{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:07:44Z","timestamp":1790075264744,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T00:00:00Z","timestamp":1385510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">NLRP<\/jats:styled-content>3 inflammasome is a cytoplasmic multiprotein complex of the innate immune system that regulates the cleavage of interleukin\u20101\u03b2 and interleukin\u201018 precursors. It can detect a wide range of danger signals and trigger a series of immune\u2010inflammatory reactions. There were plenty of studies indicating that activation of the immune system played pivotal roles in depression. However, the underlying mechanisms of immune\u2010depression interactions remained elusive and there was no report about the involvement of inflammasome activation in depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We established an acute depression mouse model with lipopolysaccharide to explore the involvement of inflammasome activation in depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The lipopolysaccharide\u2010treated mice displayed depressive\u2010like behaviors and pro\u2010inflammatory cytokine interleukin\u20101\u03b2 protein and m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> levels significantly increased. The <jats:styled-content style=\"fixed-case\">NLRP<\/jats:styled-content>3 inflammasome m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> expression level also significantly elevated in depressed mice brain. Pretreatment with the <jats:styled-content style=\"fixed-case\">NLRP<\/jats:styled-content>3 inflammasome inhibitor <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>c\u2010<jats:styled-content style=\"fixed-case\">YVAD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CMK<\/jats:styled-content> significantly abrogated the depressive\u2010like behaviors induced by lipopolysaccharide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data suggest for the first time that the <jats:styled-content style=\"fixed-case\">NLRP<\/jats:styled-content>3 inflammasome is involved in lipopolysaccharide\u2010induced mice depressive\u2010like behaviors. The <jats:styled-content style=\"fixed-case\">NLRP<\/jats:styled-content>3 inflammasome may be a central mediator between immune activation and depression, which raises the possibility that it may be a more specific target for the depression treatments in the near future.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.12170","type":"journal-article","created":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T12:18:15Z","timestamp":1385554695000},"page":"119-124","source":"Crossref","is-referenced-by-count":187,"title":["Involvement of Inflammasome Activation in Lipopolysaccharide\u2010induced Mice Depressive\u2010like Behaviors"],"prefix":"10.1111","volume":"20","author":[{"given":"Yi","family":"Zhang","sequence":"first","affiliation":[{"name":"Laboratory of Stress Medicine Faculty of Psychology and Mental Health Second Military Medical University Shanghai 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