{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T13:36:18Z","timestamp":1780925778177,"version":"3.54.1"},"reference-count":45,"publisher":"Hindawi Limited","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":456,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Microbiol"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1111\/cmi.12305","type":"journal-article","created":{"date-parts":[[2014,4,29]],"date-time":"2014-04-29T12:44:47Z","timestamp":1398775487000},"page":"1441-1455","source":"Crossref","is-referenced-by-count":16,"title":["The focal complex of epithelial cells provides a signalling platform for interleukin-8 induction in response to bacterial pathogens"],"prefix":"10.1155","volume":"16","author":[{"given":"Tyson P.","family":"Eucker","sequence":"first","affiliation":[{"name":"School of Molecular Biosciences; College of Veterinary Medicine; Washington State University; Pullman WA 99164-7520 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derrick R.","family":"Samuelson","sequence":"additional","affiliation":[{"name":"School of Molecular Biosciences; College of Veterinary Medicine; Washington State University; Pullman WA 99164-7520 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Hunzicker-Dunn","sequence":"additional","affiliation":[{"name":"School of Molecular Biosciences; College of Veterinary Medicine; Washington State University; Pullman WA 99164-7520 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Konkel","sequence":"additional","affiliation":[{"name":"School of Molecular Biosciences; College of Veterinary Medicine; Washington State University; Pullman WA 99164-7520 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","published-online":{"date-parts":[[2014,6,2]]},"reference":[{"key":"10.1111\/cmi.12305-BIB0001|cmi12305-cit-0001","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1146\/annurev.immunol.15.1.675","article-title":"Human chemokines: an update","volume":"15","author":"Baggiolini","year":"1997","journal-title":"Annu Rev Immunol"},{"key":"10.1111\/cmi.12305-BIB0002|cmi12305-cit-0002","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1042\/bst0320438","article-title":"Integrin regulation of epidermal growth factor (EGF) receptor and of EGF-dependent responses","volume":"32","author":"Cabodi","year":"2004","journal-title":"Biochem Soc Trans"},{"key":"10.1111\/cmi.12305-BIB0003|cmi12305-cit-0003","doi-asserted-by":"crossref","first-page":"26329","DOI":"10.1074\/jbc.271.42.26329","article-title":"Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase","volume":"271","author":"Chen","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1111\/cmi.12305-BIB0004|cmi12305-cit-0004","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/nrmicro1095","article-title":"Helicobacter pylori VacA, a paradigm for toxin multifunctionality","volume":"3","author":"Cover","year":"2005","journal-title":"Nat Rev Microbiol"},{"key":"10.1111\/cmi.12305-BIB0005|cmi12305-cit-0005","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1462-5822.2011.01714.x","article-title":"The cooperative action of bacterial fibronectin-binding proteins and secreted proteins promote maximal Campylobacter jejuni invasion of host cells by stimulating membrane ruffling","volume":"14","author":"Eucker","year":"2012","journal-title":"Cell Microbiol"},{"key":"10.1111\/cmi.12305-BIB0006|cmi12305-cit-0006","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1128\/IAI.01266-08","article-title":"Examination of Campylobacter jejuni putative adhesins leads to the identification of a new protein, designated FlpA, required for chicken colonization","volume":"77","author":"Flanagan","year":"2009","journal-title":"Infect Immun"},{"key":"10.1111\/cmi.12305-BIB0007|cmi12305-cit-0007","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1128\/IAI.70.2.558-568.2002","article-title":"Porins from Salmonella enterica serovar Typhimurium activate the transcription factors activating protein 1 and NF-kappaB through the Raf-1-mitogen-activated protein kinase cascade","volume":"70","author":"Galdiero","year":"2002","journal-title":"Infect