{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:37:49Z","timestamp":1791261469801,"version":"4.1.0"},"reference-count":180,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,10]],"date-time":"2015-02-10T00:00:00Z","timestamp":1423526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Stem cell\u2010based therapy for ischemic stroke has been widely explored in animal models and provides strong evidence of benefits. In this review, we summarize the types of stem cells, various delivery routes, and tracking tools for stem cell therapy of ischemic stroke. MSCs, EPCs, and NSCs are the most explored cell types for ischemic stroke treatment. Although the mechanisms of stem cell\u2010based therapies are not fully understood, the most possible functions of the transplanted cells are releasing growth factors and regulating microenvironment through paracrine mechanism. Clinical application of stem cell\u2010based therapy is still in its infancy. The next decade of stem cell research in stroke field needs to focus on combining different stem cells and different imaging modalities to fully explore the potential of this therapeutic avenue: from bench to bedside and vice versa.<\/jats:p>","DOI":"10.1111\/cns.12386","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T22:02:14Z","timestamp":1423778534000},"page":"337-347","source":"Crossref","is-referenced-by-count":76,"title":["Opportunities and Challenges: Stem Cell\u2010Based Therapy for the Treatment of Ischemic Stroke"],"prefix":"10.1111","volume":"21","author":[{"given":"Yao\u2010Hui","family":"Tang","sequence":"first","affiliation":[{"name":"Neuroscience and Neuroengineering Center Med\u2010X Research Institute and School of Biomedical Engineering Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010Yuan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurology Ruijin Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Neuroscience and Neuroengineering Center Med\u2010X Research Institute and School of Biomedical Engineering Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"Neuroscience and Neuroengineering Center Med\u2010X Research Institute and School of Biomedical Engineering Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u2010Yuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Neuroscience and Neuroengineering Center Med\u2010X Research Institute and School of Biomedical Engineering Shanghai Jiao Tong University Shanghai China"},{"name":"Department of Neurology Ruijin Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,10]]},"reference":[{"key":"e_1_2_23_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61953-4"},{"key":"e_1_2_23_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.494807"},{"key":"e_1_2_23_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.91"},{"key":"e_1_2_23_5_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X655145"},{"key":"e_1_2_23_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2013.11.007"},{"key":"e_1_2_23_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.11.055"},{"key":"e_1_2_23_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21572"},{"key":"e_1_2_23_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000063425.51108.8D"},{"key":"e_1_2_23_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1808"},{"key":"e_1_2_23_11_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.112.109017"},{"key":"e_1_2_23_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.8"},{"key":"e_1_2_23_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.06.062"},{"key":"e_1_2_23_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.11.010"},{"key":"e_1_2_23_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5457.1433"},{"key":"e_1_2_23_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0149-06.2006"},{"key":"e_1_2_23_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.55"},{"key":"e_1_2_23_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000154107"},{"key":"e_1_2_23_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm747"},{"key":"e_1_2_23_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp174"},{"key":"e_1_2_23_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr094"},{"key":"e_1_2_23_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.06.012"},{"key":"e_1_2_23_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05702.x"},{"key":"e_1_2_23_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000156"},{"key":"e_1_2_23_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005586"},{"key":"e_1_2_23_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/35040568"},{"key":"e_1_2_23_27_1","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1160\/TH03-06-0378","article-title":"Enhancement of neovascularization with cord blood cd133+ cell\u2010derived endothelial progenitor cell transplantation","volume":"91","author":"Yang C","year":"2004","journal-title":"Thromb Haemost"},{"key":"e_1_2_23_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.687038"},{"key":"e_1_2_23_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008443"},{"key":"e_1_2_23_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2014.05.012"},{"key":"e_1_2_23_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5302.964"},{"key":"e_1_2_23_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21919"},{"key":"e_1_2_23_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2009.03486.x"},{"key":"e_1_2_23_34_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-3496fje"},{"key":"e_1_2_23_35_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200420622"},{"key":"e_1_2_23_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1754"},{"key":"e_1_2_23_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005643"},{"key":"e_1_2_23_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073244"},{"key":"e_1_2_23_39_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0073"},{"key":"e_1_2_23_40_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0014"},{"key":"e_1_2_23_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl261"},{"key":"e_1_2_23_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001644"},{"key":"e_1_2_23_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-011-0806-5"},{"key":"e_1_2_23_44_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2009.0452"},{"key":"e_1_2_23_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.32"},{"key":"e_1_2_23_46_