{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:23:59Z","timestamp":1792185839838,"version":"4.4.0"},"reference-count":78,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":280,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R00 TW008042"],"award-info":[{"award-number":["R00 TW008042"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI097312"],"award-info":[{"award-number":["R01 AI097312"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 GM087828"],"award-info":[{"award-number":["R01 GM087828"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 AI007046"],"award-info":[{"award-number":["T32 AI007046"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 GM008136"],"award-info":[{"award-number":["T32 GM008136"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001309","name":"Research Corporation for the Advancement of Science","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001309","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Microbiol"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1111\/cmi.12389","type":"journal-article","created":{"date-parts":[[2014,10,27]],"date-time":"2014-10-27T05:54:38Z","timestamp":1414389278000},"page":"648-665","source":"Crossref","is-referenced-by-count":34,"title":["Opa+\n                    <i>N<\/i>\n                    <i>eisseria gonorrhoeae<\/i>\n                    exhibits reduced survival in human neutrophils via Src family kinase-mediated bacterial trafficking into mature phagolysosomes"],"prefix":"10.1155","volume":"17","author":[{"given":"M. Brittany","family":"Johnson","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology, and Cancer Biology; University of Virginia; Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise M.","family":"Ball","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Cancer Biology; University of Virginia; Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylene P.","family":"Daily","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Cancer Biology; University of Virginia; Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer N.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Chemistry; University of Virginia; Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Columbus","sequence":"additional","affiliation":[{"name":"Department of Chemistry; University of Virginia; Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison K.","family":"Criss","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Cancer Biology; University of Virginia; Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,25]]},"reference":[{"key":"10.1111\/cmi.12389-BIB0001|cmi12389-cit-0001","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1139\/y04-123","article-title":"Neutrophil primary granule release and maximal superoxide generation depend on Rac2 in a common signalling pathway","volume":"83","author":"Abdel-Latif","year":"2005","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1111\/cmi.12389-BIB0002|cmi12389-cit-0002","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.1128\/IAI.68.8.4827-4830.2000","article-title":"Lipoarabinomannans activate the protein tyrosine kinase Hck in human neutrophils","volume":"68","author":"Astarie-Dequeker","year":"2000","journal-title":"Infect Immun"},{"key":"10.1111\/cmi.12389-BIB0003|cmi12389-cit-0003","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1128\/JB.00171-13","article-title":"Constitutively Opa-expressing and opa-deficient Neisseria gonorrhoeae strains differentially stimulate and survive exposure to human neutrophils","volume":"195","author":"Ball","year":"2013","journal-title":"J Bacteriol"},{"key":"10.1111\/cmi.12389-BIB0004|cmi12389-cit-0004","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1111\/j.1365-2958.1991.tb00813.x","article-title":"The opacity proteins of Neisseria gonorrhoeae strain MS11 are encoded by a family of 11 complete genes","volume":"5","author":"Bhat","year":"1991","journal-title":"Mol Microbiol"},{"key":"10.1111\/cmi.12389-BIB0005|cmi12389-cit-0005","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.immuni.2010.11.011","article-title":"Neutrophils, from marrow to