{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:06:14Z","timestamp":1791223574807,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,7,27]],"date-time":"2013-07-27T00:00:00Z","timestamp":1374883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2013,11]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>The close relationship between epileptic seizure and Alzheimer's disease (AD<\/jats:styled-content>) has been demonstrated in the past decade. Valproic acid, a traditional first\u2010line antiepileptic drug, exerted protective effects in transgenic models of AD<\/jats:styled-content>. It remains uncertain whether new antiepileptic drugs could reverse neuropathology and behavioral deficits in AD<\/jats:styled-content> transgenic mice.<\/jats:p><\/jats:sec>Aims<\/jats:title>APP<\/jats:styled-content>swe\/PS<\/jats:styled-content>1dE9 transgenic mice were used in this study, which over express the Swedish mutation of amyloid precursor protein together with presenilin 1 deleted in exon 9. 7\u2010month\u2010old APP<\/jats:styled-content>swe\/PS<\/jats:styled-content>1dE9 transgenic mice were treated daily with 20\u00a0mg\/kg topiramate (TPM<\/jats:styled-content>) and 50\u00a0mg\/kg levetiracetam (LEV<\/jats:styled-content>) for 30\u00a0days by intraperitoneal injection to explore the effects of TPM<\/jats:styled-content> and LEV<\/jats:styled-content> on the neuropathology and behavioral deficits.<\/jats:p><\/jats:sec>Results<\/jats:title>The results indicated that TPM<\/jats:styled-content> and LEV<\/jats:styled-content> alleviated behavioral deficits and reduced amyloid plaques in APP<\/jats:styled-content>swe\/PS<\/jats:styled-content>1dE9 transgenic mice. TPM<\/jats:styled-content> and LEV<\/jats:styled-content> increased A\u03b2 clearance and up\u2010regulated A\u03b2 transport and autophagic degradation. TPM<\/jats:styled-content> and LEV<\/jats:styled-content> inhibited A\u03b2 generation and suppressed \u03b3\u2010secretase activity. TPM<\/jats:styled-content> and LEV<\/jats:styled-content> inhibited GSK<\/jats:styled-content>\u20103\u03b2 activation and increased the activation of AMPK<\/jats:styled-content>\/Akt activation. Further, TPM<\/jats:styled-content> and LEV<\/jats:styled-content> inhibited histone deacetylase activity in vivo<\/jats:italic>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Therefore, TPM<\/jats:styled-content> and LEV<\/jats:styled-content> might have the potential to treat AD<\/jats:styled-content> effectively in patient care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.12144","type":"journal-article","created":{"date-parts":[[2013,7,27]],"date-time":"2013-07-27T03:44:34Z","timestamp":1374896674000},"page":"871-881","source":"Crossref","is-referenced-by-count":117,"title":["Antiepileptics Topiramate and Levetiracetam Alleviate Behavioral Deficits and Reduce Neuropathology in APP<\/scp>swe\/PS<\/scp>1dE9 Transgenic Mice"],"prefix":"10.1111","volume":"19","author":[{"given":"Jian\u2010Quan","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Neurology Nanjing First Hospital Nanjing Medical University Nanjing Jiangsu Province 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