{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:33:03Z","timestamp":1765827183859,"version":"3.40.4"},"reference-count":58,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,4,7]],"date-time":"2014-04-07T00:00:00Z","timestamp":1396828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD 070611"],"award-info":[{"award-number":["HD 070611"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2014,7]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Converging evidence points to the involvement of\u03b3<\/jats:italic>\u2010amino\u2010butyric acidB<\/jats:styled-content>receptors (GABA<\/jats:styled-content>B<\/jats:sub>R<\/jats:styled-content>s) in the regulation of information processing. We previously showed thatGABA<\/jats:styled-content>B<\/jats:sub>R<\/jats:styled-content>agonists exhibit antipsychotic\u2010like properties in rodent models of sensorimotor gating deficits, as measured by the prepulse inhibition (PPI<\/jats:styled-content>) of the acoustic startle reflex. The therapeutic potential of these agents, however, is limited by their neuromuscular side effects; thus, in this study, we analyzed whetherrac<\/jats:italic>\u2010BHFF<\/jats:styled-content>, a potentGABA<\/jats:styled-content>B<\/jats:sub>R<\/jats:styled-content>\u2010positive allosteric modulator (PAM<\/jats:styled-content>), could counter spontaneous and pharmacologically inducedPPI<\/jats:styled-content>deficits across various rodent models.<\/jats:p><\/jats:sec>Methods<\/jats:title>We tested the antipsychotic effects ofrac<\/jats:italic>\u2010BHFF<\/jats:styled-content>on thePPI<\/jats:styled-content>deficits caused by theN<\/jats:styled-content><\/jats:italic>\u2010methyl\u2010D<\/jats:styled-content>\u2010aspartate glutamate receptor antagonist dizocilpine, inS<\/jats:styled-content>prague\u2010D<\/jats:styled-content>awley rats andC<\/jats:styled-content>57BL<\/jats:styled-content>\/6 mice. Furthermore, we verified whetherrac<\/jats:italic>\u2010BHFF<\/jats:styled-content>ameliorated the spontaneousPPI<\/jats:styled-content>impairments inDBA<\/jats:styled-content>\/2J<\/jats:styled-content>mice.<\/jats:p><\/jats:sec>Results<\/jats:title>rac<\/jats:italic>\u2010BHFF<\/jats:styled-content>dose\u2010dependently countered thePPI<\/jats:styled-content>deficits across all three models, in a fashion akin to theGABA<\/jats:styled-content>B<\/jats:sub>R<\/jats:styled-content>agonist baclofen and the atypical antipsychotic clozapine; in contrast with these compounds, however,rac<\/jats:italic>\u2010BHFF<\/jats:styled-content>did not affect startle magnitude.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The present data further support the implication ofGABA<\/jats:styled-content>B<\/jats:sub>R<\/jats:styled-content>s in the modulation of sensorimotor gating and point to theirPAM<\/jats:styled-content>s as a novel promising tool for antipsychotic treatment, with fewer side effects thanGABA<\/jats:styled-content>B<\/jats:sub>R<\/jats:styled-content>agonists.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.12261","type":"journal-article","created":{"date-parts":[[2014,4,7]],"date-time":"2014-04-07T07:09:52Z","timestamp":1396854592000},"page":"679-684","source":"Crossref","is-referenced-by-count":13,"title":["Positive Allosteric Modulation ofGABA<\/scp>B<\/sub>Receptors Ameliorates Sensorimotor Gating in Rodent Models"],"prefix":"10.1111","volume":"20","author":[{"given":"Roberto","family":"Frau","sequence":"first","affiliation":[{"name":"\u201cGuy Everett\u201d Laboratory Department of Biomedical Sciences University of Cagliari Cagliari Italy"},{"name":"Tourette Syndrome Center University of Cagliari Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Bini","sequence":"additional","affiliation":[{"name":"\u201cGuy Everett\u201d Laboratory Department of Biomedical Sciences University of Cagliari Cagliari Italy"},{"name":"Tourette Syndrome Center University of Cagliari Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuliano","family":"Pillolla","sequence":"additional","affiliation":[{"name":"\u201cGuy Everett\u201d Laboratory Department of Biomedical Sciences University of Cagliari Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pari","family":"Malherbe","sequence":"additional","affiliation":[{"name":"DTA Neuroscience F. 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