{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:46:02Z","timestamp":1765485962233},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,18]],"date-time":"2016-01-18T00:00:00Z","timestamp":1453075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Presence of white matter hyperintensity (<jats:styled-content style=\"fixed-case\">WMH<\/jats:styled-content>) on <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> is a marker of cerebral small vessel disease and is associated with increased small vessel stroke and increased risk of hemorrhagic transformation (<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>) after thrombolysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We sought to determine whether white matter hypoperfusion (<jats:styled-content style=\"fixed-case\">WMHP<\/jats:styled-content>) on perfusion <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CTP<\/jats:styled-content>) was related to <jats:styled-content style=\"fixed-case\">WMH<\/jats:styled-content>, and if <jats:styled-content style=\"fixed-case\">WMHP<\/jats:styled-content> predisposed to acute lacunar stroke subtype and <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> after thrombolysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Acute ischemic stroke patients within 12 h of symptom onset at 2 centers were prospectively recruited between 2011 and 2013 for the International Stroke Perfusion Imaging Registry. Participants routinely underwent baseline <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> imaging, including <jats:styled-content style=\"fixed-case\">CTP<\/jats:styled-content>, and follow\u2010up imaging with <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> at 24 h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 229 ischemic stroke patients, 108 were Caucasians and 121 Chinese. In the contralateral white matter, patients with acute lacunar stroke had lower cerebral blood flow (<jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content>) and cerebral blood volume (<jats:styled-content style=\"fixed-case\">CBV<\/jats:styled-content>), compared to those with other stroke subtypes (<jats:italic>P<\/jats:italic> = 0.041). There were 46 patients with <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">WMHP<\/jats:styled-content> was associated with increased risk of <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.417, <jats:italic>P<\/jats:italic> = 0.002). Compared to previously reported predictors of <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> WMHP<\/jats:styled-content> performed better than infarct core volume (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.341, <jats:italic>P<\/jats:italic> = 0.034), very low <jats:styled-content style=\"fixed-case\">CBV<\/jats:styled-content> volume (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.249, <jats:italic>P<\/jats:italic> = 0.026), and severely delayed perfusion (Tmax&gt;14 second <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.372, <jats:italic>P<\/jats:italic> = 0.011). Patients with <jats:styled-content style=\"fixed-case\">WMHP<\/jats:styled-content> also had larger acute infarcts and increased infarct growth compared to those without <jats:styled-content style=\"fixed-case\">WMHP<\/jats:styled-content> (mean 28 mL vs. 13 mL <jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>White matter hypoperfusion remote to the acutely ischemic region on <jats:styled-content style=\"fixed-case\">CTP<\/jats:styled-content> is a marker of small vessel disease and was associated with increased <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>, larger acute infarct cores, and greater infarct growth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.12491","type":"journal-article","created":{"date-parts":[[2016,1,18]],"date-time":"2016-01-18T07:49:30Z","timestamp":1453103370000},"page":"238-243","source":"Crossref","is-referenced-by-count":18,"title":["Global White Matter Hypoperfusion on 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