{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T06:02:45Z","timestamp":1783576965081,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T00:00:00Z","timestamp":1437696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Zonisamide is an orally administered antiepileptic drug that was first approved for clinical use in Japan in 1989. Since then, it has been licensed in Korea for a broad spectrum of epilepsies in adults and children, and in the<jats:styled-content style=\"fixed-case\">USA<\/jats:styled-content>for adjunctive therapy of adults with partial seizures, and in Europe for monotherapy of adults with newly diagnosed partial seizures and adjunctive therapy of adults and adolescents and children aged \u22656\u00a0years with partial seizures with or without secondary generalization. Zonisamide is a benzisoxazole derivative with a unique chemical structure, predictable dose\u2010dependent pharmacokinetics, and multiple complementary mechanisms of action. Treatment with zonisamide is well tolerated and is not known to be associated with clinically significant drug\u2013drug interactions, including with oral contraceptives or other antiepileptic drugs. There have been &gt;2\u00a0million patient\u2010years of experience with zonisamide for treatment of epilepsy, and this drug has International League Against Epilepsy level A evidence for efficacy\/effectiveness as initial monotherapy for adults with partial\u2010onset seizures. This review presents the evidence for zonisamide across the spectrum of epilepsy, with emphasis on real\u2010world clinical practice and special populations of patients (children, elderly patients, and women of childbearing age) who are likely to be treated in daily clinical practice.<\/jats:p>","DOI":"10.1111\/cns.12418","type":"journal-article","created":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T06:34:05Z","timestamp":1437719645000},"page":"683-691","source":"Crossref","is-referenced-by-count":39,"title":["Zonisamide: Review of Recent Clinical Evidence for Treatment of Epilepsy"],"prefix":"10.1111","volume":"21","author":[{"given":"Shang\u2010Yeong","family":"Kwan","sequence":"first","affiliation":[{"name":"Neurology Neurological Institute Taipei Veterans General Hospital Taipei Taiwan"},{"name":"School of Medicine National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao\u2010Chung","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Neurology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin\u2010Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"National Cheng Kung University Hospital Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ta\u2010Cheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Changhua Christian Hospital Changhua Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo\u2010Bin","family":"Jou","sequence":"additional","affiliation":[{"name":"Macky Memorial Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amitabh","family":"Dash","sequence":"additional","affiliation":[{"name":"Eisai Co. Ltd Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2011.622268"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12016"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656560903468728"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-013-0093-4"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/wnf.0b013e3180413d7d"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.4.4.493"},{"key":"e_1_2_10_8_1","unstructured":"Zonegran Prescribing Information. 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