Immun"},{"key":"10.1111\/cmi.12305-BIB0008|cmi12305-cit-0008","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1126\/science.285.5430.1028","article-title":"Integrin signaling","volume":"285","author":"Giancotti","year":"1999","journal-title":"Science"},{"key":"10.1111\/cmi.12305-BIB0009|cmi12305-cit-0009","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/B978-0-12-386041-5.00005-4","article-title":"Focal adhesion kinase: exploring Fak structure to gain insight into function","volume":"288","author":"Hall","year":"2011","journal-title":"Int Rev Cell Mol Biol"},{"key":"10.1111\/cmi.12305-BIB0010|cmi12305-cit-0010","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1574-6976.2010.00243.x","article-title":"Fibronectin: a multidomain host adhesin targeted by bacterial fibronectin-binding proteins","volume":"35","author":"Henderson","year":"2011","journal-title":"FEMS Microbiol Rev"},{"key":"10.1111\/cmi.12305-BIB0011|cmi12305-cit-0011","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1189\/jlb.72.5.847","article-title":"Multiple control of interleukin-8 gene expression","volume":"72","author":"Hoffmann","year":"2002","journal-title":"J Leukoc Biol"},{"key":"10.1111\/cmi.12305-BIB0012|cmi12305-cit-0012","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","article-title":"Integrins: bidirectional, allosteric signaling machines","volume":"110","author":"Hynes","year":"2002","journal-title":"Cell"},{"key":"10.1111\/cmi.12305-BIB0013|cmi12305-cit-0013","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/S1097-2765(03)00406-4","article-title":"Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis","volume":"12","author":"Ishibe","year":"2003","journal-title":"Mol Cell"},{"key":"10.1111\/cmi.12305-BIB0014|cmi12305-cit-0014","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.molcel.2004.10.006","article-title":"Paxillin serves as an ERK-regulated scaffold for coordinating FAK and Rac activation in epithelial morphogenesis","volume":"16","author":"Ishibe","year":"2004","journal-title":"Mol Cell"},{"key":"10.1111\/cmi.12305-BIB0015|cmi12305-cit-0015","doi-asserted-by":"crossref","first-page":"4945","DOI":"10.1128\/IAI.60.11.4945-4949.1992","article-title":"Altered synthetic response of Campylobacter jejuni to cocultivation with human epithelial cells is associated with enhanced internalization","volume":"60","author":"Konkel","year":"1992","journal-title":"Infect Immun"},{"key":"10.1111\/cmi.12305-BIB0016|cmi12305-cit-0016","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1093\/infdis\/168.4.948","article-title":"Kinetic and antigenic characterization of altered protein synthesis by Campylobacter jejuni during cultivation with human epithelial cells","volume":"168","author":"Konkel","year":"1993","journal-title":"J Infect Dis"},{"key":"10.1111\/cmi.12305-BIB0017|cmi12305-cit-0017","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1046\/j.1365-2958.1997.4031771.x","article-title":"Identification and molecular cloning of a gene encoding a fibronectin-binding protein (CadF) from Campylobacter jejuni","volume":"24","author":"Konkel","year":"1997","journal-title":"Mol Microbiol"},{"key":"10.1111\/cmi.12305-BIB0018|cmi12305-cit-0018","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1128\/JB.00969-09","article-title":"Campylobacter jejuni FlpA binds fibronectin and is required for maximal host cell adherence","volume":"192","author":"Konkel","year":"2010","journal-title":"J Bacteriol"},{"key":"10.1111\/cmi.12305-BIB0019|cmi12305-cit-0019","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nature06187","article-title":"Helicobacter exploits integrin for type IV secretion and kinase activation","volume":"449","author":"Kwok","year":"2007","journal-title":"Nature"},{"key":"10.1111\/cmi.12305-BIB0020|cmi12305-cit-0020","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1186\/1471-2180-10-329","article-title":"The Vibrio parahaemolyticus Type III Secretion Systems manipulate host cell MAPK for critical steps in pathogenesis","volume":"10","author":"Matlawska-Wasowska","year":"2010","journal-title":"BMC Microbiol"},{"key":"10.1111\/cmi.12305-BIB0021|cmi12305-cit-0021","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.ceb.2006.08.011","article-title":"Integrin-regulated