{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:43:51Z","timestamp":1760147031415},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,25]],"date-time":"2013-03-25T00:00:00Z","timestamp":1364169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Prior studies have demonstrated the involvement of leptin and cannabinoids in food intake and metabolism. However, the interaction between leptin and cannabinoids in epilepsy has not been studied. This study elucidated the relationship between leptin and cannabinoids in penicillin\u2010induced epileptiform activity in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content>1 receptor agonist, arachidonyl\u20102\u2010chloroethylamide (<jats:styled-content style=\"fixed-case\">ACEA<\/jats:styled-content>), at doses of 2.5 and 7.5\u00a0\u03bcg, the <jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content>1 receptor antagonist, [N\u2010(piperidine\u20101\u2010yl)\u20105\u2010(4\u2010iodophenyl)\u20101\u2010(2,4\u2010dichlorophenyl)\u20104\u2010methyl\u20101H\u2010pyrazole\u20103 carboxamide] (<jats:styled-content style=\"fixed-case\">AM<\/jats:styled-content>\u2010251), at doses of 0.125 and 0.25\u00a0\u03bcg, and leptin, at the dose of 1\u00a0\u03bcg, were administered intracerebroventricularly (i.c.v.) 30\u00a0min after intracortical penicillin (i.c.) application.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Leptin caused proconvulsant activity in all groups. The administration of <jats:styled-content style=\"fixed-case\">AM<\/jats:styled-content>\u2010251, at a dose of 0.25\u00a0\u03bcg, increased the frequency of penicillin\u2010induced epileptiform activity by producing status epilepticus\u2010like activity, whereas <jats:styled-content style=\"fixed-case\">AM<\/jats:styled-content>\u2010251, at a dose of 0.125\u00a0\u03bcg, was not effective when applied alone. <jats:styled-content style=\"fixed-case\">ACEA<\/jats:styled-content>, at a dose of 7.5\u00a0\u03bcg, decreased the frequency of epileptiform activity. Leptin reversed the anticonvulsant activity of <jats:styled-content style=\"fixed-case\">ACEA<\/jats:styled-content> and enhanced the proconvulsant activity of <jats:styled-content style=\"fixed-case\">AM<\/jats:styled-content>\u2010251.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study provides electrophysiological evidence that the proconvulsant activity of leptin is mediated, at least in part, by inhibition of cannabinoids in the experimental model of epilepsy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.12075","type":"journal-article","created":{"date-parts":[[2013,3,25]],"date-time":"2013-03-25T04:47:25Z","timestamp":1364186845000},"page":"222-228","source":"Crossref","is-referenced-by-count":19,"title":["The Role of <scp>CB<\/scp>1\u2010Receptors in the Proconvulsant Effect of Leptin on Penicillin\u2010Induced Epileptiform Activity in Rats"],"prefix":"10.1111","volume":"19","author":[{"given":"Gokhan","family":"Arslan","sequence":"first","affiliation":[{"name":"Department of Physiology Faculty of Medicine University of Ondokuz Mayis Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabiha Kubra","family":"Alici","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Medicine University of Ondokuz Mayis Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Ayyildiz","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Medicine University of Ondokuz Mayis Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erdal","family":"Agar","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Medicine University of Ondokuz Mayis Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,25]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"2223","volume-title":"Harrison's Principles of Internal Medicine","author":"Dichter MA","year":"1994"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.029488"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2007.10.006"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23027"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2010.07.023"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.12.051"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI33009"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1998.274.5.R1468"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/35078085"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2005.09.012"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2010.02.003"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01243-2"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.01.065"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.100354"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2007.08.005"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02098.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/35071088"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.10.021"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5126-05.2006"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20531"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5400.401"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.01.054"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2006.07.037"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03079.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2010.11.008"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2008.04.010"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.051920"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.09.046"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2005.08.066"}],"container-title":["CNS Neuroscience &amp; 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