{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:57:27Z","timestamp":1791107847358,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T00:00:00Z","timestamp":1369180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2013,9]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Ambulatory arterial stiffness index (AASI<\/jats:styled-content>) has been proposed as a new measure of arterial stiffness for predicting cardio\u2013cerebro\u2013vascular morbidity and mortality. However, there has been no research on the direct relationships between AASI<\/jats:styled-content> and arterial stiffness\u2010determining factors.<\/jats:p><\/jats:sec>Methods<\/jats:title>We utilized beat\u2010to\u2010beat intra\u2010aortic blood pressure (BP<\/jats:styled-content>) telemetry to characterize AASI<\/jats:styled-content> in Wistar\u2013Kyoto (WKY<\/jats:styled-content>) and spontaneously hypertensive rats (SHR<\/jats:styled-content>). By determination of aortic structural components and analysis of their correlations with AASI<\/jats:styled-content>, we provided the first direct evidence for the associations between AASI<\/jats:styled-content> and arterial stiffness\u2010determining factors including the collagen content and collagen\/elastin.<\/jats:p><\/jats:sec>Results<\/jats:title>Ambulatory arterial stiffness index was positively correlated with pulse pressure in both WKY<\/jats:styled-content> and SHR<\/jats:styled-content>, less dependent on BP<\/jats:styled-content> and BP<\/jats:styled-content> variability than pulse pressure, and relatively stable, especially the number of BP<\/jats:styled-content> readings not less than ~36. The correlations between AASI<\/jats:styled-content> and aortic components were comparable for various AASI<\/jats:styled-content> values derived from BP<\/jats:styled-content> readings not less than ~36. Not only AASI<\/jats:styled-content> but also BP<\/jats:styled-content> variability and pulse pressure demonstrated a direct relationship with arterial stiffness.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>These findings indicate AASI<\/jats:styled-content> may become a routine measure in human arterial stiffness assessment. It is recommended to use a cluster of parameters such as AASI<\/jats:styled-content>, BP<\/jats:styled-content> variability, and pulse pressure for evaluating arterial stiffness.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.12120","type":"journal-article","created":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T12:40:18Z","timestamp":1369226418000},"page":"667-674","source":"Crossref","is-referenced-by-count":7,"title":["Telemetric Ambulatory Arterial Stiffness Index, a Predictor of Cardio\u2013Cerebro\u2013Vascular Mortality, is Associated with Aortic Stiffness\u2010Determining Factors"],"prefix":"10.1111","volume":"19","author":[{"given":"Zhi\u2010Yong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pharmacology Second Military Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian\u2010Ying","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Second Military Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai\u2010Long","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Second Military Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Ming","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Second Military Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue\u2010Wen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Second Military Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010Feng","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Second Military Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Lo","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de Pharmacie Centre National de la Recherche Scientifique FRE 3075 Universit\u00e9 de Lyon 1 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao\u2010Yu","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Second Military Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.10.061"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2011.00282.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2011.00266.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2011.00264.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000200695.34024.4c"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000236599.91051.1e"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000244953.62362.41"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2007.10"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328339f9e5"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000200699.74641.c5"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000249703.57478.78"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000259604.67283.69"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32834fca18"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000200701.43172.9a"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000254947.07458.90"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000248120.73770.26"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.106.082248"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3282f52fb9"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3282fbf608"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3282f35265"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2010.240"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e318204bb7b"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000226203.57818.88"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn288"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000257876.87284.3c"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2009.06.005"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1811"},{"key":"e_1_2_7_29_1","first-page":"877","article-title":"Ambulatory blood pressure monitoring","volume":"40","author":"Committee National Heart Foundation and High Blood Pressure Research Council of Australia Ambulatory Blood Pressure Monitoring Consensus Committee","year":"2011","journal-title":"Aust Fam Physician"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200201000-00011"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.26.2.337"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200209000-00033"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200101000-00002"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12057"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12011"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2012.00381.x"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2005.06.003"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-303329"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22236"}],"container-title":["CNS Neuroscience & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcns.12120","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.12120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:12:08Z","timestamp":1696378328000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cns.12120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,22]]},"references-count":38,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1111\/cns.12120"],"URL":"https:\/\/doi.org\/10.1111\/cns.12120","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,22]]}}}