microbes","volume":"33","author":"Borregaard","year":"2010","journal-title":"Immunity"},{"key":"10.1111\/cmi.12389-BIB0006|cmi12389-cit-0006","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.it.2007.06.002","article-title":"Neutrophil granules: a library of innate immunity proteins","volume":"28","author":"Borregaard","year":"2007","journal-title":"Trends Immunol"},{"key":"10.1111\/cmi.12389-BIB0007|cmi12389-cit-0007","doi-asserted-by":"crossref","first-page":"9584","DOI":"10.1073\/pnas.95.16.9584","article-title":"CD66 receptor specificity exhibited by neisserial Opa variants is controlled by protein determinants in CD66 N-domains","volume":"95","author":"Bos","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/cmi.12389-BIB0008|cmi12389-cit-0008","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.abb.2012.03.020","article-title":"HemITAM signaling by CEACAM3, a human granulocyte receptor recognizing bacterial pathogens","volume":"524","author":"Buntru","year":"2012","journal-title":"Arch Biochem Biophys"},{"key":"10.1111\/cmi.12389-BIB0009|cmi12389-cit-0009","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1126\/science.1175653","article-title":"An alternative DNA structure is necessary for pilin antigenic variation in Neisseria gonorrhoeae","volume":"325","author":"Cahoon","year":"2009","journal-title":"Science"},{"key":"10.1111\/cmi.12389-BIB0010|cmi12389-cit-0010","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1128\/IAI.47.2.401-407.1985","article-title":"Anaerobiosis increases resistance of Neisseria gonorrhoeae to O2-independent antimicrobial proteins from human polymorphonuclear granulocytes","volume":"47","author":"Casey","year":"1985","journal-title":"Infect Immun"},{"key":"10.1111\/cmi.12389-BIB0011|cmi12389-cit-0011","doi-asserted-by":"crossref","first-page":"14851","DOI":"10.1073\/pnas.93.25.14851","article-title":"CGM1a antigen of neutrophils, a receptor of gonococcal opacity proteins","volume":"93","author":"Chen","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/cmi.12389-BIB0012|cmi12389-cit-0012","doi-asserted-by":"crossref","first-page":"17413","DOI":"10.1074\/jbc.M010609200","article-title":"The CGM1a (CEACAM3\/CD66d)-mediated phagocytic pathway of Neisseria gonorrhoeae expressing opacity proteins is also the pathway to cell death","volume":"276","author":"Chen","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1111\/cmi.12389-BIB0013|cmi12389-cit-0013","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1128\/IAI.00996-09","article-title":"Opacity proteins increase Neisseria gonorrhoeae fitness in the female genital tract due to a factor under ovarian control","volume":"78","author":"Cole","year":"2010","journal-title":"Infect Immun"},{"key":"10.1111\/cmi.12389-BIB0014|cmi12389-cit-0014","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1365-2958.1990.tb00610.x","article-title":"Characterization of the repertoire of hypervariable regions in the Protein II (opa) gene family of Neisseria gonorrhoeae","volume":"4","author":"Connell","year":"1990","journal-title":"Mol Microbiol"},{"key":"10.1111\/cmi.12389-BIB0015|cmi12389-cit-0015","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1128\/IAI.70.3.1591-1598.2002","article-title":"Lack of fusion of azurophil granules with phagosomes during phagocytosis of Mycobacterium smegmatis by human neutrophils is not actively controlled by the bacterium","volume":"70","author":"Cougoule","year":"2002","journal-title":"Infect Immun"},{"key":"10.1111\/cmi.12389-BIB0016|cmi12389-cit-0016","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1111\/j.1462-5822.2008.01205.x","article-title":"Neisseria gonorrhoeae suppresses the oxidative burst of human polymorphonuclear leukocytes","volume":"10","author":"Criss","year":"2008","journal-title":"Cell Microbiol"},{"key":"10.1111\/cmi.12389-BIB0017|cmi12389-cit-0017","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1111\/j.1462-5822.2009.01308.x","article-title":"Resistance of Neisseria gonorrhoeae to non-oxidative killing by adherent human polymorphonuclear leucocytes","volume":"11","author":"Criss","year":"2009","journal-title":"Cell