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We also examined the effect of prolonged fasudil treatment on arterial reactivity and hemorrhagic transformation. Adult Sprague Dawley rats were treated by streptozotocin to induce type 1 diabetes. These hyperglycemic rats received fasudil pretreatment and then underwent transient middle cerebral artery occlusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that diabetes caused arteries narrowing in the circus Willis as early as 2\u00a0weeks after streptozotocin injection (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). These vessels were further constricted after middle cerebral artery occlusion. L\u2010<jats:styled-content style=\"fixed-case\">NAME<\/jats:styled-content> could induce regional constrictions and impaired relaxation in hyperglycemic animals. Furthermore, hemorrhagic transformation was also increased in the hyperglycemic rats compared to the control (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). In fasudil\u2010treated rats, the internal carotid artery narrowing was ameliorated and L\u2010<jats:styled-content style=\"fixed-case\">NAME<\/jats:styled-content>\u2010induced regional constriction was abolished. Importantly, stroke prognosis was improved in fasudil\u2010treated rats compared to the control (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our dynamic angiographic data demonstrated that diabetes could impair the cerebral arterial reactivity. Prolonged fasudil treatment could attenuate arterial dysfunction and improve the prognosis of ischemic stroke by affecting both the large and small vasculature.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.12500","type":"journal-article","created":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T10:36:53Z","timestamp":1454582213000},"page":"316-324","source":"Crossref","is-referenced-by-count":17,"title":["Vessel Dilation Attenuates Endothelial Dysfunction Following Middle Cerebral Artery Occlusion in Hyperglycemic Rats"],"prefix":"10.1111","volume":"22","author":[{"given":"Zhi\u2010Hao","family":"Mu","sequence":"first","affiliation":[{"name":"Department of Neurology Ruijin Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurology Ruijin Hospital School of Medicine Shanghai Jiao Tong University Shanghai 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