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2013.0182"},{"key":"e_1_2_23_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt278"},{"key":"e_1_2_23_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/scrt224"},{"key":"e_1_2_23_49_1","doi-asserted-by":"publisher","DOI":"10.1089\/biores.2014.0012"},{"key":"e_1_2_23_50_1","doi-asserted-by":"publisher","DOI":"10.1159\/000262318"},{"key":"e_1_2_23_51_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000084828.50310.6A"},{"key":"e_1_2_23_52_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2001.1367"},{"key":"e_1_2_23_53_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0226"},{"key":"e_1_2_23_54_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.086074"},{"key":"e_1_2_23_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2006.08.004"},{"key":"e_1_2_23_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2011.07.002"},{"key":"e_1_2_23_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.08.001"},{"key":"e_1_2_23_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.12.020"},{"key":"e_1_2_23_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2012.03.002"},{"key":"e_1_2_23_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.08.025"},{"key":"e_1_2_23_61_1","first-page":"3472","article-title":"Hydrogen peroxide preconditioning enhances the therapeutic efficacy of wharton's jelly mesenchymal stem cells after myocardial infarction","volume":"125","author":"Zhang J","year":"2012","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_23_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1571"},{"key":"e_1_2_23_63_1","article-title":"Bdnf pre\u2010treatment of human embryonic\u2010derived neural stem cells improves cell survival and functional recovery after transplantation in hypoxic\u2010ischemic stroke","author":"Rosenblum S","year":"2014","journal-title":"Cell Transplant"},{"key":"e_1_2_23_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1098"},{"key":"e_1_2_23_65_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2011.009"},{"key":"e_1_2_23_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.11.019"},{"key":"e_1_2_23_67_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X653002"},{"key":"e_1_2_23_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2012.11.003"},{"key":"e_1_2_23_69_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2011.0391"},{"key":"e_1_2_23_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.09.041"},{"key":"e_1_2_23_71_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2009.0158"},{"key":"e_1_2_23_72_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4BM00106K"},{"key":"e_1_2_23_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1878"},{"key":"e_1_2_23_74_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X657251"},{"key":"e_1_2_23_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.09.076"},{"key":"e_1_2_23_76_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.612788"},{"key":"e_1_2_23_77_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.10669"},{"key":"e_1_2_23_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mt.6300374"},{"key":"e_1_2_23_79_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034608"},{"key":"e_1_2_23_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.03.070"},{"key":"e_1_2_23_81_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408258102"},{"key":"e_1_2_23_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201202208"},{"key":"e_1_2_23_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1239"},{"key":"e_1_2_23_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20170"},{"key":"e_1_2_23_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2009.03.001"},{"key":"e_1_2_23_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.04684.x"},{"key":"e_1_2_23_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24695"},{"key":"e_1_2_23_88_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200308040"},{"key":"e_1_2_23_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.02.065"},{"key":"e_1_2_23_90_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-24-09733.2001"},{"key":"e_1_2_23_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12238"},{"key":"e_1_2_23_92_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108806"},{"key":"e_1_2_23_93_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087284"},{"key":"e_1_2_23_94_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-13396"},{"key":"e_1_2_23_95_1","doi-asserted-by":"crossref","first-page":"AWP107","DOI":"10.1161\/str.44.suppl_1.AWP107","article-title":"Optogenetic stimulation of human neural stem cell grafts in ischemic brain","volume":"44","author":"Daadi M","year":"2013","journal-title":"Stroke"},{"key":"e_1_2_23_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.06.017"},{"key":"e_1_2_23_97_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0037"},{"key":"e_1_2_23_98_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2451060731"},{"key":"e_1_2_23_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2011.03.006"},{"key":"e_1_2_23_100_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3nr00119a"},{"key":"e_1_2_23_101_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.732073"},{"key":"e_1_2_23_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-008-0182-z"},{"key":"e_1_2_23_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21280"},{"key":"e_1_2_23_104_1","first-page":"686","article-title":"Labeling stem cells with fluorescent dyes for non\u2010invasive detection with optical imaging","volume":"14","author":"Boddington S","year":"2008","journal-title":"J Vis