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Twenty\u2010five patients diagnosed with <jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content> were enrolled in the study. Patients were administered questionnaires on pain, anxiety, depression, quality of life, and cognitive impairment, and single\u2010voxel <jats:styled-content style=\"fixed-case\">MRS<\/jats:styled-content> of the brain was performed. All assessments were performed at baseline and after 6\u00a0months of treatment with memantine or placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients treated with memantine exhibited a significant increase in the glutamate (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.010), glutamate\/creatine ratio (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.013), combined glutamate + glutamine (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.016) and total <jats:italic>N<\/jats:italic>\u2010acetyl\u2010aspartate (<jats:styled-content style=\"fixed-case\">NAA<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">NAAG<\/jats:styled-content>) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.034) in the posterior cingulate cortex compared with those on placebo. Furthermore, the memantine group exhibited increases in creatine (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.013) and choline (Cho) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.025) in the right posterior insula and also a correlation between choline and the Fibromyalgia Impact Questionnaire (<jats:styled-content style=\"fixed-case\">FIQ<\/jats:styled-content>) in the posterior insula (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.050) was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Memantine treatment resulted in an increase in cerebral metabolism in <jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content> patients, suggesting its utility for the treatment of the illness.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.12314","type":"journal-article","created":{"date-parts":[[2014,9,17]],"date-time":"2014-09-17T11:56:05Z","timestamp":1410954965000},"page":"999-1007","source":"Crossref","is-referenced-by-count":31,"title":["Changes in Metabolites after Treatment with Memantine in Fibromyalgia. 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