{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:00:32Z","timestamp":1788872432417,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"The Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81071051"],"award-info":[{"award-number":["81071051"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      Mounting evidence showed that\n                      <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content>\n                      ergic interneurons play an important role in the generation of seizures by regulating excitatory\/inhibitory balance in the hippocampus; however, there is a continuous debate regarding the alteration in the number of hippocampal\n                      <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content>\n                      ergic interneurons during epileptogenesis. Here, we investigated the degeneration and regeneration of\n                      <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content>\n                      ergic interneurons in the dentate gyrus during epileptogenesis using glutamic acid decarboxylase\u2010green fluorescence protein (\n                      <jats:styled-content style=\"fixed-case\">GAD<\/jats:styled-content>\n                      67\u2010\n                      <jats:styled-content style=\"fixed-case\">GFP<\/jats:styled-content>\n                      ) knock\u2010in mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      Pentylenetetrazol (\n                      <jats:styled-content style=\"fixed-case\">PTZ<\/jats:styled-content>\n                      )\u2010induced chronic kindling model and lithium\u2013pilocarpine\u2010induced status epilepticus (\n                      <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\n                      ) model were used in this study. We found a progressive loss of\n                      <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content>\n                      ergic interneurons in the dentate gyrus during post\u2010\n                      <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\n                      epileptogenesis rather than\n                      <jats:styled-content style=\"fixed-case\">PTZ<\/jats:styled-content>\n                      kindling. Both types of epileptogenic insults significantly promoted the proliferation of neural progenitor cells in the dentate gyrus; however, compared to 80% neuronal differentiation ratio in the control group, there was a remarkable decrease in\n                      <jats:styled-content style=\"fixed-case\">PTZ<\/jats:styled-content>\n                      kindling and pilocarpine models, that is 58% and 29%, respectively. Double\/triple immunofluorescence labeling revealed no newborn neurons colabeled with\n                      <jats:styled-content style=\"fixed-case\">GFP<\/jats:styled-content>\n                      in both intact and epileptic dentate gyrus. In addition, valproate (a first\u2010line antiepileptic drug) treatment prevented the loss of\n                      <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content>\n                      ergic interneurons but still failed to induce the regeneration of\n                      <jats:styled-content style=\"fixed-case\">GAD<\/jats:styled-content>\n                      67\u2010positive interneurons in the dentate gyrus during post\u2010\n                      <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\n                      epileptogenesis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These results indicate that degeneration of\n                      <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content>\n                      ergic interneurons may depend on the type of epileptogenic insult and that no newborn\n                      <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content>\n                      ergic interneurons occur in the adult dentate gyrus during epileptogenesis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.12330","type":"journal-article","created":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T08:22:56Z","timestamp":1412151776000},"page":"52-60","source":"Crossref","is-referenced-by-count":21,"title":["Degeneration and Regeneration of\n                    <scp>GABA<\/scp>\n                    ergic Interneurons in the Dentate Gyrus of Adult Mice in Experimental Models of Epilepsy"],"prefix":"10.1111","volume":"21","author":[{"given":"Dong","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Neurology Xijing Hospital Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology Xijing Hospital Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Xijing Hospital Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology Xijing Hospital Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology Xijing Hospital Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2010Xi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Anatomy Histology and Embryology K. 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