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cluster","volume":"177","author":"Stojiljkovic","year":"1995","journal-title":"J Bacteriol"},{"key":"10.1111\/cmi.12088-BIB0074|cmi12088-cit-0074","doi-asserted-by":"crossref","first-page":"33897","DOI":"10.1074\/jbc.C700181200","article-title":"Injection of flagellin into the host cell cytosol by Salmonella enterica serotype Typhimurium","volume":"282","author":"Sun","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1111\/cmi.12088-BIB0075|cmi12088-cit-0075","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1084\/jem.20071239","article-title":"Immune recognition of Pseudomonas aeruginosa mediated by the IPAF\/NLRC4 inflammasome","volume":"204","author":"Sutterwala","year":"2007","journal-title":"J Exp Med"},{"key":"10.1111\/cmi.12088-BIB0076|cmi12088-cit-0076","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.it.2011.01.003","article-title":"Inflammasome activation and IL-1beta and IL-18 processing during 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