Microbiol"},{"key":"10.1111\/cmi.12389-BIB0018|cmi12389-cit-0018","doi-asserted-by":"crossref","first-page":"5476","DOI":"10.1128\/jb.173.17.5476-5486.1991","article-title":"Physical map of the chromosome of Neisseria gonorrhoeae FA1090 with locations of genetic markers, including opa and pil genes","volume":"173","author":"Dempsey","year":"1991","journal-title":"J Bacteriol"},{"key":"10.1111\/cmi.12389-BIB0019|cmi12389-cit-0019","volume-title":"Biochemistry and Physiology of the Neutrophil","author":"Edwards","year":"2005"},{"key":"10.1111\/cmi.12389-BIB0020|cmi12389-cit-0020","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/S0960-9822(09)00454-0","article-title":"ARF and PITP restore GTP gamma S-stimulated protein secretion from cytosol-depleted HL60 cells by promoting PIP2 synthesis","volume":"6","author":"Fensome","year":"1996","journal-title":"Curr Biol"},{"key":"10.1111\/cmi.12389-BIB0021|cmi12389-cit-0021","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1128\/IAI.56.6.1574-1579.1988","article-title":"Gonococci possessing only certain P.II outer membrane proteins interact with human neutrophils","volume":"56","author":"Fischer","year":"1988","journal-title":"Infect Immun"},{"key":"10.1111\/cmi.12389-BIB0022|cmi12389-cit-0022","unstructured":"Fulcher , N.B. 2004 The role of Neisseria gonorrhoeae opacity proteins in host cell interactions and pathogenesis"},{"key":"10.1111\/cmi.12389-BIB0023|cmi12389-cit-0023","doi-asserted-by":"crossref","first-page":"3874","DOI":"10.4049\/jimmunol.178.6.3874","article-title":"The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine","volume":"178","author":"Fumagalli","year":"2007","journal-title":"J Immunol"},{"key":"10.1111\/cmi.12389-BIB0024|cmi12389-cit-0024","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nri1864","article-title":"CEACAM1: contact-dependent control of immunity","volume":"6","author":"Gray-Owen","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"10.1111\/cmi.12389-BIB0025|cmi12389-cit-0025","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1093\/emboj\/16.12.3435","article-title":"CD66 carcinoembryonic antigens mediate interactions between Opa-expressing Neisseria gonorrhoeae and human polymorphonuclear phagocytes","volume":"16","author":"Gray-Owen","year":"1997a","journal-title":"EMBO J"},{"key":"10.1111\/cmi.12389-BIB0026|cmi12389-cit-0026","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1046\/j.1365-2958.1997.6342006.x","article-title":"Differential Opa specificities for CD66 receptors influence tissue interactions and cellular response to Neisseria gonorrhoeae","volume":"26","author":"Gray-Owen","year":"1997b","journal-title":"Mol Microbiol"},{"key":"10.1111\/cmi.12389-BIB0027|cmi12389-cit-0027","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/emboj\/17.2.443","article-title":"CD66-mediated phagocytosis of Opa52 Neisseria gonorrhoeae requires a Src-like tyrosine kinase- and Rac1-dependent signalling pathway","volume":"17","author":"Hauck","year":"1998","journal-title":"EMBO J"},{"key":"10.1111\/cmi.12389-BIB0028|cmi12389-cit-0028","doi-asserted-by":"crossref","first-page":"5490","DOI":"10.1128\/IAI.67.10.5490-5494.1999","article-title":"Tyrosine phosphatase SHP-1 is involved in CD66-mediated phagocytosis of Opa52-expressing Neisseria gonorrhoeae","volume":"67","author":"Hauck","year":"1999","journal-title":"Infect Immun"},{"key":"10.1111\/cmi.12389-BIB0029|cmi12389-cit-0029","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2011.00123","article-title":"Experimental gonococcal infection in male volunteers: cumulative experience with Neisseria gonorrhoeae strains FA1090 and MS11mkC","volume":"2","author":"Hobbs","year":"2011","journal-title":"Front Microbiol"},{"key":"10.1111\/cmi.12389-BIB0030|cmi12389-cit-0030","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1128\/IAI.19.1.332-340.1978","article-title":"Studies on gonococcus infection. XIII. Occurrence of color\/opacity colonial variants in clinical cultures","volume":"19","author":"James","year":"1978","journal-title":"Infect Immun"},{"key":"10.1111\/cmi.12389-BIB0031|cmi12389-cit-0031","doi-asserted-by":"crossref","first-page":"5699","DOI":"10.1128\/IAI.67.11.5699-5708.1999","article-title":"Experimental