{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T22:15:41Z","timestamp":1774476941401,"version":"3.50.1"},"reference-count":111,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T00:00:00Z","timestamp":1459123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373414"],"award-info":[{"award-number":["81373414"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81130061"],"award-info":[{"award-number":["81130061"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Adult neurogenesis is the process of generating new neurons throughout life in the olfactory bulb and hippocampus of most mammalian species, which is closely related to aging and disease. Nicotinamide phosphoribosyltransferase (<jats:styled-content style=\"fixed-case\">NAMPT<\/jats:styled-content>), also an adipokine known as visfatin, is the rate\u2010limiting enzyme for mammalian nicotinamide adenine dinucleotide (<jats:styled-content style=\"fixed-case\">NAD<\/jats:styled-content>) salvage synthesis by generating nicotinamide mononucleotide (<jats:styled-content style=\"fixed-case\">NMN<\/jats:styled-content>) from nicotinamide. Recent findings from our laboratory and other laboratories have provided much evidence that <jats:styled-content style=\"fixed-case\">NAMPT<\/jats:styled-content> might serve as a therapeutic target to restore adult neurogenesis. <jats:styled-content style=\"fixed-case\">NAMPT<\/jats:styled-content>\u2010mediated <jats:styled-content style=\"fixed-case\">NAD<\/jats:styled-content> biosynthesis in neural stem\/progenitor cells is important for their proliferation, self\u2010renewal, and formation of oligodendrocytes <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic>. Therapeutic interventions by the administration of <jats:styled-content style=\"fixed-case\">NMN<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> NAD<\/jats:styled-content>, or recombinant <jats:styled-content style=\"fixed-case\">NAMPT<\/jats:styled-content> are effective for restoring adult neurogenesis in several neurological diseases. We summarize adult neurogenesis in aging, ischemic stroke, traumatic brain injury, and neurodegenerative disease and review the advances of targeting <jats:styled-content style=\"fixed-case\">NAMPT<\/jats:styled-content> in restoring neurogenesis. Specifically, we provide emphasis on the P7C3 family, a class of proneurogenic compounds that are potential <jats:styled-content style=\"fixed-case\">NAMPT<\/jats:styled-content> activators, which might shed light on future drug development in neurogenesis restoration.<\/jats:p>","DOI":"10.1111\/cns.12539","type":"journal-article","created":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T08:53:46Z","timestamp":1459155226000},"page":"431-439","source":"Crossref","is-referenced-by-count":33,"title":["Targeting Nicotinamide Phosphoribosyltransferase as a Potential Therapeutic Strategy to Restore Adult Neurogenesis"],"prefix":"10.1111","volume":"22","author":[{"given":"Shu\u2010Na","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pharmacology Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian\u2010Ying","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cell Biology Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao\u2010Yu","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Second Military Medical University Shanghai China"},{"name":"Center of Stroke Beijing Institute for Brain Disorders Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901240303"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/3305"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2014.07.003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(04)00111-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.01.033"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.002"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.03.030"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a018994"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.03.002"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1474-9728.2003.00046.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2010.03.017"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10411"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0314-8"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.081011098"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603512103"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.09.074"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/08977150260139084"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4886(03)00241-3"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4547(20010215)63:4<313::AID-JNR1025>3.0.CO;2-4"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12410"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12344"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12264"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.04.017"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1532244100"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1138711"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12317"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1265"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803955106"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0798-755"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/35081564"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2723-12.2012"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.04.028"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.01.044"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12386"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12392"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2014.9"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12295"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64875-6"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.1990.9.579"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.14.2.1431"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.4.1168-1174.2001"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200211)32:11<3225::AID-IMMU3225>3.0.CO;2-L"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171641"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1170803"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12273"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.119"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.009216"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(03)00476-9"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.09.003"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.07.035"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.136739"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2015.117"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2014.04.002"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M408388200"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040195"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.11.034"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007897"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2009.11.002"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1906"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M506162200"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M401138200"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0040031"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.183509.111"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt122"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2012.10.002"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2015.08.012"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/embj.201386917"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.71"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22236"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.04.002"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn288"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01404.x"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.08.014"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.07.002"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.11.037"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.06.016"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.027"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-21631-2_7"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e31820eb8f6"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5552-09.2010"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07566.x"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.509158"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-014-0486-1"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2014.12.004"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10989-014-9449-1"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2012.01.007"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.8.1.18274"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000332"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12388"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90780.2008"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu220"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep10043"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep12657"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2015.02.004"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.07.040"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.06.018"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm401919s"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja108211m"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.08.066"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405310101"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506713102"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1213956109"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2015.016"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2013.3135"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.08.030"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.10.005"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2015.02.008"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2014.34"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1213960109"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.11.019"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12517"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcns.12539","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.12539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T00:50:12Z","timestamp":1695516612000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cns.12539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,28]]},"references-count":111,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/cns.12539"],"URL":"https:\/\/doi.org\/10.1111\/cns.12539","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,28]]}}}