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The aim of this study was to investigate whether\n                      <jats:styled-content style=\"fixed-case\">TREK<\/jats:styled-content>\n                      \u20101 plays a role in the therapeutic effects of the selective serotonin reuptake inhibitor (\n                      <jats:styled-content style=\"fixed-case\">SSRI<\/jats:styled-content>\n                      ) escitalopram in a rat\n                      <jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content>\n                      model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The whole\u2010cell patch\u2010clamp technique was performed to assess the effect of escitalopram on recombinant TREK\u20101 currents in HEK293 cells. The expression of TREK\u20101\n                      <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>\n                      and protein was measured in the hippocampus and prefrontal cortex (PFC), and neural stem cell (NSC) proliferation was detected in the hippocampal dentate gyrus (DG) in PSD rats after 3\u00a0weeks of escitalopram administration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Escitalopram reversibly inhibited TREK\u20101 currents in a concentration\u2010dependent manner. Chronic treatment with escitalopram significantly reversed the reductions in weight gain, locomotor activity, and sucrose preference in PSD rats. The expressions of TREK\u20101\n                      <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>\n                      and protein were significantly increased in hippocampal CA1, CA3, DG, and PFC in PSD rats, with the exception of TREK\u20101\n                      <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>\n                      in hippocampal CA1. NSC proliferation was significantly decreased in hippocampal DG of PSD rats. Escitalopram significantly reversed the regional increases of TREK\u20101 expression and the reduction of hippocampal NSC proliferation in PSD rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">TREK<\/jats:styled-content>\n                      \u20101 plays an important role in the therapeutic effects of the\n                      <jats:styled-content style=\"fixed-case\">SSRI<\/jats:styled-content>\n                      escitalopram in\n                      <jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content>\n                      model, making\n                      <jats:styled-content style=\"fixed-case\">TREK<\/jats:styled-content>\n                      \u20101 an attractive candidate molecule for further understanding the pathophysiology and treatment of\n                      <jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.12384","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T16:51:27Z","timestamp":1423759887000},"page":"504-512","source":"Crossref","is-referenced-by-count":22,"title":["The Role of the Two\u2010Pore Domain Potassium Channel\n                    <scp>TREK<\/scp>\n                    \u20101 in the Therapeutic Effects of Escitalopram in a Rat Model of Poststroke Depression"],"prefix":"10.1111","volume":"21","author":[{"given":"Dai\u2010Hua","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Neurology Affiliated with ZhongDa Hospital Neuropsychiatric Institute and Medical School of Southeast University Nanjing 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