gonococcal genital tract infection and opacity protein expression in estradiol-treated mice","volume":"67","author":"Jerse","year":"1999","journal-title":"Infect Immun"},{"key":"10.1111\/cmi.12389-BIB0032|cmi12389-cit-0032","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1111\/cmi.12117","article-title":"Neisseria gonorrhoeae phagosomes delay fusion with primary granules to enhance bacterial survival inside human neutrophils","volume":"15","author":"Johnson","year":"2013a","journal-title":"Cell Microbiol"},{"key":"10.1111\/cmi.12389-BIB0033|cmi12389-cit-0033","doi-asserted-by":"crossref","DOI":"10.3791\/50729","article-title":"Fluorescence microscopy methods for determining the viability of bacteria in association with mammalian cells","author":"Johnson","year":"2013b","journal-title":"J Vis Exp"},{"key":"10.1111\/cmi.12389-BIB0034|cmi12389-cit-0034","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1046\/j.1365-2958.2003.03749.x","article-title":"Mapping the binding domains on meningococcal Opa proteins for CEACAM1 and CEA receptors","volume":"50","author":"Jonge","year":"2003","journal-title":"Mol Microbiol"},{"key":"10.1111\/cmi.12389-BIB0035|cmi12389-cit-0035","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1128\/JB.85.6.1274-1279.1963","article-title":"Neisseria gonorrhoeae. I. virulence genetically linked to clonal variation","volume":"85","author":"Kellogg","year":"1963","journal-title":"J Bacteriol"},{"key":"10.1111\/cmi.12389-BIB0036|cmi12389-cit-0036","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/j.1460-2075.1993.tb05697.x","article-title":"Variable opacity (Opa) outer membrane proteins account for the cell tropisms displayed by Neisseria gonorrhoeae for human leukocytes and epithelial cells","volume":"12","author":"Kupsch","year":"1993","journal-title":"EMBO J"},{"key":"10.1111\/cmi.12389-BIB0037|cmi12389-cit-0037","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/1710-1492-2-3-98","article-title":"Mechanisms of degranulation in neutrophils","volume":"2","author":"Lacy","year":"2006","journal-title":"Allergy Asthma Clin Immunol"},{"key":"10.1111\/cmi.12389-BIB0038|cmi12389-cit-0038","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1046\/j.1365-2958.2003.03591.x","article-title":"Immunoreceptor tyrosine-based activation motif phosphorylation during engulfment of Neisseria gonorrhoeae by the neutrophil-restricted CEACAM3 (CD66d) receptor","volume":"49","author":"McCaw","year":"2003","journal-title":"Mol Microbiol"},{"key":"10.1111\/cmi.12389-BIB0039|cmi12389-cit-0039","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1128\/IAI.72.5.2742-2752.2004","article-title":"Engulfment of Neisseria gonorrhoeae: revealing distinct processes of bacterial entry by individual carcinoembryonic antigen-related cellular adhesion molecule family receptors","volume":"72","author":"McCaw","year":"2004","journal-title":"Infect Immun"},{"key":"10.1111\/cmi.12389-BIB0040|cmi12389-cit-0040","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1002\/j.1460-2075.1991.tb07649.x","article-title":"Phase variation of the opacity outer membrane protein controls invasion by Neisseria gonorrhoeae into human epithelial cells","volume":"10","author":"Makino","year":"1991","journal-title":"EMBO J"},{"key":"10.1111\/cmi.12389-BIB0041|cmi12389-cit-0041","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1128\/JB.180.5.1323-1330.1998","article-title":"Sequence diversity, predicted two-dimensional protein structure, and epitope mapping of neisserial Opa proteins","volume":"180","author":"Malorny","year":"1998","journal-title":"J Bacteriol"},{"key":"10.1111\/cmi.12389-BIB0042|cmi12389-cit-0042","doi-asserted-by":"crossref","first-page":"4321","DOI":"10.4049\/jimmunol.164.8.4321","article-title":"Kinase pathways in chemoattractant-induced degranulation of neutrophils: the role of p38 mitogen-activated protein kinase activated by Src family kinases","volume":"164","author":"Mocsai","year":"2000","journal-title":"J Immunol"},{"issue":"Part 