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This immune tolerance effectively impairs host delayed\u2010type hypersensitivity (<jats:styled-content style=\"fixed-case\">DTH<\/jats:styled-content>) responses. We hypothesized that <jats:styled-content style=\"fixed-case\">ACAID<\/jats:styled-content> could be generated in <jats:styled-content style=\"fixed-case\">BALB<\/jats:styled-content>\/c mice following <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> inoculation of the encephalitogenic antigens myelin oligodendrocyte glycoprotein (<jats:styled-content style=\"fixed-case\">MOG<\/jats:styled-content>) and myelin basic protein (<jats:styled-content style=\"fixed-case\">MBP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used <jats:styled-content style=\"fixed-case\">DTH<\/jats:styled-content> assays and local adoptive transfer (<jats:styled-content style=\"fixed-case\">LAT<\/jats:styled-content>) assays to test whether <jats:styled-content style=\"fixed-case\">MOG<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MBP<\/jats:styled-content>\u2010induced <jats:styled-content style=\"fixed-case\">ACAID<\/jats:styled-content> following their administration into the <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>, whether they elicited this immune tolerance via <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> T cells, and whether their <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> coadministration (<jats:styled-content style=\"fixed-case\">MOG<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MBP<\/jats:styled-content>) induced specific immune tolerance to one or both antigens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We showed that <jats:styled-content style=\"fixed-case\">MOG<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MBP<\/jats:styled-content>\u2010induced <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>\u2010mediated specific immune tolerance, as evident from impaired <jats:styled-content style=\"fixed-case\">DTH<\/jats:styled-content> responses. This antigen\u2010driven <jats:styled-content style=\"fixed-case\">DTH<\/jats:styled-content> suppression was solely mediated via splenic <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells as confirmed by <jats:styled-content style=\"fixed-case\">LAT<\/jats:styled-content> assays. Finally, a single <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> injection with both antigens was sufficient to induce specific immune tolerance to these antigens, as evident from <jats:styled-content style=\"fixed-case\">DTH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LAT<\/jats:styled-content> assays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ACAID T<\/jats:styled-content>\u2010cell regulation could be used as a therapeutic tool in the treatment of complicated autoimmune diseases that involve multiple antigens such as multiple sclerosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.12087","type":"journal-article","created":{"date-parts":[[2013,3,23]],"date-time":"2013-03-23T07:06:34Z","timestamp":1364022394000},"page":"503-510","source":"Crossref","is-referenced-by-count":25,"title":["Eye\u2010Mediated Induction of Specific Immune Tolerance to Encephalitogenic Antigens"],"prefix":"10.1111","volume":"19","author":[{"given":"Shukkur M.","family":"Farooq","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice Eugene Applebaum College of Pharmacy and Health Sciences Wayne State University Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossam M.","family":"Ashour","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice Eugene Applebaum College of Pharmacy and Health Sciences Wayne State University Detroit MI USA"},{"name":"Department of Microbiology and Immunology Faculty of Pharmacy Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2008.382"},{"key":"e_1_2_6_3_1","first-page":"157","article-title":"A second study of the behaviour and fate of skin homografts in rabbits: a report to the war wounds committee of the medical research council","volume":"79","author":"Medawar PB","year":"1945","journal-title":"J Anat"},{"key":"e_1_2_6_4_1","first-page":"58","article-title":"Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye","volume":"29","author":"Medawar PB","year":"1948","journal-title":"Br J Exp Pathol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2008.27"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.12.8331"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.10.5950"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1224"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000099263"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000099251"},{"key":"e_1_2_6_11_1","first-page":"383","article-title":"Characterization of suppressor cells in anterior chamber\u2010associated immune deviation (acaid) induced by soluble antigen. 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