{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:52:49Z","timestamp":1791305569826,"version":"4.3.1"},"reference-count":53,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,6,12]],"date-time":"2014-06-12T00:00:00Z","timestamp":1402531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the health\u2010related quality of life (<jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content>) and its correlates in children and adolescents with narcolepsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared the clinical characteristics of control subjects and patients with primary narcolepsy from data collected at the National Reference Centers for Narcolepsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort included 69 control subjects (29 boys) and 117 patients (65 boys; 59 <jats:italic>de novo<\/jats:italic> patients). Cataplexy was present in 81% and <jats:styled-content style=\"fixed-case\">DQB<\/jats:styled-content>1*0602 was positive in 91%. The control children were older (13.5\u00a0\u00b1\u00a03.2 vs. 11.6\u00a0\u00b1\u00a03.1\u00a0years, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) and less obese (1.4% vs. 60%, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). Twenty\u2010five percent of the patients and 15.6% of the control subjects had clinically significant depressive feelings on Children's Depression Inventory (<jats:styled-content style=\"fixed-case\">CDI<\/jats:styled-content>\u00a0\u2265\u00a016) (<jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>). Fifty\u2010three narcoleptic and 43 control adolescents, 31 narcoleptic children and 23 control children filled out the <jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content> questionnaires as well as 83 parents of patients and 60 parents of control subjects. Narcolepsy seriously impacts <jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content> in terms of vitality, physical well\u2010being, relations with friends and leisure activities, especially in adolescents. Depression was the factor that most affected <jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content> in both narcoleptic and control subjects. For the control subjects and the narcoleptic patients, when the <jats:styled-content style=\"fixed-case\">CDI<\/jats:styled-content> score was entered into the multivariable regression model adjusted for gender and age, no other continuous independent variable could significantly increase the likelihood of the model. When the <jats:styled-content style=\"fixed-case\">CDI<\/jats:styled-content> score increased by 1, the mean <jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content> score decreased by 1.7 for narcoleptic patients and 1.5 for control subjects. Apnea\u2013hypopnoea index, diagnosis delay, disease duration, obesity, the presence of cataplexy or treatment had no effects on <jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Narcoleptic children and adolescents were at high risk for poor <jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content>. Depressive symptoms had a major impact on <jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content>. We recommend a more thorough assessment and management of psychological health in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.12291","type":"journal-article","created":{"date-parts":[[2014,6,12]],"date-time":"2014-06-12T12:38:36Z","timestamp":1402576716000},"page":"763-771","source":"Crossref","is-referenced-by-count":77,"title":["Quality of Life in Children with Narcolepsy"],"prefix":"10.1111","volume":"20","author":[{"given":"Clara O.","family":"Inocente","sequence":"first","affiliation":[{"name":"Integrative Physiology of Brain Arousal System CRNL INSERM\u2010U1028 CNRS UMR5292 University Lyon1 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Paule","family":"Gustin","sequence":"additional","affiliation":[{"name":"Department of Public Health Universit\u00e9 Lyon 1 Institute of Pharmacy (ISPB) Universit\u00e9 de Lyon, EA4173 Lyon France"},{"name":"Service de Biostatistique Hospices Civils de Lyon Lyon Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Lavault","sequence":"additional","affiliation":[{"name":"National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic hypersomnia and Kleine\u2010Levin Syndrome (CNR Narcolepsie\u2010Hypersomnie) Paris France"},{"name":"AP\u2010HP Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re Unit\u00e9 des Pathologies du Sommeil &amp; 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