{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:30:47Z","timestamp":1787661047401,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T00:00:00Z","timestamp":1395014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Natutal Scientific Foundation of China","award":["30930080"],"award-info":[{"award-number":["30930080"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2014,8]]},"abstract":"Summary<\/jats:title>\n \n Aims<\/jats:title>\n \n To investigate the role of astrocytic\n JWA<\/jats:styled-content>\n expression in dopaminergic (DA) neuron degeneration and in the pathogenesis of Parkinson's disease (PD).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Conditional astrocytic\n JWA<\/jats:styled-content>\n null (\n JWA<\/jats:styled-content>\n \u22062\/\u22062<\/jats:sup>\n \/\n GFAP<\/jats:styled-content>\n \u2010Cre) mice and U251 glioma cells were used to evaluate the effects of\n JWA<\/jats:styled-content>\n gene on DA neuron degeneration. The oxidative stress\u2010driven molecular events were determined in both\n in\u00a0vivo<\/jats:italic>\n and\n in\u00a0vitro<\/jats:italic>\n models.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Conditional astrocytic\n JWA<\/jats:styled-content>\n knockout resulted in significant activation of astrocytes measured by increase in glial fibrillary acidic protein\u2010positive cells (1.34\u00a0\u00d7\u00a010\n 3<\/jats:sup>\n \u00a0\u00b1\u00a074.5 vs. 8.44\u00a0\u00d7\u00a010\n 3<\/jats:sup>\n \u00a0\u00b1\u00a01.35\u00a0\u00d7\u00a010\n 3<\/jats:sup>\n ,\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.01) in mouse substantia nigra, accompanied by loss of DA neurons (1.03\u00a0\u00d7\u00a010\n 4<\/jats:sup>\n \u00a0\u00b1\u00a0238 vs. 6.17\u00a0\u00d7\u00a010\n 3<\/jats:sup>\n \u00a0\u00b1\u00a0392,\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.001). Deficiency of\n JWA<\/jats:styled-content>\n significantly aggravated reactive oxygen species (ROS) accumulation in substantia nigra compared with the wild\u2010type mice. Increasing\n JWA<\/jats:styled-content>\n expression in U251 glioma cells inhibited ROS with a concomitant increase in intracellular glutathione. Furthermore, suppression of\n IKK<\/jats:styled-content>\n \u03b2<\/jats:italic>\n \u2010nuclear factor (\n NF<\/jats:styled-content>\n )\u2010\n \u03ba<\/jats:italic>\n B signaling pathway was shown to regulate\n JWA<\/jats:styled-content>\n in a PD model.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The\n JWA<\/jats:styled-content>\n gene exerts neuroprotective roles against DA neuronal degeneration via modulating intracellular redox status and\n NF<\/jats:styled-content>\n \u2010\n \u03ba<\/jats:italic>\n B signaling pathway and is a potential treatment target for PD.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cns.12249","type":"journal-article","created":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T02:22:50Z","timestamp":1395022970000},"page":"754-762","source":"Crossref","is-referenced-by-count":20,"title":["Astrocytic\n JWA<\/scp>\n Expression is Essential to Dopaminergic Neuron Survival in the Pathogenesis of Parkinson's Disease"],"prefix":"10.1111","volume":"20","author":[{"given":"Shu\u2010Han","family":"Miao","sequence":"first","affiliation":[{"name":"Department of Molecular Cell Biology and Toxicology School of Public Health Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Bin","family":"Sun","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Neurodegeneration Department of Pharmacology Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology and Toxicology School of Public Health Nanjing Medical University Nanjing Jiangsu China"},{"name":"Department of Preventive Medicine School of Medical Science and Laboratory Medicine Jiangsu University Zhenjiang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology and Toxicology School of Public Health Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao\u2010Wei","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology and Toxicology School of Public Health Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Lu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Neurodegeneration Department of Pharmacology Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Hu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Neurodegeneration Department of Pharmacology 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