2","key":"10.1111\/cmi.12389-BIB0043|cmi12389-cit-0043","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1042\/bj3090657","article-title":"The src-family protein-tyrosine kinase p59hck is located on the secretory granules in human neutrophils and translocates towards the phagosome during cell activation","volume":"309","author":"Mohn","year":"1995","journal-title":"Biochem J"},{"key":"10.1111\/cmi.12389-BIB0044|cmi12389-cit-0044","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/0092-8674(89)90577-1","article-title":"Phase variation of gonococcal protein II: regulation of gene expression by slipped-strand mispairing of a repetitive DNA sequence","volume":"56","author":"Murphy","year":"1989","journal-title":"Cell"},{"key":"10.1111\/cmi.12389-BIB0045|cmi12389-cit-0045","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.4049\/jimmunol.161.9.4983","article-title":"Fusion of azurophil granules with phagosomes and activation of the tyrosine kinase Hck are specifically inhibited during phagocytosis of mycobacteria by human neutrophils","volume":"161","author":"N'Diaye","year":"1998","journal-title":"J Immunol"},{"key":"10.1111\/cmi.12389-BIB0046|cmi12389-cit-0046","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.it.2009.07.011","article-title":"NETs: a new strategy for using old weapons","volume":"30","author":"Papayannopoulos","year":"2009","journal-title":"Trends Immunol"},{"key":"10.1111\/cmi.12389-BIB0047|cmi12389-cit-0047","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1128\/IAI.34.1.62-68.1981","article-title":"Degradation of gonococcal outer membrane proteins by human neutrophil lysosomal proteases","volume":"34","author":"Rest","year":"1981","journal-title":"Infect Immun"},{"issue":"Suppl.","key":"10.1111\/cmi.12389-BIB0048|cmi12389-cit-0048","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.1128\/CMR.2.Suppl.S83","article-title":"Interactions of Neisseria gonorrhoeae with human neutrophils","volume":"2","author":"Rest","year":"1989","journal-title":"Clin Microbiol Rev"},{"key":"10.1111\/cmi.12389-BIB0049|cmi12389-cit-0049","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1128\/IAI.36.2.737-744.1982","article-title":"Interactions of Neisseria gonorrhoeae with human neutrophils: effects of serum and gonococcal opacity on phagocyte killing and chemiluminescence","volume":"36","author":"Rest","year":"1982","journal-title":"Infect Immun"},{"key":"10.1111\/cmi.12389-BIB0050|cmi12389-cit-0050","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1128\/IAI.50.1.116-122.1985","article-title":"Stimulation of human leukocytes by protein II+ gonococci is mediated by lectin-like gonococcal components","volume":"50","author":"Rest","year":"1985","journal-title":"Infect Immun"},{"key":"10.1111\/cmi.12389-BIB0051|cmi12389-cit-0051","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1574-6976.2010.00260.x","article-title":"Opa proteins and CEACAMs: pathways of immune engagement for pathogenic Neisseria","volume":"35","author":"Sadarangani","year":"2011","journal-title":"FEMS Microbiol Rev"},{"key":"10.1111\/cmi.12389-BIB0052|cmi12389-cit-0052","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1111\/j.1462-5822.2007.00947.x","article-title":"The specific innate immune receptor CEACAM3 triggers neutrophil bactericidal activities via a Syk kinase-dependent pathway","volume":"9","author":"Sarantis","year":"2007","journal-title":"Cell Microbiol"},{"key":"10.1111\/cmi.12389-BIB0053|cmi12389-cit-0053","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1128\/IAI.05702-11","article-title":"Defining the roles of human carcinoembryonic antigen-related cellular adhesion molecules during neutrophil responses to Neisseria gonorrhoeae","volume":"80","author":"Sarantis","year":"2012","journal-title":"Infect Immun"},{"key":"10.1111\/cmi.12389-BIB0054|cmi12389-cit-0054","doi-asserted-by":"crossref","first-page":"5269","DOI":"10.1128\/IAI.73.8.5269-5272.2005","article-title":"Investigation of oxidative stress defenses of Neisseria gonorrhoeae by using a human polymorphonuclear leukocyte survival assay","volume":"73","author":"Seib","year":"2005","journal-title":"Infect