FAK-Src signaling in normal and cancer cells","volume":"18","author":"Mitra","year":"2006","journal-title":"Curr Opin Cell Biol"},{"key":"10.1111\/cmi.12305-BIB0022|cmi12305-cit-0022","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nrm1549","article-title":"Focal adhesion kinase: in command and control of cell motility","volume":"6","author":"Mitra","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1111\/cmi.12305-BIB0023|cmi12305-cit-0023","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1136\/gut.49.1.18","article-title":"Helicobacter pylori induced transactivation of SRE and AP-1 through the ERK signalling pathway in gastric cancer cells","volume":"49","author":"Mitsuno","year":"2001","journal-title":"Gut"},{"key":"10.1111\/cmi.12305-BIB0024|cmi12305-cit-0024","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1099\/mic.0.25820-0","article-title":"Maximal adherence and invasion of INT 407 cells by Campylobacter jejuni requires the CadF outer-membrane protein and microfilament reorganization","volume":"149","author":"Monteville","year":"2003","journal-title":"Microbiology"},{"key":"10.1111\/cmi.12305-BIB0025|cmi12305-cit-0025","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1242\/jcs.114.9.1609","article-title":"KSR: a MAPK scaffold of the Ras pathway?","volume":"114","author":"Morrison","year":"2001","journal-title":"J Cell Sci"},{"key":"10.1111\/cmi.12305-BIB0026|cmi12305-cit-0026","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.2741\/1239","article-title":"Regulation of endothelial cell function BY FAK and PYK2","volume":"9","author":"Orr","year":"2004","journal-title":"Front Biosci"},{"key":"10.1111\/cmi.12305-BIB0027|cmi12305-cit-0027","doi-asserted-by":"crossref","first-page":"7906","DOI":"10.1038\/sj.onc.1208160","article-title":"Src family kinases, key regulators of signal transduction","volume":"23","author":"Parsons","year":"2004","journal-title":"Oncogene"},{"key":"10.1111\/cmi.12305-BIB0028|cmi12305-cit-0028","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1038\/sj.onc.1210422","article-title":"Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer","volume":"26","author":"Roberts","year":"2007","journal-title":"Oncogene"},{"key":"10.1111\/cmi.12305-BIB0029|cmi12305-cit-0029","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/43474","article-title":"NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling","volume":"401","author":"Romashkova","year":"1999","journal-title":"Nature"},{"key":"10.1111\/cmi.12305-BIB0030|cmi12305-cit-0030","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1101\/gad.962902","article-title":"KSR is a scaffold required for activation of the ERK\/MAPK module","volume":"16","author":"Roy","year":"2002","journal-title":"Genes Dev"},{"key":"10.1111\/cmi.12305-BIB0031|cmi12305-cit-0031","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1478-811X-11-79","article-title":"The Campylobacter jejuni CiaD effector protein activates MAP kinase signaling pathways and is required for the development of disease","volume":"11","author":"Samuelson","year":"2013","journal-title":"Cell Commun Signal"},{"key":"10.1111\/cmi.12305-BIB0032|cmi12305-cit-0032","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1128\/IAI.67.3.1471-1480.1999","article-title":"Interleukin-8 controls bacterial transepithelial translocation at the cost of epithelial destruction in experimental shigellosis","volume":"67","author":"Sansonetti","year":"1999","journal-title":"Infect Immun"},{"key":"10.1111\/cmi.12305-BIB0033|cmi12305-cit-0033","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1128\/MCB.19.4.2435","article-title":"Mitogen-activated protein kinases: specific messages from ubiquitous messengers","volume":"19","author":"Schaeffer","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1111\/cmi.12305-BIB0034|cmi12305-cit-0034","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1128\/MCB.15.5.2635","article-title":"pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk","volume":"15","author":"Schaller","year":"1995","journal-title":"Mol Cell