9841-9405","authenticated-orcid":false,"given":"Marion","family":"Arce","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry, School of Dentistry University of Chile  Santiago Chile"},{"name":"ETEP Research Group, School of Dentistry Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Lima","sequence":"additional","affiliation":[{"name":"ETEP Research Group, School of Dentistry Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3376-5232","authenticated-orcid":false,"given":"Leire","family":"Virto","sequence":"additional","affiliation":[{"name":"ETEP Research Group, School of Dentistry Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5199-8067","authenticated-orcid":false,"given":"Juan Daniel","family":"Gamonal","sequence":"additional","affiliation":[{"name":"ETEP Research Group, School of Dentistry Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo","family":"Banaco","sequence":"additional","affiliation":[{"name":"ETEP Research Group, School of Dentistry Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5646-083X","authenticated-orcid":false,"given":"Mario","family":"Romandini","sequence":"additional","affiliation":[{"name":"Department of Implant Dentistry, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6293-5755","authenticated-orcid":false,"given":"Mariano","family":"Sanz","sequence":"additional","affiliation":[{"name":"ETEP Research Group, School of Dentistry Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics9040214"},{"issue":"3","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","DOI":"10.3390\/medsci13030187","article-title":"Transcriptomic and Metagenomic Biomarkers in Peri\u2010Implantitis: A Systematic Review, Diagnostic Meta\u2010Analysis, and Functional Meta\u2010Synthesis","volume":"13","author":"Ardila C. 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