Immun"},{"key":"10.1111\/cmi.12389-BIB0055|cmi12389-cit-0055","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.4049\/jimmunol.150.4.1535","article-title":"Control of exocytosis in early neutrophil activation","volume":"150","author":"Sengelov","year":"1993","journal-title":"J Immunol"},{"key":"10.1111\/cmi.12389-BIB0056|cmi12389-cit-0056","first-page":"155","article-title":"Cleavage of the protein III and major iron-regulated protein of Neisseria gonorrhoeae by lysosomal cathepsin G","volume":"133","author":"Shafer","year":"1987","journal-title":"J Gen Microbiol"},{"key":"10.1111\/cmi.12389-BIB0057|cmi12389-cit-0057","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1128\/IAI.54.1.184-188.1986","article-title":"Antigonococcal activity of human neutrophil cathepsin G","volume":"54","author":"Shafer","year":"1986","journal-title":"Infect Immun"},{"key":"10.1111\/cmi.12389-BIB0058|cmi12389-cit-0058","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1111\/j.1365-2958.1990.tb00706.x","article-title":"Molecular mechanism for the antigonococcal action of lysosomal cathepsin G","volume":"4","author":"Shafer","year":"1990","journal-title":"Mol Microbiol"},{"key":"10.1111\/cmi.12389-BIB0059|cmi12389-cit-0059","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1073\/pnas.95.4.1829","article-title":"Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance\/nodulation\/division efflux pump family","volume":"95","author":"Shafer","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/cmi.12389-BIB0060|cmi12389-cit-0060","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1128\/IAI.74.5.2965-2974.2006","article-title":"In vivo selection for Neisseria gonorrhoeae opacity protein expression in the absence of human carcinoembryonic antigen cell adhesion molecules","volume":"74","author":"Simms","year":"2006","journal-title":"Infect Immun"},{"key":"10.1111\/cmi.12389-BIB0061|cmi12389-cit-0061","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1128\/IAI.73.4.1971-1977.2005","article-title":"Interactions of Neisseria gonorrhoeae with adherent polymorphonuclear leukocytes","volume":"73","author":"Simons","year":"2005","journal-title":"Infect Immun"},{"key":"10.1111\/cmi.12389-BIB0062|cmi12389-cit-0062","doi-asserted-by":"crossref","first-page":"e1004341","DOI":"10.1371\/journal.ppat.1004341","article-title":"Global analysis of neutrophil responses to Neisseria gonorrhoeae reveals a self-propagating inflammatory program","volume":"10","author":"Sintsova","year":"2014","journal-title":"PLoS Pathog"},{"key":"10.1111\/cmi.12389-BIB0063|cmi12389-cit-0063","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1128\/IAI.00881-13","article-title":"Assembly of NADPH oxidase in human neutrophils is modulated by the opacity-associated protein expression state of Neisseria gonorrhoeae","volume":"82","author":"Smirnov","year":"2014","journal-title":"Infect Immun"},{"key":"10.1111\/cmi.12389-BIB0064|cmi12389-cit-0064","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.1182\/blood.V97.12.3951","article-title":"Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3","volume":"97","author":"Sorensen","year":"2001","journal-title":"Blood"},{"key":"10.1111\/cmi.12389-BIB0065|cmi12389-cit-0065","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0092-8674(86)90366-1","article-title":"Opacity genes in Neisseria gonorrhoeae: control of phase and antigenic variation","volume":"47","author":"Stern","year":"1986","journal-title":"Cell"},{"key":"10.1111\/cmi.12389-BIB0066|cmi12389-cit-0066","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/j.1365-2958.2005.04839.x","article-title":"The transcriptome response of Neisseria gonorrhoeae to hydrogen peroxide reveals genes with previously uncharacterized roles in oxidative damage protection","volume":"58","author":"Stohl","year":"2005","journal-title":"Mol Microbiol"},{"key":"10.1111\/cmi.12389-BIB0067|cmi12389-cit-0067","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00399-13","article-title":"Neisseria gonorrhoeae metalloprotease NGO1686 is required for full piliation, and piliation is required for resistance to H2O2- and neutrophil-mediated