{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T02:29:29Z","timestamp":1759026569152},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,11,22]],"date-time":"2012-11-22T00:00:00Z","timestamp":1353542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cerebrospinal fluid (<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>) biomarkers reflect changes in the brain, and contribute to early screening. Maternal inheritance is putatively stronger than paternal inheritance for late\u2010onset <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>lzheimer's disease (<jats:styled-content style=\"fixed-case\">LOAD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical data of 162 cognitively normal subjects were reviewed. A standard questionnaire was used to identify <jats:styled-content style=\"fixed-case\">LOAD<\/jats:styled-content> family history. Mini\u2010mental state examination (<jats:styled-content style=\"fixed-case\">MMSE<\/jats:styled-content>) was used to evaluate cognition. <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> A\u03b21\u201040, A\u03b21\u201042, total and phosphorylated tau were measured using <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To compare biomarkers in cognitively normal elderly subjects with versus without <jats:styled-content style=\"fixed-case\">LOAD<\/jats:styled-content> family history.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 162 subjects, 38 and 60 had <jats:styled-content style=\"fixed-case\">LOAD<\/jats:styled-content> family history on paternal and maternal sides, respectively. The remaining 60 subjects had no family history. No difference was noted in age, gender, education level, <jats:styled-content style=\"fixed-case\">MMSE<\/jats:styled-content> score, and memory impairment complaint in the three groups. A\u03b242 and the A\u03b242\/40 ratio were lower than in subjects with a maternal history than in subjects with a paternal history or without family history (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05 in both). Phosphorylated and total tau did not differ among the three groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Offspring with a family history of <jats:styled-content style=\"fixed-case\">LOAD<\/jats:styled-content> on the maternal side have lower A\u03b242 and A\u03b242\/40 ratio in the <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>, and maybe at higher risk for developing <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.12028","type":"journal-article","created":{"date-parts":[[2012,11,22]],"date-time":"2012-11-22T11:37:32Z","timestamp":1353584252000},"page":"38-42","source":"Crossref","is-referenced-by-count":13,"title":["A Cross\u2010Sectional Study on Cerebrospinal Fluid Biomarker Levels in Cognitively Normal Elderly Subjects With or Without a Family History of Alzheimer's 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