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The current stroke treatment of tissue plasminogen activator is limited to the very acute 4.5\u00a0h after disease onset which benefits only less than 3% of ischemic stroke patients. Our overarching hypothesis advances the notion that gender, which has been established as a comorbidity factor of stroke, plays a key role in regenerative medicine, in particular stem cell therapy. We hypothesize that gender is a key factor in culture\u2010induced stemness of adult stem cells. 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