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Although many causative gene mutations have been reported, the final common end stage is photoreceptor cell death. Unfortunately, no effective treatments or therapeutic agents have been discovered. Heat shock protein 70 (<jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>70) is highly conserved and has antiapoptotic activities. A few reports have shown that <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>70 plays a role in <jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>s. Thus, we focused on the role of <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>70 in photoreceptor cell death. Using the <jats:italic>N<\/jats:italic>\u2010methyl\u2010<jats:italic>N<\/jats:italic>\u2010nitrosourea (<jats:styled-content style=\"fixed-case\">MNU<\/jats:styled-content>)\u2010induced photoreceptor cell death model in mice, we could examine two stages of the novel cell death mechanism; the early stage, including <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>70 cleavage through protein carbonylation by production of reactive oxygen species, lipid peroxidation and Ca<jats:sup>2+<\/jats:sup> influx\/calpain activation, and the late stage of cathepsin and\/or caspase activation. The upregulation of intact <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>70 expression by its inducer is likely to protect photoreceptor cells. In this review, we focus on the role of <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>70 and the novel cell death signaling process in <jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>s. We also describe candidate therapeutic agents for <jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>s.<\/jats:p>","DOI":"10.1111\/cns.12471","type":"journal-article","created":{"date-parts":[[2015,10,28]],"date-time":"2015-10-28T11:35:48Z","timestamp":1446032148000},"page":"7-14","source":"Crossref","is-referenced-by-count":29,"title":["A role of Heat Shock Protein 70 in Photoreceptor Cell Death: Potential as a Novel Therapeutic Target in Retinal Degeneration"],"prefix":"10.1111","volume":"22","author":[{"given":"Ayako","family":"Furukawa","sequence":"first","affiliation":[{"name":"Graduate School and Faculty of Pharmaceutical Sciences Suzuka University of Medical Science Suzuka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Koriyama","sequence":"additional","affiliation":[{"name":"Graduate School and Faculty of Pharmaceutical Sciences Suzuka University of Medical Science Suzuka 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