Exp"},{"key":"e_1_2_23_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/bip.20139"},{"key":"e_1_2_23_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-002-1524-x"},{"key":"e_1_2_23_107_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0296-08.2008"},{"key":"e_1_2_23_108_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.107.043299"},{"key":"e_1_2_23_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2009.104"},{"key":"e_1_2_23_110_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.606368"},{"key":"e_1_2_23_111_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000062649.63838.C9"},{"key":"e_1_2_23_112_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/50\/19\/001"},{"key":"e_1_2_23_113_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-200311000-00005"},{"key":"e_1_2_23_114_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.108.058966"},{"key":"e_1_2_23_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.097"},{"key":"e_1_2_23_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-011-9369-9"},{"key":"e_1_2_23_117_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000163546.27639.AA"},{"key":"e_1_2_23_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.100"},{"key":"e_1_2_23_119_1","doi-asserted-by":"publisher","DOI":"10.2310\/7290.2008.0010"},{"key":"e_1_2_23_120_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.588954"},{"key":"e_1_2_23_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201402930"},{"key":"e_1_2_23_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70061-4"},{"key":"e_1_2_23_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2004.10.010"},{"key":"e_1_2_23_124_1","doi-asserted-by":"publisher","DOI":"10.1159\/000086518"},{"key":"e_1_2_23_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04960"},{"key":"e_1_2_23_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2007.05.028"},{"key":"e_1_2_23_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1024"},{"key":"e_1_2_23_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.11.040"},{"key":"e_1_2_23_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.03.030"},{"key":"e_1_2_23_130_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.677328"},{"key":"e_1_2_23_131_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093735"},{"key":"e_1_2_23_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.32"},{"key":"e_1_2_23_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.213"},{"key":"e_1_2_23_134_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2013.0338"},{"key":"e_1_2_23_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2009.02.001"},{"key":"e_1_2_23_136_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12275"},{"key":"e_1_2_23_137_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2011.566267"},{"key":"e_1_2_23_138_1","first-page":"419","article-title":"Nasal administration of stem cells: A promising novel route to treat neonatal ischemic brain damage","volume":"68","author":"Velthoven CT","year":"2010","journal-title":"Pediatr Res"},{"key":"e_1_2_23_139_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368914X684970"},{"key":"e_1_2_23_140_1","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2010.1130"},{"key":"e_1_2_23_141_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404474101"},{"key":"e_1_2_23_142_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.4.514"},{"key":"e_1_2_23_143_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.2.193"},{"key":"e_1_2_23_144_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2005.103.2.0304"},{"key":"e_1_2_23_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20246"},{"key":"e_1_2_23_146_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1104"},{"key":"e_1_2_23_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2011.09.008"},{"key":"e_1_2_23_148_1","doi-asserted-by":"publisher","DOI":"10.3727\/000000001783986972"},{"key":"e_1_2_23_149_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.61"},{"key":"e_1_2_23_150_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.11.030188.002231"},{"key":"e_1_2_23_151_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-195719"},{"key":"e_1_2_23_152_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000141680.49960.d7"},{"key":"e_1_2_23_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.04.033"},{"key":"e_1_2_23_154_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23063"},{"key":"e_1_2_23_155_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2011.0385"},{"key":"e_1_2_23_156_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2008-0333"},{"key":"e_1_2_23_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.10.017"},{"key":"e_1_2_23_158_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.454"},{"key":"e_1_2_23_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.724"},{"key":"e_1_2_23_160_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2011.07733.x"},{"key":"e_1_2_23_161_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368910X494885"},{"key":"e_1_2_23_162_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl207"},{"key":"e_1_2_23_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600527"},{"key":"e_1_2_23_164_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000290907.30814.42"},{"key":"e_1_2_23_165_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm306"},{"key":"e_1_2_23_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.12.009"},{"key":"e_1_2_23_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2013.02.005"},{"key":"e_1_2_23_168_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X657314"},{"key":"e_1_2_23_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2012.03.006"},{"key":"e_1_2_23_170_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2008-0075"},{"key":"e_1_2_23_171_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1908"},{"key":"e_1_2_23_172_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21745"},{"key":"e_1_2_23_173_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn198"},{"key":"e_1_2_23_174_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22667"},{"key":"e_1_2_23_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2012.10.015"},{"key":"e_1_2_23_176_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr063"},{"key":"e_1_2_23_177_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22458"},{"key":"e_1_2_23_178_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20501"},{"key":"e_1_2_23_179_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2005.103.1.0038"},{"key":"e_1_2_23_180_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.4.565"},{"key":"e_1_2_23_181_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-005-0229-y"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcns.12386","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.12386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T19:45:29Z","timestamp":1694547929000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cns.12386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,10]]},"references-count":180,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/cns.12386"],"URL":"https:\/\/doi.org\/10.1111\/cns.12386","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,10]]}}}