{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:25:58Z","timestamp":1778883958759,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,7,27]],"date-time":"2013-07-27T00:00:00Z","timestamp":1374883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the clinical characteristics and sera anti\u2010aquaporin 4 (<jats:styled-content style=\"fixed-case\">AQP<\/jats:styled-content>4) antibody positivity in patients with inflammatory demyelinating disorders (IDDs) of the central nervous system (<jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>) in Tianjin, China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively evaluated 234 patients with IDDs including neuromyelitis optica (NMO), recurrent optic neuritis (<jats:styled-content style=\"fixed-case\">rON<\/jats:styled-content>), longitudinally extensive transverse myelitis (LETM), clinically isolated syndrome (CIS), and multiple sclerosis (MS) groups. Sera from 217 patients were determined for AQP4\u2010Ab. The clinical characteristics and sera anti\u2010AQP4 positivity were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The IDDS comprised 63 MS, 51 NMO, 56 LETM, 10 <jats:styled-content style=\"fixed-case\">rON<\/jats:styled-content>, and 54 CIS. Compared with MS, NMO had a higher frequency of occurrence in women, intractable hiccup and nausea (IHN), medullospinal lesion, longitudinally extensive spinal cord lesions (LESCL) and bilateral ON, disease onset at a later age, and worsening residual disability. AQP4\u2010Ab\u2010positive rates were 84.1% and 69% in NMO and NMO spectrum disorders (NMOSD), respectively, whereas it was undetectable in all of the MS sera samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We comprehensively contrast the distinct clinical features of <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> NMO<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">NMOSD<\/jats:styled-content> in our center. A sensitive <jats:styled-content style=\"fixed-case\">AQP<\/jats:styled-content>4\u2010Ab assay is necessary for the early diagnosis of <jats:styled-content style=\"fixed-case\">NMOSD<\/jats:styled-content> in our patients. Neither medullospinal lesion nor <jats:styled-content style=\"fixed-case\">IHN<\/jats:styled-content> is unique in <jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.12156","type":"journal-article","created":{"date-parts":[[2013,7,27]],"date-time":"2013-07-27T07:44:35Z","timestamp":1374911075000},"page":"32-39","source":"Crossref","is-referenced-by-count":26,"title":["Clinical Features and Sera Anti\u2010Aquaporin 4 Antibody Positivity in Patients with Demyelinating Disorders of the Central Nervous System from Tianjin, China"],"prefix":"10.1111","volume":"20","author":[{"given":"Chun\u2010Sheng","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Neurology and Tianjin Neurological Institute Tianjin Medical University General Hospital Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da\u2010Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of 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