Biol"},{"key":"10.1111\/cmi.12305-BIB0035|cmi12305-cit-0035","doi-asserted-by":"crossref","first-page":"E65-8","DOI":"10.1038\/ncb0402-e65","article-title":"Networks and crosstalk: integrin signalling spreads","volume":"4","author":"Schwartz","year":"2002","journal-title":"Nat Cell Biol"},{"key":"10.1111\/cmi.12305-BIB0036|cmi12305-cit-0036","doi-asserted-by":"crossref","first-page":"28787","DOI":"10.1074\/jbc.M110.134064","article-title":"Paxillin regulates androgen- and epidermal growth factor-induced MAPK signaling and cell proliferation in prostate cancer cells","volume":"285","author":"Sen","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1111\/cmi.12305-BIB0037|cmi12305-cit-0037","doi-asserted-by":"crossref","first-page":"4698","DOI":"10.1091\/mbc.E06-06-0492","article-title":"Invasion of host cells by Salmonella typhimurium requires focal adhesion kinase and p130Cas","volume":"17","author":"Shi","year":"2006","journal-title":"Mol Biol Cell"},{"key":"10.1111\/cmi.12305-BIB0038|cmi12305-cit-0038","doi-asserted-by":"crossref","first-page":"G601","DOI":"10.1152\/ajpgi.00375.2010","article-title":"Paxillin is a novel cellular target for converging Helicobacter pylori-induced cellular signaling","volume":"301","author":"Tabassam","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1111\/cmi.12305-BIB0039|cmi12305-cit-0039","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1172\/JCI11830","article-title":"NF-kappaB: a key role in inflammatory diseases","volume":"107","author":"Tak","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1111\/cmi.12305-BIB0040|cmi12305-cit-0040","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1128\/IAI.73.3.1523-1531.2005","article-title":"Helicobacter pylori induces interleukin-8 secretion by Toll-like receptor 2- and Toll-like receptor 5-dependent and -independent pathways","volume":"73","author":"Torok","year":"2005","journal-title":"Infect Immun"},{"key":"10.1111\/cmi.12305-BIB0041|cmi12305-cit-0041","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cyto.2004.03.010","article-title":"Interleukin-8 production by THP-1 cells stimulated by Salmonella enterica serovar Typhimurium porins is mediated by AP-1, NF-kappaB and MAPK pathways","volume":"27","author":"Vitiello","year":"2004","journal-title":"Cytokine"},{"key":"10.1111\/cmi.12305-BIB0042|cmi12305-cit-0042","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/j.1462-5822.2004.00498.x","article-title":"Signal transduction in Campylobacter jejuni-induced cytokine production","volume":"7","author":"Watson","year":"2005","journal-title":"Cell Microbiol"},{"key":"10.1111\/cmi.12305-BIB0043|cmi12305-cit-0043","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.chom.2010.06.003","article-title":"The blessings and curses of intestinal inflammation","volume":"8","author":"Winter","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1111\/cmi.12305-BIB0044|cmi12305-cit-0044","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.bbamcr.2004.04.007","article-title":"Focal adhesion regulation of cell behavior","volume":"1692","author":"Wozniak","year":"2004","journal-title":"Biochim Biophys Acta"},{"key":"10.1111\/cmi.12305-BIB0045|cmi12305-cit-0045","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1242\/jcs.030478","article-title":"FAK engages multiple pathways to maintain survival of fibroblasts and epithelia: differential roles for paxillin and p130Cas","volume":"122","author":"Zouq","year":"2009","journal-title":"J Cell Sci"}],"container-title":["Cellular Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcmi.12305","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/cmi.12305\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T13:49:10Z","timestamp":1689169750000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cmi.12305"}},"subtitle":["Pathogen-mediated IL-8 induction"],"short-title":[],"issued":{"date-parts":[[2014,6,2]]},"references-count":45,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"URL":"https:\/\/doi.org\/10.1111\/cmi.12305","relation":{},"ISSN":["1462-5814"],"issn-type":[{"value":"1462-5814","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6,2]]}}}