{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T10:16:54Z","timestamp":1763201814169},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T00:00:00Z","timestamp":1385510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Primary filum terminale ependymoma (<jats:styled-content style=\"fixed-case\">PFTE<\/jats:styled-content>) is a unique type of ependymomas and locates on extramedullary site. However, the clinical features and prognostic factors of <jats:styled-content style=\"fixed-case\">PFTE<\/jats:styled-content> are still unknown due to its rarity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to evaluate the clinical features, outcomes, and prognostic factors of <jats:styled-content style=\"fixed-case\">PFTE<\/jats:styled-content> in the largest series of cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Thirty\u2010eight patients were included in this study. Gross total removal (<jats:styled-content style=\"fixed-case\">GTR<\/jats:styled-content>) of the tumors was achieved in 33(87%) patients. Five (13%) patients had subtotal resection (<jats:styled-content style=\"fixed-case\">STR<\/jats:styled-content>). For the residual tumors, postoperative radiotherapy increased the interval between the first surgery and tumor regrowth (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.063). Six patients had local recurrence\/progression. Univariate analysis identified <jats:styled-content style=\"fixed-case\">STR<\/jats:styled-content>(<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001), unencapsulated tumor (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.018), tumor involving more than two vertebral columns (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.005), and tumor invading sacral canal(<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001) as predictors of tumor recurrence. In addition, 36 (95%) patients had stable or improved neurological status directly after surgery. Klekamp\u2013Samii score was better correlated with the symptoms than McCormick scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Extent of surgical removal, tumor size, tumor location, and the integrity of tumor capsule are the prognostic factors of <jats:styled-content style=\"fixed-case\">PFTE<\/jats:styled-content>s, and the intrasacral <jats:styled-content style=\"fixed-case\">PFTE<\/jats:styled-content>s always have a poor prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.12174","type":"journal-article","created":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T12:18:31Z","timestamp":1385554711000},"page":"131-139","source":"Crossref","is-referenced-by-count":6,"title":["Surgery for Primary Filum Terminale Ependymomas: Outcome and Prognostic Factors"],"prefix":"10.1111","volume":"20","author":[{"given":"Tian\u2010Hao","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Changzheng Hospital Second Military 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