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An episode of hypoxia\u2013ischemia causes rapid and severe damage to these particularly vulnerable cells via multiple pathways such as overactivation of glutamate and <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content> receptors, oxidative stress, and disruption of mitochondrial function. The cardinal effect of <jats:styled-content style=\"fixed-case\">OL<\/jats:styled-content> pathology is demyelination and dysmyelination, and this has profound effects on axonal function, transport, structure, metabolism, and survival. The <jats:styled-content style=\"fixed-case\">OL<\/jats:styled-content> is a primary target of ischemia in adult\u2010onset stroke and especially in periventricular leukomalacia and should be considered as a primary therapeutic target in these conditions. More emphasis is needed on therapeutic strategies that target <jats:styled-content style=\"fixed-case\">OL<\/jats:styled-content>s, myelin, and their receptors, as these have the potential to significantly attenuate white matter injury and to establish functional recovery of white matter after stroke. In this review, we will summarize recent progress on the role of <jats:styled-content style=\"fixed-case\">OL<\/jats:styled-content>s in white matter ischemic injury and the current and emerging principles that form the basis for protective strategies against <jats:styled-content style=\"fixed-case\">OL<\/jats:styled-content> death.<\/jats:p>","DOI":"10.1111\/cns.12263","type":"journal-article","created":{"date-parts":[[2014,4,7]],"date-time":"2014-04-07T06:57:51Z","timestamp":1396853871000},"page":"603-612","source":"Crossref","is-referenced-by-count":114,"title":["Oligodendrocyte Pathophysiology and Treatment Strategies in Cerebral Ischemia"],"prefix":"10.1111","volume":"20","author":[{"given":"Gabriella","family":"Mifsud","sequence":"first","affiliation":[{"name":"Department of Physiology and Biochemistry Faculty of Medicine and Surgery University of Malta Msida 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