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Even after the recent significant advances in neurobiology, the above\u2010mentioned disorders continue to haunt the global population. Several studies have suggested the role of specific environmental and genetic risk factors associated with these disorders. However, the exact mechanism associated with the progression of these disorders still needs to be elucidated. In the recent years, sophisticated research has revealed interesting association of prominent neurodegenerative disorders such as <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> with chronic diseases such as cancer, diabetes, and cardiovascular diseases. Several common molecular mechanisms such as generation of free radicals, oxidative <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> damage, aberrations in mitochondrial <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>, and dysregulation of apoptosis have been highlighted as possible points of connection. The present review summarizes the possible mechanism of coexistence of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> with other chronic diseases.<\/jats:p>","DOI":"10.1111\/cns.12344","type":"journal-article","created":{"date-parts":[[2014,11,15]],"date-time":"2014-11-15T05:53:16Z","timestamp":1416030796000},"page":"1-7","source":"Crossref","is-referenced-by-count":25,"title":["Synopsis on the Linkage of Alzheimer's and Parkinson's Disease with Chronic Diseases"],"prefix":"10.1111","volume":"21","author":[{"given":"Nasimudeen R.","family":"Jabir","sequence":"first","affiliation":[{"name":"King Fahd Medical Research Center King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chelapram K.","family":"Firoz","sequence":"additional","affiliation":[{"name":"King Fahd Medical Research Center King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saleh S.","family":"Baeesa","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery College of Medicine King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghulam Md","family":"Ashraf","sequence":"additional","affiliation":[{"name":"King Fahd Medical Research Center King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhail","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Center for Intestinal and Liver Inflammation Research Stanley Manne Children's Research Institute Ann and Robert H. 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