{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T05:05:36Z","timestamp":1773810336678,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,12,6]],"date-time":"2013-12-06T00:00:00Z","timestamp":1386288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Glioblastoma multiforme (<jats:styled-content style=\"fixed-case\">GBM<\/jats:styled-content>) is one of the most frequent human brain tumor and causes dismal outcome. To identify tumor\u2010associated antigens in GBM patients may find potential diagnostic markers and immunotherapeutic targets. In this study, we identified a gene termed <jats:italic>URGCP<\/jats:italic> using the serological identification of antigens by recombinant A2B5 positive glioma <jats:styled-content style=\"fixed-case\">cDNA<\/jats:styled-content> library. The gene product of URGCP is immunogenic in GBM after tested in allogenic patients serum screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">GBM<\/jats:styled-content> patients with an auto\u2010antibody response against <jats:styled-content style=\"fixed-case\">URGCP<\/jats:styled-content> show longer survival than those without <jats:styled-content style=\"fixed-case\">URGCP<\/jats:styled-content> response. In additional, we show that <jats:styled-content style=\"fixed-case\">URGCP<\/jats:styled-content> was high expression in most <jats:styled-content style=\"fixed-case\">GBM<\/jats:styled-content> tissues and cell lines compared with normal brain tissues and majorly co\u2010expressed with stem cell marker A2B5.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We identified a potential new biomarker of <jats:styled-content style=\"fixed-case\">GBM<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> URGCP<\/jats:styled-content>. The findings indicate that <jats:styled-content style=\"fixed-case\">URGCP<\/jats:styled-content> is immunogenic in human <jats:styled-content style=\"fixed-case\">GBM<\/jats:styled-content> and suggest its potential use as diagnostic and immunotherapeutic for <jats:styled-content style=\"fixed-case\">GBM<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.12214","type":"journal-article","created":{"date-parts":[[2013,12,6]],"date-time":"2013-12-06T09:39:11Z","timestamp":1386322751000},"page":"301-307","source":"Crossref","is-referenced-by-count":11,"title":["Serological Identification of <scp>URGCP<\/scp> as a Potential Biomarker for Glioma"],"prefix":"10.1111","volume":"20","author":[{"given":"Ling\u2010Chao","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Huashan Hospital Fudan University Shanghai 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