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They are believed to participate in endothelial repair and postnatal angiogenesis due to their abilities of differentiating into endothelial cells and secreting protective cytokines and growth factors. Mounting evidence suggests that circulating <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>s are reduced and dysfunctional in various diseases including hypertension, diabetes, coronary heart disease, and ischemic stroke. Therefore, <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>s have been documented to be a potential biomarker for vascular diseases and a hopeful candidate for regenerative medicine. Ischemic stroke, as the major cause of disability and death, still has limited therapeutics based on the approaches of vascular recanalization or neuronal protection. Emerging evidence indicates that transplantation of <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>s is beneficial for the recovery of ischemic cerebral injury. <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>\u2010based therapy could open a new avenue for ischemic cerebrovascular disease. Currently, clinical trials for evaluating <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content> transfusion in treating ischemic stroke are underway. In this review, we summarize the general conceptions and the characteristics of <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>s, and highlight the recent research developments on <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>s. More importantly, the rationale, perspectives, and strategies for using them to treat ischemic stroke will be discussed.<\/jats:p>","DOI":"10.1111\/cns.12040","type":"journal-article","created":{"date-parts":[[2012,12,11]],"date-time":"2012-12-11T18:50:27Z","timestamp":1355251827000},"page":"67-75","source":"Crossref","is-referenced-by-count":91,"title":["Endothelial Progenitor Cells: Therapeutic Perspective for Ischemic Stroke"],"prefix":"10.1111","volume":"19","author":[{"given":"Yu\u2010Hui","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Neurology the First Affiliated Hospital of Guangxi Medical University Nanning Guangxi China"},{"name":"Clinical Research Center the Affiliated Hospital Guangdong Medical College Zhanjiang Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology Boonshoft School of Medicine Wright State University Dayton OH USA"},{"name":"Clinical Research Center the Affiliated Hospital Guangdong Medical College Zhanjiang Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology Boonshoft School of Medicine Wright State University Dayton OH USA"},{"name":"Clinical Research Center the Affiliated Hospital Guangdong Medical College Zhanjiang Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De\u2010Hui","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology Boonshoft School of Medicine Wright State University Dayton OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology Boonshoft School of Medicine Wright State University Dayton OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Neurology the First Affiliated Hospital of Guangxi Medical University Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Fang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology Boonshoft School of Medicine Wright State University Dayton OH USA"},{"name":"Clinical Research Center the Affiliated Hospital Guangdong Medical College Zhanjiang Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182456d46"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.018820"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512143332401"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.574335"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105335"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.584904"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804656"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.181486"},{"key":"e_1_2_11_10_1","first-page":"151","article-title":"Autologous bone marrow stem cell neurotransplantation in stroke patients. 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