{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:52:44Z","timestamp":1791305564586,"version":"4.3.1"},"reference-count":59,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,4,10]],"date-time":"2013-04-10T00:00:00Z","timestamp":1365552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the impact of obesity on clinical and sleep characteristics in a population of narcoleptic children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from the children diagnosed with idiopathic narcolepsy in the National Reference Centers for Narcolepsy were collected between 2008 and 2011. Clinical and electrophysiological characteristics were compared between obese (body mass index [<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>] greater than P97) and nonobese children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 117 children (65 boys, 59 <jats:italic>de novo<\/jats:italic> patients) had a mean age of 11.6\u00a0\u00b1\u00a03.1\u00a0years on diagnosis. Cataplexy was present in 81%, <jats:styled-content style=\"fixed-case\">DQB<\/jats:styled-content>1*0602 in 91%. Mean <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> was 23.2\u00a0\u00b1\u00a05.2\u00a0kg\/m<jats:sup>2<\/jats:sup> and <jats:styled-content style=\"fixed-case\">BMI <\/jats:styled-content><jats:italic>z<\/jats:italic>\u2010score was 2.9\u00a0\u00b1\u00a02.6. Obesity was found in 60% with a similar prevalence in treated versus <jats:italic>de novo<\/jats:italic> patients and in patients with and without cataplexy. Sleepiness and cataplexy started earlier in obese children. Obese narcoleptic children had lower sleep efficiency, higher apnea hypopnea index and respiratory arousals index (<jats:styled-content style=\"fixed-case\">RAI<\/jats:styled-content>) than nonobese children. <jats:styled-content style=\"fixed-case\">BMI <\/jats:styled-content><jats:italic>z<\/jats:italic>\u2010score was positively correlated with <jats:styled-content style=\"fixed-case\">RAI<\/jats:styled-content>. Obese children were more tired and missed more often school than nonobese children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Obesity affects more than 50% of narcoleptic children, mostly younger at disease onset, and has a deleterious impact on sleep quality as well as on school attendance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.12105","type":"journal-article","created":{"date-parts":[[2013,4,10]],"date-time":"2013-04-10T06:52:49Z","timestamp":1365576769000},"page":"521-528","source":"Crossref","is-referenced-by-count":82,"title":["Impact of Obesity in Children with Narcolepsy"],"prefix":"10.1111","volume":"19","author":[{"given":"Clara Odilia","family":"Inocente","sequence":"first","affiliation":[{"name":"Integrative Physiology of Brain Arousal System CRNL University Lyon 1 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Lavault","sequence":"additional","affiliation":[{"name":"National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic hypersomnia and Kleine\u2010Levin Syndrome (CNR narcolepsie\u2010hypersomnie) Paris France"},{"name":"AP\u2010HP, Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re Unit\u00e9 des Pathologies du Sommeil &amp; 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