{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T03:27:07Z","timestamp":1780457227458,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,6,23]],"date-time":"2014-06-23T00:00:00Z","timestamp":1403481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81273505"],"award-info":[{"award-number":["81273505"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81230083"],"award-info":[{"award-number":["81230083"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2014,9]]},"abstract":"Summary<\/jats:title>Aim<\/jats:title>Anticoagulants are commonly used to treat ischemic stroke. Its impact on cerebellar infarction has not been fully understood.<\/jats:p><\/jats:sec>Methods<\/jats:title>In the clinical study, we reviewed a consecutive series of patients with large\u2010sized cerebellar infarction (diameter\u00a0>\u00a03\u00a0cm, n\u00a0=\u00a030) treated with or without anticoagulation. In animal study, cerebellar infarction operation was performed in 12 C<\/jats:styled-content>ynomolgus monkeys. Then the animals were administrated with low molecular weight heparin (LMWH<\/jats:styled-content>) or vehicle for 14\u00a0days.<\/jats:p><\/jats:sec>Results<\/jats:title>Six patients died during the following treatment. All the subjects that died received anticoagulation therapy, while nobody in the survival group received such a therapy. Compared with sham\u2010operated animals, all monkeys with cerebellar infarction have obvious neurological deficits. The number and size of the P<\/jats:styled-content>urkinje cells in the cerebellar area were also reduced. Two animals in the LMWH<\/jats:styled-content> group (33%) died, while all animals in the vehicle control group survived. Compared with the vehicle group, the neurological score in the LMWH<\/jats:styled-content> group was significantly increased (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.05). The water content in the cerebella was also significantly higher (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.05). Edema, hemorrhage, and subarachnoid hemorrhage occurred in the cerebella as well as brainstem of all the LMWH<\/jats:styled-content> treated animals.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>These results indicated the harmful effects of anticoagulation therapy on large\u2010sized cerebellar infarction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.12299","type":"journal-article","created":{"date-parts":[[2014,6,23]],"date-time":"2014-06-23T13:26:13Z","timestamp":1403529973000},"page":"867-873","source":"Crossref","is-referenced-by-count":5,"title":["Anticoagulation Therapy is Harmful to Large\u2010Sized Cerebellar Infarction"],"prefix":"10.1111","volume":"20","author":[{"given":"She\u2010Qing","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology Changhai Hospital Second Military Medical University Shanghai 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