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These prescription drugs are not free of side effects, and the patients usually suffer from anxiety and depression. We investigated quercetin, a dietary flavonoid with free radical scavenging properties, for its beneficial potential if any, in 3\u2010nitropropionic acid (3\u2010<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>)\u2010induced <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> in rats where both drugs were administered simultaneously.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Performance of rats on beam balancing, elevated plus maze and gait traits were investigated following 3\u2010<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> and\/or quercetin treatments for 4\u00a0days. Striatal biogenic amine levels and monoamine oxidase activity were assayed. Striatal sections were examined for Cd11B and glial fibrillary acidic protein immunoreactivity, and for evidences of neuronal lesion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Quercetin significantly attenuated 3\u2010<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>\u2010induced anxiety, motor coordination deficits, and gait despair. While the dopaminergic hyper\u2010metabolism was unaffected, quercetin provided a significant reduction of 3\u2010<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> mediated increase in serotonin metabolism. Quercetin failed to affect 3\u2010<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>\u2010induced striatal neuronal lesion, but decreased microglial proliferation, and increased astrocyte numbers in the lesion core.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results taken together suggest that quercetin could be of potential use not only for correcting movement disturbances and anxiety in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>, but also for addressing inflammatory damages.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.12189","type":"journal-article","created":{"date-parts":[[2013,11,5]],"date-time":"2013-11-05T05:16:57Z","timestamp":1383628617000},"page":"10-19","source":"Crossref","is-referenced-by-count":129,"title":["Quercetin Improves Behavioral Deficiencies, Restores Astrocytes and Microglia, and Reduces Serotonin Metabolism in 3\u2010Nitropropionic Acid\u2010Induced Rat Model of Huntington's 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