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Discomfort and sensory changes caused by skin sunburn are the main common features experienced by many of us, a phenomena triggered by the combination of long and short wavelengths radiation (<jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>, respectively). Although the biological processes underlying <jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content> exposure are not fully understood, in the last few years many studies have made significant progress in characterizing sunburn at the cellular and molecular levels, making use of both humans and laboratory animal models. Here we review and reason that <jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content> can be used as an excellent model of sensitization and inflammation for pain research. <jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content>, particularly <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>, produces a controllable and sterile inflammation that causes a robust dose\u2010dependent hypersensitivity with minimal confounding effects. Importantly, we show that <jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content> animal models precisely recapitulate the sensory, cellular, and molecular changes observed in human skin, giving it great confidence as a translational model. Furthermore, in this article, we give an overview of the pharmacology underlying <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> inflammation, the latest advances in the field, and potential new targets for inflammatory pain.<\/jats:p>","DOI":"10.1111\/cns.12444","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T14:59:47Z","timestamp":1441205987000},"page":"118-126","source":"Crossref","is-referenced-by-count":59,"title":["Ultraviolet Radiation on the Skin: A Painful Experience?"],"prefix":"10.1111","volume":"22","author":[{"given":"Douglas M.","family":"Lopes","sequence":"first","affiliation":[{"name":"Neurorestoration group Wolfson Centre for Age\u2010Related Diseases King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"McMahon","sequence":"additional","affiliation":[{"name":"Neurorestoration group Wolfson Centre for Age\u2010Related Diseases King's College 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