killing","volume":"4","author":"Stohl","year":"2013","journal-title":"MBio"},{"key":"10.1111\/cmi.12389-BIB0068|cmi12389-cit-0068","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1128\/IAI.21.1.292-302.1978","article-title":"Studies on gonococcus infection. XIV. Cell wall protein differences among color\/opacity colony variants of Neisseria gonorrhoeae","volume":"21","author":"Swanson","year":"1978","journal-title":"Infect Immun"},{"key":"10.1111\/cmi.12389-BIB0069|cmi12389-cit-0069","doi-asserted-by":"crossref","first-page":"4871","DOI":"10.1182\/blood-2009-05-220806","article-title":"Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection","volume":"114","author":"Van Ziffle","year":"2009","journal-title":"Blood"},{"key":"10.1111\/cmi.12389-BIB0070|cmi12389-cit-0070","doi-asserted-by":"crossref","first-page":"24825","DOI":"10.1074\/jbc.M302803200","article-title":"Crystal structure of neisserial surface protein A (NspA), a conserved outer membrane protein with vaccine potential","volume":"278","author":"Vandeputte-Rutten","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1111\/cmi.12389-BIB0071|cmi12389-cit-0071","first-page":"503","article-title":"The effect of protein II and pili on the interaction of Neisseria gonorrhoeae with human polymorphonuclear leucocytes","volume":"132","author":"Virji","year":"1986","journal-title":"J Gen Microbiol"},{"key":"10.1111\/cmi.12389-BIB0072|cmi12389-cit-0072","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1046\/j.1365-2958.1996.01551.x","article-title":"Carcinoembryonic antigens (CD66) on epithelial cells and neutrophils are receptors for Opa proteins of pathogenic neisseriae","volume":"22","author":"Virji","year":"1996","journal-title":"Mol Microbiol"},{"key":"10.1111\/cmi.12389-BIB0073|cmi12389-cit-0073","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1046\/j.1365-2958.1998.01102.x","article-title":"Opa binding to cellular CD66 receptors mediates the transcellular traversal of Neisseria gonorrhoeae across polarized T84 epithelial cell monolayers","volume":"30","author":"Wang","year":"1998","journal-title":"Mol Microbiol"},{"key":"10.1111\/cmi.12389-BIB0074|cmi12389-cit-0074","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1242\/jcs.00937","article-title":"GTPases and reactive oxygen species: switches for killing and signaling","volume":"117","author":"Werner","year":"2004","journal-title":"J Cell Sci"},{"key":"10.1111\/cmi.12389-BIB0075|cmi12389-cit-0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0011-5029(80)80002-2","article-title":"Gonococcal diseases","volume":"26","author":"Wiesner","year":"1980","journal-title":"Dis Mon"},{"key":"10.1111\/cmi.12389-BIB0076|cmi12389-cit-0076","unstructured":"World Health Organization 2012 Global incidence and prevalence of selected curable sexually transmitted infections - 2008"},{"key":"10.1111\/cmi.12389-BIB0077|cmi12389-cit-0077","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1128\/IAI.00825-08","article-title":"A strain-specific catalase mutation and mutation of the metal-binding transporter gene mntC attenuate Neisseria gonorrhoeae in vivo but not by increasing susceptibility to oxidative killing by phagocytes","volume":"77","author":"Wu","year":"2009","journal-title":"Infect Immun"},{"key":"10.1111\/cmi.12389-BIB0078|cmi12389-cit-0078","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0955-0674(03)00103-0","article-title":"Leukocyte-epithelial interactions","volume":"15","author":"Zen","year":"2003","journal-title":"Curr Opin Cell Biol"}],"container-title":["Cellular Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcmi.12389","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/cmi.12389\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T12:11:28Z","timestamp":1689595888000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cmi.12389"}},"subtitle":["Killing of Opa+ gonococci in neutrophil phagosomes"],"short-title":[],"issued":{"date-parts":[[2014,11,25]]},"references-count":78,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"URL":"https:\/\/doi.org\/10.1111\/cmi.12389","relation":{},"ISSN":["1462-5814"],"issn-type":[{"value":"1462-5814","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11,25]]}}}